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Motivation: Drug discovery demands rapid quantification of compound-protein interaction (CPI). However, there is a lack of methods that can predict compound-protein affinity from sequences alone with high applicability, accuracy, and…

Biomolecules · Quantitative Biology 2020-12-17 Mostafa Karimi , Di Wu , Zhangyang Wang , Yang Shen

The Tsetlin Machine (TM) is a propositional logic based model that uses conjunctive clauses to learn patterns from data. As with typical neural networks, the performance of a Tsetlin Machine is largely dependent on its parameter count, with…

Artificial Intelligence · Computer Science 2025-04-03 Calvin Kinateder

Despite that current reading comprehension systems have achieved significant advancements, their promising performances are often obtained at the cost of making an ensemble of numerous models. Besides, existing approaches are also…

Computation and Language · Computer Science 2018-09-18 Minghao Hu , Yuxing Peng , Furu Wei , Zhen Huang , Dongsheng Li , Nan Yang , Ming Zhou

Knowledge distillation aims to compress a powerful yet cumbersome teacher model into a lightweight student model without much sacrifice of performance. For this purpose, various approaches have been proposed over the past few years,…

Computer Vision and Pattern Recognition · Computer Science 2022-03-29 Defang Chen , Jian-Ping Mei , Hailin Zhang , Can Wang , Yan Feng , Chun Chen

Neural machine translation (NMT) offers a novel alternative formulation of translation that is potentially simpler than statistical approaches. However to reach competitive performance, NMT models need to be exceedingly large. In this paper…

Computation and Language · Computer Science 2016-09-23 Yoon Kim , Alexander M. Rush

Sequential recommendation models user interests based on historical behaviors to provide personalized recommendation. Previous sequential recommendation algorithms primarily employ neural networks to extract features of user interests,…

Information Retrieval · Computer Science 2024-09-24 Li Li , Mingyue Cheng , Zhiding Liu , Hao Zhang , Qi Liu , Enhong Chen

Determination of binding affinity of proteins in the formation of protein complexes requires sophisticated, expensive and time-consuming experimentation which can be replaced with computational methods. Most computational prediction…

Quantitative Methods · Quantitative Biology 2020-12-14 Wajid Arshad Abbasi , Fahad Ul Hassan , Adiba Yaseen , Fayyaz Ul Amir Afsar Minhas

Knowledge distillation is a critical technique to transfer knowledge between models, typically from a large model (the teacher) to a more fine-grained one (the student). The objective function of knowledge distillation is typically the…

Computation and Language · Computer Science 2021-06-03 Xinyu Wang , Yong Jiang , Zhaohui Yan , Zixia Jia , Nguyen Bach , Tao Wang , Zhongqiang Huang , Fei Huang , Kewei Tu

The concept of compressing deep Convolutional Neural Networks (CNNs) is essential to use limited computation, power, and memory resources on embedded devices. However, existing methods achieve this objective at the cost of a drop in…

Computer Vision and Pattern Recognition · Computer Science 2021-04-20 Waqar Ahmed , Andrea Zunino , Pietro Morerio , Vittorio Murino

Current state-of-the-art object detectors are at the expense of high computational costs and are hard to deploy to low-end devices. Knowledge distillation, which aims at training a smaller student network by transferring knowledge from a…

Computer Vision and Pattern Recognition · Computer Science 2020-06-24 Ruoyu Sun , Fuhui Tang , Xiaopeng Zhang , Hongkai Xiong , Qi Tian

Many natural language processing tasks can be modeled into structured prediction and solved as a search problem. In this paper, we distill an ensemble of multiple models trained with different initialization into a single model. In addition…

Computation and Language · Computer Science 2018-05-30 Yijia Liu , Wanxiang Che , Huaipeng Zhao , Bing Qin , Ting Liu

Deep neural network architectures have attained remarkable improvements in scene understanding tasks. Utilizing an efficient model is one of the most important constraints for limited-resource devices. Recently, several compression methods…

Computer Vision and Pattern Recognition · Computer Science 2020-10-12 Mahdi Ghorbani , Fahimeh Fooladgar , Shohreh Kasaei

Techniques such as ensembling and distillation promise model quality improvements when paired with almost any base model. However, due to increased test-time cost (for ensembles) and increased complexity of the training pipeline (for…

Machine Learning · Computer Science 2020-08-24 Rohan Anil , Gabriel Pereyra , Alexandre Passos , Robert Ormandi , George E. Dahl , Geoffrey E. Hinton

Deep Neural Networks have achieved huge success at a wide spectrum of applications from language modeling, computer vision to speech recognition. However, nowadays, good performance alone is not sufficient to satisfy the needs of practical…

Machine Learning · Computer Science 2018-12-31 Xuan Liu , Xiaoguang Wang , Stan Matwin

Knowledge distillation is classically a procedure where a neural network is trained on the output of another network along with the original targets in order to transfer knowledge between the architectures. The special case of…

Machine Learning · Computer Science 2021-10-18 Kenneth Borup , Lars N. Andersen

Knowledge distillation conducts an effective model compression method while holding some limitations:(1) the feature based distillation methods only focus on distilling the feature map but are lack of transferring the relation of data…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 Muzhou Yu , Sia Huat Tan , Kailu Wu , Runpei Dong , Linfeng Zhang , Kaisheng Ma

Knowledge distillation has become one of the most important model compression techniques by distilling knowledge from larger teacher networks to smaller student ones. Although great success has been achieved by prior distillation methods…

Machine Learning · Computer Science 2021-08-31 Yuzhang Shang , Bin Duan , Ziliang Zong , Liqiang Nie , Yan Yan

Top-performing machine learning systems, such as deep neural networks, large ensembles and complex probabilistic graphical models, can be expensive to store, slow to evaluate and hard to integrate into larger systems. Ideally, we would like…

Machine Learning · Statistics 2015-10-09 George Papamakarios

Predicting the binding affinity of protein protein complexes directly from sequence remains a challenging problem, particularly in the absence of reliable structural information. Here I present ProtT Affinity, a sequence only model that…

Quantitative Methods · Quantitative Biology 2025-11-21 Hongfu Lou

Feature-based knowledge distillation has been applied to compress modern recommendation models, usually with projectors that align student (small) recommendation models' dimensions with teacher dimensions. However, existing studies have…

Information Retrieval · Computer Science 2025-01-14 Zhangchi Zhu , Wei Zhang