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Large language models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence technology which is rapidly evolving and promises to aid in medical diagnosis. However, the correctness and the accuracy of their returns has…

Computation and Language · Computer Science 2024-02-07 Dimitrios P. Panagoulias , Maria Virvou , George A. Tsihrintzis

Diabetic retinopathy (DR) is a leading cause of blindness worldwide, and AI systems can expand access to fundus photography screening. Current FDA-cleared systems primarily provide binary referral outputs, where this minimal output may…

Artificial Intelligence · Computer Science 2025-09-17 Nadim Barakat , William Lotter

Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation across various domains, including medicine. We present a comprehensive evaluation of GPT-4, a state-of-the-art LLM, on…

Computation and Language · Computer Science 2023-04-13 Harsha Nori , Nicholas King , Scott Mayer McKinney , Dean Carignan , Eric Horvitz

Introduction: With the rapid advances in large language models (LLMs), there have been numerous new open source as well as commercial models. While recent publications have explored GPT-4 in its application to extracting information of…

Although supervised machine learning is popular for information extraction from clinical notes, creating large annotated datasets requires extensive domain expertise and is time-consuming. Meanwhile, large language models (LLMs) have…

Computation and Language · Computer Science 2024-01-26 Madhumita Sushil , Travis Zack , Divneet Mandair , Zhiwei Zheng , Ahmed Wali , Yan-Ning Yu , Yuwei Quan , Atul J. Butte

The recent swift development of LLMs like GPT-4, Gemini, and GPT-3.5 offers a transformative opportunity in medicine and healthcare, especially in digital diagnostics. This study evaluates each model diagnostic abilities by interpreting a…

Computation and Language · Computer Science 2024-05-14 Gaurav Kumar Gupta , Aditi Singh , Sijo Valayakkad Manikandan , Abul Ehtesham

The application of large language models (LLMs) to healthcare information extraction has emerged as a promising approach. This study evaluates the classification performance of five open-source LLMs: GEMMA-3-27B-IT, LLAMA3-70B, LLAMA4-109B,…

Computation and Language · Computer Science 2025-05-09 Yuting Guo , Abeed Sarker

Recent developments in multimodal large language models (MLLMs) have spurred significant interest in their potential applications across various medical imaging domains. On the one hand, there is a temptation to use these generative models…

Image and Video Processing · Electrical Eng. & Systems 2024-06-05 Sulaiman Khan , Md. Rafiul Biswas , Alina Murad , Hazrat Ali , Zubair Shah

Recent work has shown promising performance of frontier large language models (LLMs) and their multimodal counterparts in medical quizzes and diagnostic tasks, highlighting their potential for broad clinical utility given their accessible,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Advait Gosai , Arun Kavishwar , Stephanie L. McNamara , Soujanya Samineni , Renato Umeton , Alexander Chowdhury , William Lotter

Large Language Models (LLMs) have shown significant promise across various natural language processing tasks. However, their application in the field of pathology, particularly for extracting meaningful insights from unstructured medical…

Computation and Language · Computer Science 2025-03-04 Rachit Saluja , Jacob Rosenthal , Yoav Artzi , David J. Pisapia , Benjamin L. Liechty , Mert R. Sabuncu

Purpose: To assess the alignment of GPT-4-based evaluation to human clinician experts, for the evaluation of responses to ophthalmology-related patient queries generated by fine-tuned LLM chatbots. Methods: 400 ophthalmology questions and…

Artificial Intelligence · Computer Science 2024-02-16 Ting Fang Tan , Kabilan Elangovan , Liyuan Jin , Yao Jie , Li Yong , Joshua Lim , Stanley Poh , Wei Yan Ng , Daniel Lim , Yuhe Ke , Nan Liu , Daniel Shu Wei Ting

Medical images and radiology reports are crucial for diagnosing medical conditions, highlighting the importance of quantitative analysis for clinical decision-making. However, the diversity and cross-source heterogeneity of these data…

Image and Video Processing · Electrical Eng. & Systems 2024-07-09 Yutong Zhang , Yi Pan , Tianyang Zhong , Peixin Dong , Kangni Xie , Yuxiao Liu , Hanqi Jiang , Zhengliang Liu , Shijie Zhao , Tuo Zhang , Xi Jiang , Dinggang Shen , Tianming Liu , Xin Zhang

Large language models (LLMs) can simulate clinical reasoning based on natural language prompts, but their utility in ophthalmology is largely unexplored. This study evaluated GPT-4's ability to interpret structured textual descriptions of…

Computation and Language · Computer Science 2025-07-03 Cindy Lie Tabuse , David Restepo , Carolina Gracitelli , Fernando Korn Malerbi , Caio Regatieri , Luis Filipe Nakayama

Background: Large language models (LLMs) such as OpenAI's GPT-4 or Google's PaLM 2 are proposed as viable diagnostic support tools or even spoken of as replacements for "curbside consults". However, even LLMs specifically trained on medical…

Artificial Intelligence · Computer Science 2024-10-21 Gioele Barabucci , Victor Shia , Eugene Chu , Benjamin Harack , Nathan Fu

The recent success of large language models (LLMs) has paved the way for their adoption in the high-stakes domain of healthcare. Specifically, the application of LLMs in patient-trial matching, which involves assessing patient eligibility…

Artificial Intelligence · Computer Science 2023-12-18 Mauro Nievas , Aditya Basu , Yanshan Wang , Hrituraj Singh

Recent advances in multimodal large language models enable new possibilities for image-based decision support. However, their reliability and operational trade-offs in neuroimaging remain insufficiently understood. We present a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Katarina Trojachanec Dineva , Stefan Andonov , Ilinka Ivanoska , Ivan Kitanovski , Sasho Gramatikov , Tamara Kostova , Monika Simjanoska Misheva , Kostadin Mishev

Automation in agriculture plays a vital role in addressing challenges related to crop monitoring and disease management, particularly through early detection systems. This study investigates the effectiveness of combining multimodal Large…

Computer Vision and Pattern Recognition · Computer Science 2025-04-30 Konstantinos I. Roumeliotis , Ranjan Sapkota , Manoj Karkee , Nikolaos D. Tselikas , Dimitrios K. Nasiopoulos

While Machine Learning (ML) and Deep Learning (DL) models have been widely used for diabetes prediction, the use of Large Language Models (LLMs) for structured numerical data is still not well explored. In this study, we test the…

Computation and Language · Computer Science 2025-06-19 Shadman Sakib , Oishy Fatema Akhand , Ajwad Abrar

Large language models (LLMs) have made significant advancements in natural language processing (NLP). Broad corpora capture diverse patterns but can introduce irrelevance, while focused corpora enhance reliability by reducing misleading…

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

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