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The application of natural language processing (NLP) to cancer pathology reports has been focused on detecting cancer cases, largely ignoring precancerous cases. Improving the characterization of precancerous adenomas assists in developing…

Machine Learning · Computer Science 2022-12-13 Yizhen Zhong , Jiajie Xiao , Thomas Vetterli , Mahan Matin , Ellen Loo , Jimmy Lin , Richard Bourgon , Ofer Shapira

Automating data extraction from clinical documents offers significant potential to improve efficiency in healthcare settings, yet deploying Natural Language Processing (NLP) solutions presents practical challenges. Drawing upon our…

Computation and Language · Computer Science 2025-08-18 Lovedeep Gondara , Gregory Arbour , Raymond Ng , Jonathan Simkin , Shebnum Devji

Processing information locked within clinical health records is a challenging task that remains an active area of research in biomedical NLP. In this work, we evaluate a broad set of machine learning techniques ranging from simple RNNs to…

Objective: To develop a natural language processing (NLP) system to extract medications and contextual information that help understand drug changes. This project is part of the 2022 n2c2 challenge. Materials and methods: We developed NLP…

Computation and Language · Computer Science 2023-05-10 Aokun Chen , Zehao Yu , Xi Yang , Yi Guo , Jiang Bian , Yonghui Wu

Background: Population-based cancer registries (PBCRs) manually extract data from unstructured pathology reports, a labor-intensive process where assigning reports to tumor groups can consume 900 person-hours annually for approximately…

Computation and Language · Computer Science 2026-03-20 Lovedeep Gondara , Jonathan Simkin , Shebnum Devji , Gregory Arbour , Raymond Ng

There is an increasing interest in developing artificial intelligence (AI) systems to process and interpret electronic health records (EHRs). Natural language processing (NLP) powered by pretrained language models is the key technology for…

Objective: The majority of detailed patient information in real-world data (RWD) is only consistently available in free-text clinical documents. Manual curation is expensive and time-consuming. Developing natural language processing (NLP)…

Objective: This review aims to analyze the application of natural language processing (NLP) techniques in cancer research using electronic health records (EHRs) and clinical notes. This review addresses gaps in the existing literature by…

Computation and Language · Computer Science 2025-02-05 Muhammad Bilal , Ameer Hamza , Nadia Malik

Both medical care and observational studies in oncology require a thorough understanding of a patient's disease progression and treatment history, often elaborately documented in clinical notes. Despite their vital role, no current oncology…

Computation and Language · Computer Science 2024-03-18 Madhumita Sushil , Vanessa E. Kennedy , Divneet Mandair , Brenda Y. Miao , Travis Zack , Atul J. Butte

Clinical oncology generates vast, unstructured data that often contain inconsistencies, missing information, and ambiguities, making it difficult to extract reliable insights for data-driven decision-making. General-purpose large language…

Computation and Language · Computer Science 2025-03-12 Morteza Rohanian , Tarun Mehra , Nicola Miglino , Farhad Nooralahzadeh , Michael Krauthammer , Andreas Wicki

NLP-based computer vision models, particularly vision transformers, have been shown to outperform CNN models in many imaging tasks. However, most digital pathology artificial-intelligence models are based on CNN architectures, probably…

Computation and Language · Computer Science 2023-02-22 Min Cen , Xingyu Li , Bangwei Guo , Jitendra Jonnagaddala , Hong Zhang , Xu Steven Xu

Gene enhancers control when and where genes switch on, yet their sequence diversity and tissue specificity make them hard to pinpoint in colorectal cancer. We take a sequence-only route and fine-tune DNABERT-2, a transformer genomic…

Genomics · Quantitative Biology 2025-10-01 Darren King , Yaser Atlasi , Gholamreza Rafiee

Pathology text mining is a challenging task given the reporting variability and constant new findings in cancer sub-type definitions. However, successful text mining of a large pathology database can play a critical role to advance 'big…

Computation and Language · Computer Science 2022-05-17 Thiago Santos , Amara Tariq , Susmita Das , Kavyasree Vayalpati , Geoffrey H. Smith , Hari Trivedi , Imon Banerjee

Natural Language Processing (NLP) is a key technique for developing Medical Artificial Intelligence (AI) systems that leverage Electronic Health Record (EHR) data to build diagnostic and prognostic models. NLP enables the conversion of…

Objective: The generalizability of clinical large language models is usually ignored during the model development process. This study evaluated the generalizability of BERT-based clinical NLP models across different clinical settings…

Computation and Language · Computer Science 2023-03-16 Sicheng Zhou , Nan Wang , Liwei Wang , Ju Sun , Anne Blaes , Hongfang Liu , Rui Zhang

The National Comprehensive Cancer Network (NCCN) provides evidence-based guidelines for cancer treatment. Translating complex patient presentations into guideline-compliant treatment recommendations is time-intensive, requires specialized…

The purpose of this study is to analyze the efficacy of transfer learning techniques and transformer-based models as applied to medical natural language processing (NLP) tasks, specifically radiological text classification. We used 1,977…

Computation and Language · Computer Science 2020-02-19 Daniel Ranti , Katie Hanss , Shan Zhao , Varun Arvind , Joseph Titano , Anthony Costa , Eric Oermann

The clinical integration of deep learning models for brain tumor diagnosis in neuro-oncology is severely constrained by limited expert-annotated MRI data and substantial inter-institutional domain shift arising from variations in scanners,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Sapna Sachan , Amulya Kumar Mahto , Prashant Wagambar Patil

Recent progress in natural language processing has been impressive in many different areas with transformer-based approaches setting new benchmarks for a wide range of applications. This development has also lowered the barriers for people…

Computation and Language · Computer Science 2022-04-07 Miriam Schirmer , Udo Kruschwitz , Gregor Donabauer

PURPOSE: The medical literature relevant to germline genetics is growing exponentially. Clinicians need tools monitoring and prioritizing the literature to understand the clinical implications of the pathogenic genetic variants. We…

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