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Motivation: Algorithms that discover variables which are causally related to a target may inform the design of experiments. With observational gene expression data, many methods discover causal variables by measuring each variable's degree…

Quantitative Methods · Quantitative Biology 2014-07-30 Eric V. Strobl , Shyam Visweswaran

Objective: The coupling between neuronal populations and its magnitude have been shown to be informative for various clinical applications. One method to estimate brain connectivity is with electroencephalography (EEG) from which the…

Computational Engineering, Finance, and Science · Computer Science 2017-05-08 Loukianos Spyrou , Mario Parra , Javier Escudero

Graphical causal models are an important tool for knowledge discovery because they can represent both the causal relations between variables and the multivariate probability distributions over the data. Once learned, causal graphs can be…

Artificial Intelligence · Computer Science 2017-04-11 Andrew J Sedgewick , Joseph D. Ramsey , Peter Spirtes , Clark Glymour , Panayiotis V. Benos

Quantifying relationships between components of a complex system is critical to understanding the rich network of interactions that characterize the behavior of the system. Traditional methods for detecting pairwise dependence of time…

Data Analysis, Statistics and Probability · Physics 2024-04-10 Aria Nguyen , Oscar McMullin , Joseph T. Lizier , Ben D. Fulcher

We describe a graphical model for probabilistic relationships---an alternative to the Bayesian network---called a dependency network. The graph of a dependency network, unlike a Bayesian network, is potentially cyclic. The probability…

Artificial Intelligence · Computer Science 2013-01-18 David Heckerman , David Maxwell Chickering , Christopher Meek , Robert Rounthwaite , Carl Kadie

Seizure detection from EEGs is a challenging and time consuming clinical problem that would benefit from the development of automated algorithms. EEGs can be viewed as structural time series, because they are multivariate time series where…

Machine Learning · Computer Science 2019-05-07 Ian Covert , Balu Krishnan , Imad Najm , Jiening Zhan , Matthew Shore , John Hixson , Ming Jack Po

It has been repeatedly conjectured that the brain retrieves statistical regularities from stimuli. Here we present a new statistical approach allowing to address this conjecture. This approach is based on a new class of stochastic processes…

Neurons and Cognition · Quantitative Biology 2018-01-15 A. Duarte , R. Fraiman , A. Galves , G. Ost , C. Vargas

This paper introduces a new framework for recovering causal graphs from observational data, leveraging the observation that the distribution of an effect, conditioned on its causes, remains invariant to changes in the prior distribution of…

Machine Learning · Computer Science 2026-02-04 Nang Hung Nguyen , Phi Le Nguyen , Thao Nguyen Truong , Trong Nghia Hoang , Masashi Sugiyama

Demystifying effective connectivity among neuronal populations has become the trend to understand the brain mechanisms of Parkinson's disease, schizophrenia, mild traumatic brain injury, and many other unlisted neurological diseases.…

Quantitative Methods · Quantitative Biology 2019-09-27 Po-Ya Hsu

Most brain disorders are very heterogeneous in terms of their underlying biology and developing analysis methods to model such heterogeneity is a major challenge. A promising approach is to use probabilistic regression methods to estimate…

Machine Learning · Statistics 2018-12-03 Seyed Mostafa Kia , Christian F. Beckmann , Andre F. Marquand

Alzheimer's disease (AD) is characterized by a sequence of pathological changes, which are commonly assessed in vivo using MRI and PET. Currently, the most approaches to analyze statistical associations between brain regions rely on Pearson…

Neurons and Cognition · Quantitative Biology 2020-03-30 Martin Dyrba , Reza Mohammadi , Michel J. Grothe , Thomas Kirste , Stefan J. Teipel

Describing the causal relations governing a system is a fundamental task in many scientific fields, ideally addressed by experimental studies. However, obtaining data under intervention scenarios may not always be feasible, while…

Methodology · Statistics 2022-05-06 Jack Kuipers , Giusi Moffa

Learning dependence relationships among variables of mixed types provides insights in a variety of scientific settings and is a well-studied problem in statistics. Existing methods, however, typically rely on copious, high quality data to…

Applications · Statistics 2019-07-25 Zehang Richard Li , Tyler H. McCormick , Samuel J. Clark

A central question in multimodal neuroimaging analysis is to understand the association between two imaging modalities and to identify brain regions where such an association is statistically significant. In this article, we propose a…

Methodology · Statistics 2024-11-28 Moyan Li , Lexin Li , Jian Kang

We formulate and analyze a graphical model selection method for inferring the conditional independence graph of a high-dimensional nonstationary Gaussian random process (time series) from a finite-length observation. The observed process…

Machine Learning · Statistics 2016-09-14 Nguyen Tran Quang , Alexander Jung

In the context of electroencephalogram (EEG)-based driver drowsiness recognition, it is still challenging to design a calibration-free system, since EEG signals vary significantly among different subjects and recording sessions. Many…

Signal Processing · Electrical Eng. & Systems 2022-02-21 Jian Cui , Zirui Lan , Olga Sourina , Wolfgang Müller-Wittig

Modelling and understanding directional gene networks is a major challenge in biology as they play an important role in the architecture and function of genetic systems. Copula Directional Dependence (CDD) can measure the directed…

Methodology · Statistics 2022-03-11 Vasiliki Vamvaka , Clara Grazian

Functional connectivity (FC) analysis of resting-state fMRI data provides a framework for characterizing brain networks and their association with participant-level covariates. Due to the high dimensionality of neuroimaging data, standard…

Methodology · Statistics 2025-08-18 Wei Zhao , Brian J. Reich , Emily C. Hector

Statistical techniques are needed to analyse data structures with complex dependencies such that clinically useful information can be extracted. Individual-specific networks, which capture dependencies in complex biological systems, are…

Methodology · Statistics 2023-08-30 Mariella Gregorich , Sean L. Simpson , Georg Heinze

We present Causal Generative Neural Networks (CGNNs) to learn functional causal models from observational data. CGNNs leverage conditional independencies and distributional asymmetries to discover bivariate and multivariate causal…