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Large Language Model-based Vision-Language Models (LLM-based VLMs) have demonstrated impressive results in various vision-language understanding tasks. However, how well these VLMs can see image detail beyond the semantic level remains…

Computer Vision and Pattern Recognition · Computer Science 2024-08-08 Chenhui Gou , Abdulwahab Felemban , Faizan Farooq Khan , Deyao Zhu , Jianfei Cai , Hamid Rezatofighi , Mohamed Elhoseiny

Vision-language models (VLMs), such as CLIP and ALIGN, are generally trained on datasets consisting of image-caption pairs obtained from the web. However, real-world multimodal datasets, such as healthcare data, are significantly more…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Maya Varma , Jean-Benoit Delbrouck , Sarah Hooper , Akshay Chaudhari , Curtis Langlotz

Deep learning methods, in particular convolutional neural networks, have emerged as a powerful tool in medical image computing tasks. While these complex models provide excellent performance, their black-box nature may hinder real-world…

Image and Video Processing · Electrical Eng. & Systems 2022-10-18 Yuzhe Lu , Adam Perer

This paper proposes Comprehensive Pathology Language Image Pre-training (CPLIP), a new unsupervised technique designed to enhance the alignment of images and text in histopathology for tasks such as classification and segmentation. This…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Sajid Javed , Arif Mahmood , Iyyakutti Iyappan Ganapathi , Fayaz Ali Dharejo , Naoufel Werghi , Mohammed Bennamoun

The application of deep learning models in medical diagnosis has showcased considerable efficacy in recent years. Nevertheless, a notable limitation involves the inherent lack of explainability during decision-making processes. This study…

Image and Video Processing · Electrical Eng. & Systems 2024-05-01 Konstantinos Pasvantis , Eftychios Protopapadakis

Vision-language models (VLMs) have recently shown remarkable zero-shot performance in medical image understanding, yet their grounding ability, the extent to which textual concepts align with visual evidence, remains underexplored. In the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Haozhe Luo , Shelley Zixin Shu , Ziyu Zhou , Sebastian Otalora , Mauricio Reyes

Vision language models (VLMs) achieve strong performance on RGB imagery, but they do not generalize to thermal images. Thermal sensing plays a critical role in settings where visible light fails, including nighttime surveillance, search and…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Ayush Shrivastava , Kirtan Gangani , Laksh Jain , Mayank Goel , Nipun Batra

Recent advances in vision-language models (VLMs) have shown remarkable potential in bridging visual and textual modalities. In computational pathology, domain-specific VLMs, which are pre-trained on extensive histopathology image-text…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Anh Tien Nguyen , Keunho Byeon , Kyungeun Kim , Jin Tae Kwak

Leukemia epitomizes the class of highly complex diseases that new technologies aim to tackle by using large sets of single-cell level information. Achieving such goal depends critically not only on experimental techniques but also on…

Quantitative Methods · Quantitative Biology 2014-06-02 Jose M. G. Vilar

Artificial intelligence (AI) is reshaping computational and network biology by enabling new approaches to decode cellular communication networks. We introduce Hierarchical Molecular Language Models (HMLMs), a novel framework that models…

Molecular Networks · Quantitative Biology 2025-12-16 Hasi Hays , Yue Yu , William J. Richardson

Mainstream vision-language models (VLMs) fundamentally struggle with severe optical ambiguities, such as reflections and transparent objects, due to the inherent limitations of standard RGB inputs. While polarization imaging captures…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Yuliang Li , Chu Zhou , Heng Guo , Boxin Shi , Imari Sato , Zhanyu Ma

While recent vision-and-language models (VLMs) like CLIP are a powerful tool for analyzing text and images in a shared semantic space, they do not explicitly model the hierarchical nature of the set of texts which may describe an image.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Morris Alper , Hadar Averbuch-Elor

Vision-language models are integral to computer vision research, yet many high-performing models remain closed-source, obscuring their data, design and training recipe. The research community has responded by using distillation from…

Human expertise in chemistry and biomedicine relies on contextual molecular understanding, a capability that large language models (LLMs) can extend through fine-grained alignment between molecular structures and text. Recent multimodal…

Computation and Language · Computer Science 2025-03-10 Sumin Ha , Jun Hyeong Kim , Yinhua Piao , Sun Kim

Examining blood microscopic images for leukemia is necessary when expensive equipment for flow cytometry is unavailable. Automated systems can ease the burden on medical experts for performing this examination and may be especially helpful…

Computer Vision and Pattern Recognition · Computer Science 2020-04-02 Jonas Prellberg , Oliver Kramer

Acute lymphoblastic leukemia (ALL) is a prevalent hematological malignancy in both pediatric and adult populations. Early and accurate detection with precise subtyping is essential for guiding therapy. Conventional workflows are complex,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Md. Maruf , Md. Mahbubul Haque , Bishowjit Paul

We introduce Concept Bottleneck Protein Language Models (CB-pLM), a generative masked language model with a layer where each neuron corresponds to an interpretable concept. Our architecture offers three key benefits: i) Control: We can…

Digital mammography is essential to breast cancer detection, and deep learning offers promising tools for faster and more accurate mammogram analysis. In radiology and other high-stakes environments, uninterpretable ("black box") deep…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Julia Yang , Alina Jade Barnett , Jon Donnelly , Satvik Kishore , Jerry Fang , Fides Regina Schwartz , Chaofan Chen , Joseph Y. Lo , Cynthia Rudin

The proliferation of Vision-Language Models (VLMs) in the past several years calls for rigorous and comprehensive evaluation methods and benchmarks. This work analyzes existing VLM evaluation techniques, including automated metrics,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Alexis Roger , Prateek Humane , Daniel Z. Kaplan , Kshitij Gupta , Qi Sun , George Adamopoulos , Jonathan Siu Chi Lim , Quentin Anthony , Edwin Fennell , Irina Rish

Multi-modal Large Language Models (MLLMs) have demonstrated remarkable capabilities in understanding and generating content across various modalities, such as images and text. However, their interpretability remains a challenge, hindering…

Computer Vision and Pattern Recognition · Computer Science 2024-05-29 Loris Giulivi , Giacomo Boracchi
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