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Large Language Models (LLMs) applied to code-related applications have emerged as a prominent field, attracting significant interest from both academia and industry. However, as new and improved LLMs are developed, existing evaluation…

Software Engineering · Computer Science 2024-06-07 Naman Jain , King Han , Alex Gu , Wen-Ding Li , Fanjia Yan , Tianjun Zhang , Sida Wang , Armando Solar-Lezama , Koushik Sen , Ion Stoica

The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination,…

Artificial Intelligence · Computer Science 2026-02-12 Zhiling Yan , Dingjie Song , Zhe Fang , Yisheng Ji , Xiang Li , Quanzheng Li , Lichao Sun

Large language models (LLMs) have become important tools in solving biological problems, offering improvements in accuracy and adaptability over conventional methods. Several benchmarks have been proposed to evaluate the performance of…

We present a new approach for benchmarking Large Language Model (LLM) capabilities on research-level mathematics. Existing benchmarks largely rely on static, hand-curated sets of contest or textbook-style problems as proxies for…

Artificial Intelligence · Computer Science 2026-03-02 Antoine Peyronnet , Fabian Gloeckle , Amaury Hayat

Advanced Large Multimodal Models (LMMs) have demonstrated impressive performance in K-12 reasoning tasks, exhibiting great promise as intelligent tutors. Realizing this potential requires models to navigate real-world examinations…

Artificial Intelligence · Computer Science 2026-05-27 Xiaohan Wang , Mingze Yin , Yilin Zhao , Gang Liu , Dian Li

Protein-specific large language models (Protein LLMs) are revolutionizing protein science by enabling more efficient protein structure prediction, function annotation, and design. While existing surveys focus on specific aspects or…

The parallels between protein sequences and natural language in their sequential structures have inspired the application of large language models (LLMs) to protein understanding. Despite the success of LLMs in NLP, their effectiveness in…

Quantitative Methods · Quantitative Biology 2024-07-09 Yiqing Shen , Zan Chen , Michail Mamalakis , Luhan He , Haiyang Xia , Tianbin Li , Yanzhou Su , Junjun He , Yu Guang Wang

There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and…

Test set contamination, wherein test data from a benchmark ends up in a newer model's training set, is a well-documented obstacle for fair LLM evaluation and can quickly render benchmarks obsolete. To mitigate this, many recent benchmarks…

Large language models (LLMs) have garnered considerable attention for their proficiency in tackling intricate tasks, particularly leveraging their capacities for zero-shot and in-context learning. However, their utility has been…

Biomolecules · Quantitative Biology 2024-05-14 Yiqing Shen , Outongyi Lv , Houying Zhu , Yu Guang Wang

Large Language Models (LLMs) hold significant potential for advancing fact-checking by leveraging their capabilities in reasoning, evidence retrieval, and explanation generation. However, existing benchmarks fail to comprehensively evaluate…

Computation and Language · Computer Science 2025-06-17 Shuo Yang , Yuqin Dai , Guoqing Wang , Xinran Zheng , Jinfeng Xu , Jinze Li , Zhenzhe Ying , Weiqiang Wang , Edith C. H. Ngai

This study investigates the current landscape and future directions of protein foundation model research. While recent advancements have transformed protein science and engineering, the field lacks a comprehensive benchmark for fair…

Biomolecules · Quantitative Biology 2025-06-19 Zhangyang Gao , Hao Wang , Cheng Tan , Chenrui Xu , Mengdi Liu , Bozhen Hu , Linlin Chao , Xiaoming Zhang , Stan Z. Li

Mathematical reasoning is a hallmark of human intelligence, and whether large language models (LLMs) can meaningfully perform it remains a central question in artificial intelligence and cognitive science. As LLMs are increasingly…

Computation and Language · Computer Science 2026-04-03 Linyang He , Qiyao Yu , Hanze Dong , Baohao Liao , Xinxing Xu , Micah Goldblum , Jiang Bian , Nima Mesgarani

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Multimodal Large Language models (MLLMs) have shown promise in web-related tasks, but evaluating their performance in the web domain remains a challenge due to the lack of comprehensive benchmarks. Existing benchmarks are either designed…

Computation and Language · Computer Science 2024-04-10 Junpeng Liu , Yifan Song , Bill Yuchen Lin , Wai Lam , Graham Neubig , Yuanzhi Li , Xiang Yue

Large Multimodal Models (LMMs) exhibit major shortfalls when interpreting images and, by some measures, have poorer spatial cognition than small children or animals. Despite this, they attain high scores on many popular visual benchmarks,…

Effective processing, interpretation, and management of sensor data have emerged as a critical component of cyber-physical systems. Traditionally, processing sensor data requires profound theoretical knowledge and proficiency in…

Artificial Intelligence · Computer Science 2025-04-01 Pengrui Quan , Xiaomin Ouyang , Jeya Vikranth Jeyakumar , Ziqi Wang , Yang Xing , Mani Srivastava

Most of the existing Large Language Model (LLM) benchmarks on scientific problem reasoning focus on problems grounded in high-school subjects and are confined to elementary algebraic operations. To systematically examine the reasoning…

Computation and Language · Computer Science 2024-07-01 Xiaoxuan Wang , Ziniu Hu , Pan Lu , Yanqiao Zhu , Jieyu Zhang , Satyen Subramaniam , Arjun R. Loomba , Shichang Zhang , Yizhou Sun , Wei Wang

While Large Language Models (LLMs) excel on standardized medical exams, high scores often fail to translate to high-quality responses for real-world medical queries. Current evaluations rely heavily on multiple-choice questions, failing to…

Can the rapid advances in code generation, function calling, and data analysis using large language models (LLMs) help automate the search and verification of hypotheses purely from a set of provided datasets? To evaluate this question, we…

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