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Simulation-based inference (SBI) enables amortized Bayesian inference for simulators with implicit likelihoods. But when we are primarily interested in the quality of predictive simulations, or when the model cannot exactly reproduce the…

Machine Learning · Statistics 2023-11-03 Richard Gao , Michael Deistler , Jakob H. Macke

In real-world scenarios, although data entities may possess inherent relationships, the specific graph illustrating their connections might not be directly accessible. Latent graph inference addresses this issue by enabling Graph Neural…

Machine Learning · Computer Science 2023-11-21 Yuan Lu , Haitz Sáez de Ocáriz Borde , Pietro Liò

In this article we consider Bayesian inference for partially observed Andersson-Madigan-Perlman (AMP) Gaussian chain graph (CG) models. Such models are of particular interest in applications such as biological networks and financial time…

Methodology · Statistics 2019-08-13 Deng Lu , Maria De Iorio , Ajay Jasra , Gary L. Rosner

Perturbation experiments allow biologists to discover causal relationships between variables of interest, but the sparsity and high dimensionality of these data pose significant challenges for causal structure learning algorithms.…

Quantitative Methods · Quantitative Biology 2024-10-21 Peiwen Li , Menghua Wu

Due to their uncertainty quantification, Bayesian solutions to inverse problems are the framework of choice in applications that are risk averse. These benefits come at the cost of computations that are in general, intractable. New advances…

Machine Learning · Computer Science 2024-05-10 Rafael Orozco , Ali Siahkoohi , Mathias Louboutin , Felix J. Herrmann

We present an iterative framework to improve the amortized approximations of posterior distributions in the context of Bayesian inverse problems, which is inspired by loop-unrolled gradient descent methods and is theoretically grounded in…

Machine Learning · Computer Science 2023-05-16 Rafael Orozco , Ali Siahkoohi , Mathias Louboutin , Felix J. Herrmann

Simulation-based methods for statistical inference have evolved dramatically over the past 50 years, keeping pace with technological advancements. The field is undergoing a new revolution as it embraces the representational capacity of…

Machine Learning · Statistics 2024-10-11 Andrew Zammit-Mangion , Matthew Sainsbury-Dale , Raphaël Huser

Amortized variational inference (AVI) replaces instance-specific local inference with a global inference network. While AVI has enabled efficient training of deep generative models such as variational autoencoders (VAE), recent empirical…

Machine Learning · Statistics 2018-07-25 Yoon Kim , Sam Wiseman , Andrew C. Miller , David Sontag , Alexander M. Rush

Given observed data and a probabilistic generative model, Bayesian inference searches for the distribution of the model's parameters that could have yielded the data. Inference is challenging for large population studies where millions of…

Machine Learning · Statistics 2023-08-31 Louis Rouillard , Alexandre Le Bris , Thomas Moreau , Demian Wassermann

Amortized Bayesian inference (ABI) with neural networks has emerged as a powerful simulation-based approach for estimating complex mechanistic models. However, extending ABI to hierarchical models, a cornerstone of modern Bayesian analysis,…

Quantitative Methods · Quantitative Biology 2026-04-08 Jonas Arruda , Vikas Pandey , Catherine Sherry , Margarida Barroso , Xavier Intes , Jan Hasenauer , Stefan T. Radev

The global inducing point variational approximation for BNNs is based on using a set of inducing inputs to construct a series of conditional distributions that accurately approximate the conditionals of the true posterior distribution. Our…

Machine Learning · Statistics 2023-10-25 Matthew Ashman , Tommy Rochussen , Adrian Weller

Meta-learning is a framework in which machine learning models train over a set of datasets in order to produce predictions on new datasets at test time. Probabilistic meta-learning has received an abundance of attention from the research…

Machine Learning · Statistics 2023-09-07 Tommy Rochussen

Estimating the structure of Bayesian networks as directed acyclic graphs (DAGs) from observational data is a fundamental challenge, particularly in causal discovery. Bayesian approaches excel by quantifying uncertainty and addressing…

Machine Learning · Computer Science 2026-02-17 Edwin V. Bonilla , Pantelis Elinas , He Zhao , Maurizio Filippone , Vassili Kitsios , Terry O'Kane

Learning data representations that capture task-related features, but are invariant to nuisance variations remains a key challenge in machine learning. We introduce an automated Bayesian inference framework, called AutoBayes, that explores…

Machine Learning · Computer Science 2020-12-01 Andac Demir , Toshiaki Koike-Akino , Ye Wang , Deniz Erdogmus

Amortized Bayesian inference trains neural networks to solve stochastic inference problems using model simulations, thereby making it possible to rapidly perform Bayesian inference for any newly observed data. However, current…

Machine Learning · Computer Science 2024-07-16 Manuel Gloeckler , Michael Deistler , Christian Weilbach , Frank Wood , Jakob H. Macke

Modern Bayesian inference involves a mixture of computational techniques for estimating, validating, and drawing conclusions from probabilistic models as part of principled workflows for data analysis. Typical problems in Bayesian workflows…

Given some observed data and a probabilistic generative model, Bayesian inference aims at obtaining the distribution of a model's latent parameters that could have yielded the data. This task is challenging for large population studies…

Artificial Intelligence · Computer Science 2022-06-13 Louis Rouillard , Thomas Moreau , Demian Wassermann

Generalized Bayesian inference (GBI) is an alternative inference framework motivated by robustness to modeling errors, where a specific loss function is used to link the model parameters with observed data, instead of the log-likelihood…

Methodology · Statistics 2025-02-18 Marko Järvenpää , Jukka Corander , Henri Pesonen

Machine learning provides algorithms that can learn from data and make inferences or predictions on data. Bayesian networks are a class of graphical models that allow to represent a collection of random variables and their condititional…

Artificial Intelligence · Computer Science 2019-01-08 Robert Leppert , Karl-Heinz Zimmermann

Intelligence is fundamentally non-ergodic: it emerges not from uniform sampling or optimization from scratch, but from the structured reuse of prior inference trajectories. We introduce Memory-Amortized Inference (MAI) as a formal framework…

Machine Learning · Computer Science 2025-08-21 Xin Li