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Communication of information in complex systems can be considered as major driver of systems evolution. What matters is not the communicated information by itself but rather the meaning that is supplied to the information. However…

Computers and Society · Computer Science 2023-04-28 Inga Ivanova

In this paper we show that living cells can multiplex biochemical signals, i.e. transmit multiple signals through the same signaling pathway simultaneously, and yet respond to them very specifically. We demonstrate how two binary input…

Molecular Networks · Quantitative Biology 2012-06-01 Wiet de Ronde , Filipe Tostevin , Pieter Rein ten Wolde

Biological information processing manifests a huge variety in its complexity and capability among different organisms, which presumably stems from the evolutionary optimization under limited computational resources. Starting from the…

Biological Physics · Physics 2025-10-21 Takehiro Tottori , Tetsuya J. Kobayashi

Humans communicate using systems of interconnected stimuli or concepts -- from language and music to literature and science -- yet it remains unclear how, if at all, the structure of these networks supports the communication of information.…

Physics and Society · Physics 2020-03-27 Christopher W. Lynn , Lia Papadopoulos , Ari E. Kahn , Danielle S. Bassett

A common feature of biological networks is the geometric property of self-similarity. Molecular regulatory networks through to circulatory systems, nervous systems, social systems and ecological trophic networks, show self-similar…

Molecular Networks · Quantitative Biology 2012-03-09 Simon DeDeo , David C. Krakauer

Living organisms survive and multiply even though they have uncertain and incomplete information about their environment and imperfect models to predict the consequences of their actions. Bayesian models have been proposed to face this…

Emerging Technologies · Computer Science 2015-11-13 Jacques Droulez , David Colliaux , Audrey Houillon , Pierre Bessière

Ambiguous questions are a challenge for Question Answering models, as they require answers that cover multiple interpretations of the original query. To this end, these models are required to generate long-form answers that often combine…

Computation and Language · Computer Science 2023-05-23 Konstantinos Papakostas , Irene Papadopoulou

This paper develops a theory of learning under ambiguity induced by the decision maker's beliefs about the collection of data correlated with the true state of the world. Within our framework, two classical results on Bayesian learning…

Theoretical Economics · Economics 2026-02-10 Cheaheon Lim

Statistical properties of environments experienced by biological signaling systems in the real world change, which necessitate adaptive responses to achieve high fidelity information transmission. One form of such adaptive response is gain…

Molecular Networks · Quantitative Biology 2012-05-01 Ilya Nemenman

Cooperative interactions among the binding of multiple signaling molecules is a common mechanism for enhancing the sensitivity of biological signaling systems. It is widely assumed that this increase in sensitivity of the mean response…

Molecular Networks · Quantitative Biology 2007-05-23 William Bialek , Sima Setayeshgar

A network of agents attempt to learn some unknown state of the world drawn by nature from a finite set. Agents observe private signals conditioned on the true state, and form beliefs about the unknown state accordingly. Each agent may face…

Machine Learning · Computer Science 2015-03-13 Shahin Shahrampour , Mohammad Amin Rahimian , Ali Jadbabaie

Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn modulate the expression levels of the genes under their control and sometimes need…

Molecular Networks · Quantitative Biology 2013-08-01 Gasper Tkacik , Curtis G Callan , William Bialek

What happens to the optimal interpretation of noisy data when there exists more than one equally plausible interpretation of the data? In a Bayesian model-learning framework the answer depends on the prior expectations of the dynamics of…

Other Quantitative Biology · Quantitative Biology 2007-05-23 Gurinder Singh Atwal , William Bialek

We typically think of cells as responding to external signals independently by regulating their gene expression levels, yet they often locally exchange information and coordinate. Can such spatial coupling be of benefit for conveying…

Molecular Networks · Quantitative Biology 2015-01-19 Thomas R. Sokolowski , Gašper Tkačik

Given a pair of predictor variables and a response variable, how much information do the predictors have about the response, and how is this information distributed between unique, redundant, and synergistic components? Recent work has…

Information Theory · Computer Science 2018-10-29 Pradeep Kr. Banerjee , Johannes Rauh , Guido Montúfar

Many natural and artificial two-states signaling devices are connected forming networks. The information-processing potential of these systems is usually related to the response to weak external signals. Here, using a network of overdamped…

Computational Physics · Physics 2007-09-24 Juan A. Acebron , Sergi Lozano , Alex Arenas

We model the communication of narratives as a cheap-talk game under model uncertainty. The sender has private information about the true data generating process of publicly observable data. The receiver is uncertain about how to interpret…

Theoretical Economics · Economics 2025-07-09 Gerrit Bauch , Manuel Foerster

It often is emphasized that gene expression is noisy. A seemingly contradictory view is that control mechanisms have been optimized to squeeze as much information as possible out of a limited number of molecules. Here we revisit these…

Biological Physics · Physics 2025-12-17 Nicholas Lawson , William Bialek

Human sociality depends upon the benefits of mutual aid and extensive communication. However mutual aid is made difficult by the problems of coordinating diverse norms and preferences, and communication is harried by substantial ambiguity…

Physics and Society · Physics 2015-11-17 Paul E. Smaldino , Thomas J. Flamson , Richard McElreath

Ambiguity is an critical component of language that allows for more effective communication between speakers, but is often ignored in NLP. Recent work suggests that NLP systems may struggle to grasp certain elements of human language…

Computation and Language · Computer Science 2024-03-22 Margaret Y. Li , Alisa Liu , Zhaofeng Wu , Noah A. Smith