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Pathological diagnosis remains the definitive standard for identifying tumors. The rise of multimodal large models has simplified the process of integrating image analysis with textual descriptions. Despite this advancement, the substantial…

Computer Vision and Pattern Recognition · Computer Science 2024-08-14 Xiaomin Wu , Rui Xu , Pengchen Wei , Wenkang Qin , Peixiang Huang , Ziheng Li , Lin Luo

We introduce ProtoPathway, an interpretable-by-design multimodal framework for cancer survival prediction that unifies whole slide imaging and transcriptomics through encoders producing biologically grounded representations on both sides of…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Amaya Gallagher-Syed , Costantino Pitzalis , Myles J. Lewis , Michael R. Barnes , Gregory Slabaugh

Competency Questions (CQs) for an ontology and similar artefacts aim to provide insights into the contents of an ontology and to demarcate its scope. The absence of a controlled natural language, tooling and automation to support the…

Artificial Intelligence · Computer Science 2019-07-18 C. Maria Keet , Zola Mahlaza , Mary-Jane Antia

Few-shot learning presents a critical solution for cancer diagnosis in computational pathology (CPath), addressing fundamental limitations in data availability, particularly the scarcity of expert annotations and patient privacy…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Zhengrui Guo , Conghao Xiong , Jiabo Ma , Qichen Sun , Lishuang Feng , Jinzhuo Wang , Hao Chen

Vision-language models (VLMs) have the potential to become co-pilots for pathologists. However, most VLMs either focus on small regions of interest within whole-slide images, provide only static slide-level outputs, or rely on data that is…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Sander Moonemans , Sebastiaan Ram , Frédérique Meeuwsen , Carlijn Lems , Jeroen van der Laak , Geert Litjens , Francesco Ciompi

Lifelong learning on Whole Slide Images (WSIs) aims to train or fine-tune a unified model sequentially on cancer-related tasks, reducing the resources and effort required for data transfer and processing, especially given the gigabyte-scale…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Doanh C. Bui , Ba Hung Ngo , Hoai Luan Pham , Khang Nguyen , Maï K. Nguyen , Yasuhiko Nakashima

The exponential growth of AI in science necessitates efficient and scalable solutions for retrieving and preserving research information. Here, we present a tool for the development of a customized question-answer (QA) dataset, called…

Information Retrieval · Computer Science 2025-02-25 Qiming Liu , Zhongzheng Niu , Siting Liu , Mao Tian

Accurate carotid plaque grading (CPG) is vital to assess the risk of cardiovascular and cerebrovascular diseases. Due to the small size and high intra-class variability of plaque, CPG is commonly evaluated using a combination of transverse…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Zhiyuan Zhu , Jian Wang , Yong Jiang , Tong Han , Yuhao Huang , Ang Zhang , Kaiwen Yang , Mingyuan Luo , Zhe Liu , Yaofei Duan , Dong Ni , Tianhong Tang , Xin Yang

Recent progress in Large Vision-Language Models (LVLMs) has enabled promising applications in medical tasks, such as report generation and visual question answering. However, existing benchmarks focus mainly on the final diagnostic answer,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Hyungyung Lee , Geon Choi , Jung-Oh Lee , Hangyul Yoon , Hyuk Gi Hong , Edward Choi

Tabular data embedded in PDF files, web pages, and other types of documents is prevalent in various domains. These tables, which we call human-centric tables (HCTs for short), are dense in information but often exhibit complex structural…

Breast cancer survival prediction in computational pathology presents a remarkable challenge due to tumor heterogeneity. For instance, different regions of the same tumor in the pathology image can show distinct morphological and molecular…

Image and Video Processing · Electrical Eng. & Systems 2025-03-25 Yang Luo , Shiru Wang , Jun Liu , Jiaxuan Xiao , Rundong Xue , Zeyu Zhang , Hao Zhang , Yu Lu , Yang Zhao , Yutong Xie

Presenting whole slide images (WSIs) as graph will enable a more efficient and accurate learning framework for cancer diagnosis. Due to the fact that a single WSI consists of billions of pixels and there is a lack of vast annotated datasets…

Image and Video Processing · Electrical Eng. & Systems 2023-06-09 Milan Aryal , Nasim Yahyasoltani

Identifying causal interactions in complex dynamical systems is a fundamental challenge across the computational sciences. Existing functional connectivity methods capture correlations but not causation. While addressing directionality,…

Neurons and Cognition · Quantitative Biology 2026-03-10 Rahul Biswas , SuryaNarayana Sripada , Somabha Mukherjee , Reza Abbasi-Asl

Accurate and timely cancer diagnosis from histopathological slides is vital for effective clinical decision-making. This paper introduces DepViT-CAD, a deployable AI system for multi-class cancer diagnosis in histopathology. At its core is…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Ashkan Shakarami , Lorenzo Nicole , Rocco Cappellesso , Angelo Paolo Dei Tos , Stefano Ghidoni

Clinical practice guidelines (CPGs) play a pivotal role in ensuring evidence-based decision-making and improving patient outcomes. While Large Language Models (LLMs) are increasingly deployed in healthcare scenarios, it is unclear to which…

Computation and Language · Computer Science 2026-03-27 Andong Tan , Shuyu Dai , Jinglu Wang , Fengtao Zhou , Yan Lu , Xi Wang , Yingcong Chen , Can Yang , Shujie Liu , Hao Chen

Brain tumor diagnosis is largely dependent on Magnetic Resonance Imaging (MRI) evaluation, which requires radiologists to synthesize thousands of images across multiple 3D sequences and longitudinal studies. This process requires advanced…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Shiv Ghosh , Junayd Lateef , Chih-Hua Liu , Yannan Yu , Andreas M. Rauschecker , Madhumita Sushil

Existing WSI analysis methods lie on the consensus that histopathological characteristics of tumors are significant guidance for cancer diagnostics. Particularly, as the evolution of cancers is a continuous process, the correlations and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Tong Shu , Jun Shi , Dongdong Sun , Zhiguo Jiang , Yushan Zheng

Personalized diagnoses have not been possible due to sear amount of data pathologists have to bear during the day-to-day routine. This lead to the current generalized standards that are being continuously updated as new findings are…

Computer Vision and Pattern Recognition · Computer Science 2021-10-27 Jialun Wu , Zeyu Gao , Haichuan Zhang , Ruonan Zhang , Tieliang Gong , Chunbao Wang , Chen Li

Rare cancers comprise 20-25% of all malignancies but face major diagnostic challenges due to limited expert availability-especially in pediatric oncology, where they represent over 70% of cases. While pathology vision-language (VL)…

Computer Vision and Pattern Recognition · Computer Science 2025-08-25 Dexuan He , Xiao Zhou , Wenbin Guan , Liyuan Zhang , Xiaoman Zhang , Sinuo Xu , Ge Wang , Lifeng Wang , Xiaojun Yuan , Xin Sun , Yanfeng Wang , Kun Sun , Ya Zhang , Weidi Xie

Despite the growing adoption of electronic health records, many processes still rely on paper documents, reflecting the heterogeneous real-world conditions in which healthcare is delivered. The manual transcription process is time-consuming…