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Understanding the biological mechanisms of disease is crucial for medicine, and in particular, for drug discovery. AI-powered analysis of genome-scale biological data holds great potential in this regard. The increasing availability of…

We introduce a novel visual tokenization framework that embeds a provable PCA-like structure into the latent token space. While existing visual tokenizers primarily optimize for reconstruction fidelity, they often neglect the structural…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Xin Wen , Bingchen Zhao , Ismail Elezi , Jiankang Deng , Xiaojuan Qi

Detection of visual anomalies refers to the problem of finding patterns in different imaging data that do not conform to the expected visual appearance and is a widely studied problem in different domains. Due to the nature of anomaly…

Image and Video Processing · Electrical Eng. & Systems 2021-04-29 Dejan Stepec , Danijel Skocaj

Single-cell proteomics (SCP) is transforming our understanding of biological complexity by shifting from bulk proteomics, where signals are averaged over thousands of cells, to the proteome analysis of individual cells. This granular…

Quantitative Methods · Quantitative Biology 2025-04-01 Amanda Momenzadeh , Jesse G. Meyer

Single-cell data integration can provide a comprehensive molecular view of cells, and many algorithms have been developed to remove unwanted technical or biological variations and integrate heterogeneous single-cell datasets. Despite their…

Quantitative Methods · Quantitative Biology 2024-03-04 Rong Ma , Eric D. Sun , David Donoho , James Zou

With the advance of experimental techniques such as time-lapse fluorescence microscopy, the availability of single-cell trajectory data has vastly increased, and so has the demand for computational methods suitable for parameter inference…

Quantitative Methods · Quantitative Biology 2016-07-06 Irena Kuzmanovska , Andreas Milias-Argeitis , Christoph Zechner , Mustafa Khammash

Developments in transcriptomics techniques have caused a large demand in tailored computational methods for modelling gene expression dynamics from experimental data. Recently, so-called single-cell experiments have revolutionised genetic…

Quantitative Methods · Quantitative Biology 2019-03-18 Atte Aalto , Jorge Goncalves

Single-cell reference atlases are large-scale, cell-level maps that capture cellular heterogeneity within an organ using single cell genomics. Given their size and cellular diversity, these atlases serve as high-quality training data for…

Genomics · Quantitative Biology 2022-11-09 Jan Engelmann , Leon Hetzel , Giovanni Palla , Lisa Sikkema , Malte Luecken , Fabian Theis

The rapid growth of deep learning (DL) has spurred interest in enhancing log-based anomaly detection. This approach aims to extract meaning from log events (log message templates) and develop advanced DL models for anomaly detection.…

Machine Learning · Computer Science 2024-02-01 Lin Yang , Junjie Chen , Shutao Gao , Zhihao Gong , Hongyu Zhang , Yue Kang , Huaan Li

As data continues to grow in volume and complexity across domains such as finance, manufacturing, and healthcare, effective anomaly detection is essential for identifying irregular patterns that may signal critical issues. Recently,…

Machine Learning · Computer Science 2025-06-16 Jing Ren , Tao Tang , Hong Jia , Ziqi Xu , Haytham Fayek , Xiaodong Li , Suyu Ma , Xiwei Xu , Feng Xia

Medical anomaly detection aims to identify abnormal findings using only normal training data, playing a crucial role in health screening and recognizing rare diseases. Reconstruction-based methods, particularly those utilizing autoencoders…

Machine Learning · Computer Science 2024-07-10 Yu Cai , Hao Chen , Kwang-Ting Cheng

This work presents a novel approach for selecting the optimal ensemble-based classification method and features with a primarly focus on achieving generalization, based on the state-of-the-art, to provide diagnostic support for Sickle Cell…

Machine Learning · Computer Science 2026-01-21 Nataša Petrović , Gabriel Moyà-Alcover , Antoni Jaume-i-Capó , Jose Maria Buades Rubio

Single-cell-resolution spatial transcriptomics profiles gene expression at cellular locations in native tissues, yet accurate cell-type annotation remains challenging: imaging-based platforms are constrained by targeted gene panels, whereas…

Cell Behavior · Quantitative Biology 2026-05-27 Yiyang Zhang , Bokai Zhao , Xiaoru Zhang , Zongchang Du , Xiaojuan Sun , Tianzi Jiang

While new and effective methods for anomaly detection are frequently introduced, many studies prioritize the detection task without considering the need for explainability. Yet, in real-world applications, anomaly explanation, which aims to…

Machine Learning · Computer Science 2023-12-19 Cheng Feng

We introduce Time-Conditioned Contraction Matching (TCCM), a novel method for semi-supervised anomaly detection in tabular data. TCCM is inspired by flow matching, a recent generative modeling framework that learns velocity fields between…

Machine Learning · Computer Science 2025-10-22 Zhong Li , Qi Huang , Yuxuan Zhu , Lincen Yang , Mohammad Mohammadi Amiri , Niki van Stein , Matthijs van Leeuwen

The rapidly growing field of single-cell transcriptomic sequencing (scRNAseq) presents challenges for data analysis due to its massive datasets. A common method in manifold learning consists in hypothesizing that datasets lie on a lower…

Uncertain data streams have been widely generated in many Web applications. The uncertainty in data streams makes anomaly detection from sensor data streams far more challenging. In this paper, we present a novel framework that supports…

Artificial Intelligence · Computer Science 2016-07-21 Jiangang Ma , Le Sun , Hua Wang , Yanchun Zhang , Uwe Aickelin

Semi-supervised Learning plays a crucial role in network anomaly detection applications, however, learning anomaly patterns with limited labeled samples is not easy. Additionally, the lack of interpretability creates key barriers to the…

Machine Learning · Computer Science 2025-11-11 Yachao Yuan , Yu Huang , Yingwen Wu , Jin Wang

Anomaly detection (AD) has been extensively studied and applied in a wide range of scenarios in the recent past. However, there are still gaps between achieved and desirable levels of recognition accuracy for making AD for practical…

Computer Vision and Pattern Recognition · Computer Science 2024-06-10 Peng Xing , Dong Zhang , Jinhui Tang , Zechao li

Deep neural networks (DNNs) are notoriously hard to understand and difficult to defend. Extracting representative paths (including the neuron activation values and the connections between neurons) from DNNs using software engineering…

Machine Learning · Computer Science 2025-05-22 Fangzhen Zhao , Chenyi Zhang , Naipeng Dong , Ming Li , Jinxiao Shan
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