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Effective clinical history taking is a foundational yet underexplored component of clinical reasoning. While large language models (LLMs) have shown promise on static benchmarks, they often fall short in dynamic, multi-turn diagnostic…

Computation and Language · Computer Science 2026-01-30 Yang Zhou , Zhenting Sheng , Mingrui Tan , Yuting Song , Jun Zhou , Yu Heng Kwan , Lian Leng Low , Yang Bai , Yong Liu

We introduce Directional Stimulus Prompting, a novel framework for guiding black-box large language models (LLMs) toward specific desired outputs. Instead of directly adjusting LLMs, our method employs a small tunable policy model (e.g.,…

Computation and Language · Computer Science 2023-10-11 Zekun Li , Baolin Peng , Pengcheng He , Michel Galley , Jianfeng Gao , Xifeng Yan

Background: More than 80% of U.S. cancer care is delivered in community settings, where survival remains worse than at academic centers. Clinicians must integrate genomics, staging, radiology, pathology, and changing guidelines, creating…

Computational pathology foundation models (CPathFMs) have emerged as a powerful approach for analyzing histopathological data, leveraging self-supervised learning to extract robust feature representations from unlabeled whole-slide images.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Ajit J. Nirmal , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Recommender systems are pivotal in enhancing user experiences across various web applications by analyzing the complicated relationships between users and items. Knowledge graphs(KGs) have been widely used to enhance the performance of…

Information Retrieval · Computer Science 2024-07-02 Guangsi Shi , Xiaofeng Deng , Linhao Luo , Lijuan Xia , Lei Bao , Bei Ye , Fei Du , Shirui Pan , Yuxiao Li

The selection of appropriate medical imaging procedures is a critical and complex clinical decision, guided by extensive evidence-based standards such as the ACR Appropriateness Criteria (ACR-AC). However, the underutilization of these…

Quantitative Methods · Quantitative Biology 2025-10-07 Satrio Pambudi , Filippo Menolascina

In Natural Language Processing (NLP), Machine Reading Comprehension (MRC) is the task of answering a question based on a given context. To handle questions in the medical domain, modern language models such as BioBERT, SciBERT and even…

Computation and Language · Computer Science 2024-12-16 Saptarshi Sengupta , Connor Heaton , Suhan Cui , Soumalya Sarkar , Prasenjit Mitra

Despite strong performance in medical question-answering, the clinical adoption of Large Language Models (LLMs) is critically hampered by their opaque 'black-box' reasoning, limiting clinician trust. This challenge is compounded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Chao Ding , Mouxiao Bian , Pengcheng Chen , Hongliang Zhang , Tianbin Li , Lihao Liu , Jiayuan Chen , Zhuoran Li , Yabei Zhong , Yongqi Liu , Haiqing Huang , Dongming Shan , Junjun He , Jie Xu

Automatic medical report generation (MRG) is of great research value as it has the potential to relieve radiologists from the heavy burden of report writing. Despite recent advancements, accurate MRG remains challenging due to the need for…

Computer Vision and Pattern Recognition · Computer Science 2024-01-15 Haibo Jin , Haoxuan Che , Yi Lin , Hao Chen

The integration of Artificial Intelligence (AI), especially Large Language Models (LLMs), into the clinical diagnosis process offers significant potential to improve the efficiency and accessibility of medical care. While LLMs have shown…

Computation and Language · Computer Science 2024-10-15 Mingyu Derek Ma , Chenchen Ye , Yu Yan , Xiaoxuan Wang , Peipei Ping , Timothy S Chang , Wei Wang

Large Language Model (LLM) assistants, such as ChatGPT, have emerged as potential alternatives to search methods for helping users navigate complex, feature-rich software. LLMs use vast training data from domain-specific texts, software…

Human-Computer Interaction · Computer Science 2024-02-14 Anjali Khurana , Hari Subramonyam , Parmit K Chilana

The growing interest in Large Language Models (LLMs) for specialized applications has revealed a significant challenge: when tailored to specific domains, LLMs tend to experience catastrophic forgetting, compromising their general…

Computation and Language · Computer Science 2024-03-06 Rui Wang , Fei Mi , Yi Chen , Boyang Xue , Hongru Wang , Qi Zhu , Kam-Fai Wong , Ruifeng Xu

Large language models (LLMs) have recently showcased remarkable capabilities, spanning a wide range of tasks and applications, including those in the medical domain. Models like GPT-4 excel in medical question answering but may face…

Computation and Language · Computer Science 2025-07-02 Bowen Wang , Jiuyang Chang , Yiming Qian , Guoxin Chen , Junhao Chen , Zhouqiang Jiang , Jiahao Zhang , Yuta Nakashima , Hajime Nagahara

Recommender systems are essential for guiding users through the vast and diverse landscape of digital content by delivering personalized and relevant suggestions. However, improving both personalization and interpretability remains a…

Information Retrieval · Computer Science 2025-08-05 Danial Ebrat , Tina Aminian , Sepideh Ahmadian , Luis Rueda

Machine learning (ML) has the potential to revolutionize various domains, but its adoption is often hindered by the disconnect between the needs of domain experts and translating these needs into robust and valid ML tools. Despite recent…

Machine Learning · Computer Science 2025-12-22 Evgeny Saveliev , Jiashuo Liu , Nabeel Seedat , Anders Boyd , Mihaela van der Schaar

Large language models (LLMs) have revolutionized Natural Language Processing (NLP) by minimizing the need for complex feature engineering. However, the application of LLMs in specialized domains like biopharmaceuticals and chemistry remains…

Objective. Clinical AI documentation systems require evaluation methodologies that are clinically valid, economically viable, and sensitive to iterative changes. Methods requiring expert review per scoring instance are too slow and…

Artificial Intelligence · Computer Science 2026-04-28 Aaryan Shah , Andrew Hines , Alexia Downs , Denis Bajet , Paulius Mui , Fabiano Araujo , Laura Offutt , Aida Rutledge , Elizabeth Jimenez

Designing optimal prompts and reasoning processes for large language models (LLMs) on domain-specific tasks is both necessary and challenging in real-world applications. Determining how to integrate domain knowledge, enhance reasoning…

Artificial Intelligence · Computer Science 2025-10-27 Yang Zhao , Pu Wang , Hao Frank Yang

Neurological conditions, such as Alzheimer's Disease, are challenging to diagnose, particularly in the early stages where symptoms closely resemble healthy controls. Existing brain network analysis methods primarily focus on graph-based…

Neurons and Cognition · Quantitative Biology 2025-05-20 Jiaxing Xu , Kai He , Yue Tang , Wei Li , Mengcheng Lan , Xia Dong , Yiping Ke , Mengling Feng

The Chief Complaint (CC) is a crucial component of a patient's medical record as it describes the main reason or concern for seeking medical care. It provides critical information for healthcare providers to make informed decisions about…

Computation and Language · Computer Science 2024-01-12 K M Sajjadul Islam , Ayesha Siddika Nipu , Praveen Madiraju , Priya Deshpande
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