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Early and accurate diagnosis of Alzheimer's disease (AD) remains a critical challenge in neuroimaging-based clinical decision support systems. In this work, we propose a novel hybrid deep learning framework that integrates Topological Data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Faisal Ahmed

Now that disease-modifying therapies for Alzheimer disease have been approved by regulatory agencies, the early, objective, and accurate clinical diagnosis of AD based on the lowest-cost measurement modalities possible has become an…

Image and Video Processing · Electrical Eng. & Systems 2025-11-13 Faisal Ahmed , Taymaz Akan , Fatih Gelir , Owen T. Carmichael , Elizabeth A. Disbrow , Steven A. Conrad , Mohammad A. N. Bhuiyan

Brain network topology, derived from functional magnetic resonance imaging (fMRI), holds promise for improving Alzheimer's disease (AD) diagnosis. Current methods primarily focus on lower-order topological features, often overlooking the…

Geometric Topology · Mathematics 2025-09-19 Dengyi Zhao , Shanyong Li , Yunping Wang , Chenfei Wang , Zhiheng Zhou , Guiying Yan , Xingqin Qi

Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…

Image and Video Processing · Electrical Eng. & Systems 2021-07-29 Fan Zhang , Bo Pan , Pengfei Shao , Peng Liu , Shuwei Shen , Peng Yao , Ronald X. Xu

Recently, machine learning techniques especially predictive modeling and pattern recognition in biomedical sciences from drug delivery system to medical imaging has become one of the important methods which are assisting researchers to have…

Computer Vision and Pattern Recognition · Computer Science 2017-05-23 Saman Sarraf , Ghassem Tofighi

Over the past decade, machine learning techniques especially predictive modeling and pattern recognition in biomedical sciences from drug delivery system to medical imaging has become one of the important methods which are assisting…

Computer Vision and Pattern Recognition · Computer Science 2016-03-30 Saman Sarraf , Ghassem Tofighi

Alzheimer's Disease destroys brain cells causing people to lose their memory, mental functions and ability to continue daily activities. It is a severe neurological brain disorder which is not curable, but earlier detection of Alzheimer's…

Computer Vision and Pattern Recognition · Computer Science 2017-12-21 Jyoti Islam , Yanqing Zhang

A common neurodegenerative disease, Alzheimer's disease requires a precise diagnosis and efficient treatment, particularly in light of escalating healthcare expenses and the expanding use of artificial intelligence in medical diagnostics.…

Image and Video Processing · Electrical Eng. & Systems 2025-05-21 Soyabul Islam Lincoln , Mirza Mohd Shahriar Maswood

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan

Deep learning, a cutting-edge machine learning approach, outperforms traditional machine learning in identifying intricate structures in complex high-dimensional data, particularly in the domain of healthcare. This study focuses on…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Nida Nasir , Muneeb Ahmed , Neda Afreen , Mustafa Sameer

The most frequent kind of dementia of the nervous system, Alzheimer's disease, weakens several brain processes (such as memory) and eventually results in death. The clinical study uses magnetic resonance imaging to diagnose AD. Deep…

Image and Video Processing · Electrical Eng. & Systems 2023-10-30 Sarasadat Foroughipoor , Kimia Moradi , Hamidreza Bolhasani

Alzheimer's Disease is a devastating neurological disorder that is increasingly affecting the elderly population. Early and accurate detection of Alzheimer's is crucial for providing effective treatment and support for patients and their…

Image and Video Processing · Electrical Eng. & Systems 2023-04-27 Krishna Mahapatra , Selvakumar R

Alzheimer's disease (AD) is a progressive brain disorder that causes memory and functional impairments. The advances in machine learning and publicly available medical datasets initiated multiple studies in AD diagnosis. In this work, we…

Image and Video Processing · Electrical Eng. & Systems 2021-07-20 Aidana Massalimova , Huseyin Atakan Varol

Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disease which destroys brain cells and causes loss to patient's memory. An early detection can prevent the patient from further damage of the brain cells and hence…

Image and Video Processing · Electrical Eng. & Systems 2021-01-11 Ali Nawaz , Syed Muhammad Anwar , Rehan Liaqat , Javid Iqbal , Ulas Bagci , Muhammad Majid

Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects cognitive functions such as memory, thinking, and behavior. In this disease, there is a critical phase, mild cognitive impairment, that is really…

Signal Processing · Electrical Eng. & Systems 2024-04-02 Arezoo Borji , Taha-Hossein Hejazi , Abbas Seifi

Alzheimers Disease (AD) is a progressive neurodegenerative disorder that poses significant challenges in its early diagnosis, often leading to delayed treatment and poorer outcomes for patients. Traditional diagnostic methods, typically…

Machine Learning · Computer Science 2025-08-06 Tatwadarshi P Nagarhalli , Sanket Patil , Vishal Pande , Uday Aswalekar , Prafulla Patil

Deep learning has shown outstanding performance in identifying intricate structures in complex high-dimensional data, especially in the domain of computer vision. The application of deep learning to early detection and automated…

Image and Video Processing · Electrical Eng. & Systems 2019-08-22 Taeho Jo , Kwangsik Nho , Andrew J. Saykin

The assessment of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) associated with brain changes remains a challenging task. Recent studies have demonstrated that combination of multi-modality imaging techniques can better…

Machine Learning · Computer Science 2022-09-26 Jun Yu , Zhaoming Kong , Liang Zhan , Li Shen , Lifang He

Alzheimer Disease poses a significant challenge, necessitating early detection for effective intervention. MRI is a key neuroimaging tool due to its ease of use and cost effectiveness. This study analyzes machine learning methods for MRI…

Neurons and Cognition · Quantitative Biology 2024-08-12 Alwani Liyana Ahmad , Jose Sanchez-Bornot , Roberto C. Sotero , Damien Coyle , Zamzuri Idris , Ibrahima Faye

Computer-aided early diagnosis of Alzheimers Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research in recent years. Some recent studies have shown promising results in the AD and…

Computer Vision and Pattern Recognition · Computer Science 2018-01-19 Alexander Khvostikov , Karim Aderghal , Jenny Benois-Pineau , Andrey Krylov , Gwenaelle Catheline
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