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Recent work has considered whether large language models (LLMs) can function as planners: given a task, generate a plan. We investigate whether LLMs can serve as generalized planners: given a domain and training tasks, generate a program…

Artificial Intelligence · Computer Science 2023-12-20 Tom Silver , Soham Dan , Kavitha Srinivas , Joshua B. Tenenbaum , Leslie Pack Kaelbling , Michael Katz

Planning in code is considered a more reliable approach for many orchestration tasks. This is because code is more tractable than steps generated via Natural Language and make it easy to support more complex sequences by abstracting…

Software Engineering · Computer Science 2024-08-19 Nastaran Bassamzadeh , Chhaya Methani

Importance: We introduce a novel Retrieval Augmented Generation (RAG)-Large Language Model (LLM) framework as a Clinical Decision Support Systems (CDSS) to support safe medication prescription. Objective: To evaluate the efficacy of…

Accurate and safe medication recommendations are critical for effective clinical decision-making, especially in multimorbidity cases. However, existing systems rely on point-wise prediction paradigms that overlook synergistic drug effects…

Machine Learning · Computer Science 2026-05-19 Chenxiao Fan , Chongming Gao , Wentao Shi , Yaxin Gong , Zihao Zhao , Fuli Feng

Recent advances in Large Language Models have led to remarkable achievements across a variety of Natural Language Processing tasks, making prompt engineering increasingly central to guiding model outputs. While manual methods can be…

Computation and Language · Computer Science 2025-07-15 Wendi Cui , Zhuohang Li , Hao Sun , Damien Lopez , Kamalika Das , Bradley A. Malin , Sricharan Kumar , Jiaxin Zhang

Finetuning a Large Language Model (LLM) is crucial for generating results towards specific objectives. This research delves into the realm of drug optimization and introduce a novel reinforcement learning algorithm to finetune a drug…

Machine Learning · Computer Science 2025-02-12 Xuefeng Liu , Songhao Jiang , Siyu Chen , Zhuoran Yang , Yuxin Chen , Ian Foster , Rick Stevens

Intrigued by the claims of emergent reasoning capabilities in LLMs trained on general web corpora, in this paper, we set out to investigate their planning capabilities. We aim to evaluate (1) how good LLMs are by themselves in generating…

Artificial Intelligence · Computer Science 2023-02-15 Karthik Valmeekam , Sarath Sreedharan , Matthew Marquez , Alberto Olmo , Subbarao Kambhampati

Mathematical optimization is fundamental to decision-making across diverse domains, from operations research to healthcare. Yet, translating real-world problems into optimization models remains a difficult task, often demanding specialized…

Machine Learning · Computer Science 2025-06-06 Nicolás Astorga , Tennison Liu , Yuanzhang Xiao , Mihaela van der Schaar

Large Language Models (LLMs) excel at general-purpose reasoning by leveraging broad commonsense knowledge, but they remain limited in tasks requiring personalized reasoning over multifactorial personal data. This limitation constrains their…

Computation and Language · Computer Science 2025-09-03 Zhongqi Yang , Amir Rahmani

Although heuristic search is one of the most successful approaches to classical planning, this planning paradigm does not apply straightforwardly to Generalized Planning (GP). This paper adapts the planning as heuristic search paradigm to…

Artificial Intelligence · Computer Science 2022-05-13 Javier Segovia-Aguas , Sergio Jiménez , Anders Jonsson

AI-generated content technologies are widely used in content creation. However, current AIGC systems rely heavily on creators' inspiration, rarely generating truly user-personalized content. In real-world applications such as online…

Information Retrieval · Computer Science 2025-08-26 Junyi Chen , Lu Chi , Siliang Xu , Shiwei Ran , Bingyue Peng , Zehuan Yuan

Automated planning is concerned with developing efficient algorithms to generate plans or sequences of actions to achieve a specific goal in a given environment. Emerging Large Language Models (LLMs) can answer questions, write high-quality…

The integration of Large Language Models (LLMs) into medical applications has sparked widespread interest across the healthcare industry, from drug discovery and development to clinical decision support, assisting telemedicine, medical…

Computation and Language · Computer Science 2024-12-03 Zifeng Wang , Hanyin Wang , Benjamin Danek , Ying Li , Christina Mack , Hoifung Poon , Yajuan Wang , Pranav Rajpurkar , Jimeng Sun

Large language models (LLMs) have revolutionized Natural Language Processing (NLP) by minimizing the need for complex feature engineering. However, the application of LLMs in specialized domains like biopharmaceuticals and chemistry remains…

In modern commercial systems, including Recommendation, Ranking, and E-Commerce platforms, there is a trend towards improving customer experiences by incorporating Personalization context as input into Large Language Models (LLMs). However,…

Computation and Language · Computer Science 2024-09-23 Jiarui Zhang

Policy design for various systems controllers has conventionally been a manual process, with domain experts carefully tailoring heuristics for the specific instance in which the policy will be deployed. In this paper, we re-imagine policy…

Operating Systems · Computer Science 2025-10-13 Rohit Dwivedula , Divyanshu Saxena , Aditya Akella , Swarat Chaudhuri , Daehyeok Kim

Automatic performance tuning (auto-tuning) is essential for optimizing high-performance applications, where vast and irregular search spaces make manual exploration infeasible. While auto-tuners traditionally rely on classical approaches…

Machine Learning · Computer Science 2026-04-01 Floris-Jan Willemsen , Niki van Stein , Ben van Werkhoven

The generation of planning domains from natural language descriptions remains an open problem even with the advent of large language models and reasoning models. Recent work suggests that while LLMs have the ability to assist with domain…

Artificial Intelligence · Computer Science 2026-04-23 James Oswald , Daniel Obolensky , Volodymyr Varha , Vasilije Dragovic , Kavitha Srinivas , Harsha Kokel , Michael Katz , Shirin Sohrabi

Large Language Models (LLMs) employ three popular training approaches: Masked Language Models (MLM), Causal Language Models (CLM), and Sequence-to-Sequence Models (seq2seq). However, each approach has its strengths and limitations, and…

Machine Learning · Computer Science 2025-02-18 Xuefeng Liu , Songhao Jiang , Bo Li , Rick Stevens

The advancement of artificial intelligence algorithms has expanded their application to several fields such as the biomedical domain. Artificial intelligence systems, including Large Language Models (LLMs), can be particularly advantageous…