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Deep learning models have gained increasing adoption in medical image analysis. However, these models often produce overconfident predictions, which can compromise clinical accuracy and reliability. Bridging the gap between high-performance…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Jutika Borah , Hidam Kumarjit Singh

In recent years, colorectal cancer has become one of the most significant diseases that endanger human health. Deep learning methods are increasingly important for the classification of colorectal histopathology images. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2022-06-08 Haoyuan Chen , Chen Li , Xiaoyan Li , Md Mamunur Rahaman , Weiming Hu , Yixin Li , Wanli Liu , Changhao Sun , Hongzan Sun , Xinyu Huang , Marcin Grzegorzek

With the increasing demand for histopathological specimen examination and diagnostic reporting, Multiple Instance Learning (MIL) has received heightened research focus as a viable solution for AI-centric diagnostic aid. Recently, to improve…

Computer Vision and Pattern Recognition · Computer Science 2025-12-25 Sungrae Hong , Sol Lee , Jisu Shin , Jiwon Jeong , Mun Yong Yi

Digital pathology based on whole slide images (WSIs) plays a key role in cancer diagnosis and clinical practice. Due to the high resolution of the WSI and the unavailability of patch-level annotations, WSI classification is usually…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 Litao Yang , Deval Mehta , Sidong Liu , Dwarikanath Mahapatra , Antonio Di Ieva , Zongyuan Ge

The deployment of vision-language models (VLMs) in dermatology is hindered by the trilemma of high computational costs, extreme data scarcity, and the black-box nature of deep learning. To address these challenges, we present SkinCLIP-VL, a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Zhixiang Lu , Shijie Xu , Kaicheng Yan , Xuyue Cai , Chong Zhang , Yulong Li , Angelos Stefanidis , Anh Nguyen , Jionglong Su

While Large Language Models (LLMs) are emerging as a promising direction in computational pathology, the substantial computational cost of giga-pixel Whole Slide Images (WSIs) necessitates the use of Multi-Instance Learning (MIL) to enable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Zhenfeng Zhuang , Fangyu Zhou , Liansheng Wang

Supervised learning tasks such as cancer survival prediction from gigapixel whole slide images (WSIs) are a critical challenge in computational pathology that requires modeling complex features of the tumor microenvironment. These learning…

Image and Video Processing · Electrical Eng. & Systems 2022-11-22 Iain Carmichael , Andrew H. Song , Richard J. Chen , Drew F. K. Williamson , Tiffany Y. Chen , Faisal Mahmood

Preoperative and noninvasive prediction of the meningioma grade is important in clinical practice, as it directly influences the clinical decision making. What's more, brain invasion in meningioma (i.e., the presence of tumor tissue within…

Computer Vision and Pattern Recognition · Computer Science 2022-09-07 Tianling Liu , Wennan Liu , Lequan Yu , Liang Wan , Tong Han , Lei Zhu

Multiple Instance Learning (MIL) is the predominant framework for classifying gigapixel whole-slide images in computational pathology. MIL follows a sequence of 1) extracting patch features, 2) applying a linear layer to obtain…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Daniel Shao , Joel Runevic , Richard J. Chen , Drew F. K. Williamson , Ahrong Kim , Andrew H. Song , Faisal Mahmood

The identification of melanoma involves an integrated analysis of skin lesion images acquired using the clinical and dermoscopy modalities. Dermoscopic images provide a detailed view of the subsurface visual structures that supplement the…

Computer Vision and Pattern Recognition · Computer Science 2022-06-13 Xiaohang Fu , Lei Bi , Ashnil Kumar , Michael Fulham , Jinman Kim

Purpose Tumor-infiltrating lymphocytes (TILs) have significant prognostic values in cancers. However, very few automated, deep-learning-based TIL scoring algorithms have been developed for colorectal cancers (CRC). Methods We developed an…

Quantitative Methods · Quantitative Biology 2022-09-16 Anran Liu , Xingyu Li , Hongyi Wu , Bangwei Guo , Jitendra Jonnagaddala , Hong Zhang , Xu Steven Xu

Multiple-instance Learning (MIL) is commonly used to undertake computational pathology (CPath) tasks, and the use of multi-scale patches allows diverse features across scales to be learned. Previous studies using multi-scale features in…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Shuyang Wu , Yifu Qiu , Ines P. Nearchou , Sandrine Prost , Jonathan A Fallowfield , Hakan Bilen , Timothy J Kendall

The 7-point checklist (7PCL) is a widely used diagnostic tool in dermoscopy for identifying malignant melanoma by assigning point values to seven specific attributes. However, the traditional 7PCL is limited to distinguishing between…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Yuheng Wang , Tianze Yu , Jiayue Cai , Sunil Kalia , Harvey Lui , Z. Jane Wang , Tim K. Lee

Attention-based multiple instance learning (MIL) has emerged as a powerful framework for whole slide image (WSI) diagnosis, leveraging attention to aggregate instance-level features into bag-level predictions. Despite this success, we find…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Linfeng Ye , Shayan Mohajer Hamidi , Zhixiang Chi , Guang Li , Mert Pilanci , Takahiro Ogawa , Miki Haseyama , Konstantinos N. Plataniotis

Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervision is typically provided only at the bag level, hindering the integrated consideration of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Shuyang Wu , Yifu Qiu , Ines P. Nearchou , Sandrine Prost , Jonathan A. Fallowfield , Hideki Ueno , Hitoshi Tsuda , David J. Harrison , Hakan Bilen , Timothy J. Kendall

Multi-instance learning (MIL) is an effective paradigm for whole-slide pathological images (WSIs) classification to handle the gigapixel resolution and slide-level label. Prevailing MIL methods primarily focus on improving the feature…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Tiancheng Lin , Zhimiao Yu , Hongyu Hu , Yi Xu , Chang Wen Chen

Multiple instance learning (MIL) has enabled substantial progress in computational histopathology, where a large amount of patches from gigapixel whole slide images are aggregated into slide-level predictions. Heatmaps are widely used to…

Multiple Instance Learning (MIL) has been widely applied to medical imaging diagnosis, where bag labels are known and instance labels inside bags are unknown. Traditional MIL assumes that instances in each bag are independent samples from a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-19 Yunan Wu , Francisco M. Castro-Macías , Pablo Morales-Álvarez , Rafael Molina , Aggelos K. Katsaggelos

Multiple instance learning (MIL) is a supervised learning methodology that aims to allow models to learn instance class labels from bag class labels, where a bag is defined to contain multiple instances. MIL is gaining traction for learning…

Computer Vision and Pattern Recognition · Computer Science 2019-11-14 Samuel W. Remedios , Zihao Wu , Camilo Bermudez , Cailey I. Kerley , Snehashis Roy , Mayur B. Patel , John A. Butman , Bennett A. Landman , Dzung L. Pham

Automatic and precise medical image segmentation (MIS) is of vital importance for clinical diagnosis and analysis. Current MIS methods mainly rely on the convolutional neural network (CNN) or self-attention mechanism (Transformer) for…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Lanhu Wu , Miao Zhang , Yongri Piao , Zhenyan Yao , Weibing Sun , Feng Tian , Huchuan Lu