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Drug discovery is crucial for identifying candidate drugs for various diseases.However, its low success rate often results in a scarcity of annotations, posing a few-shot learning problem. Existing methods primarily focus on single-scale…

Machine Learning · Computer Science 2025-02-19 Ruifeng Li , Mingqian Li , Wei Liu , Yuhua Zhou , Xiangxin Zhou , Yuan Yao , Qiang Zhang , Hongyang Chen

Data similarity is a key concept in many data-driven applications. Many algorithms are sensitive to similarity measures. To tackle this fundamental problem, automatically learning of similarity information from data via self-expression has…

Machine Learning · Computer Science 2019-03-12 Zhao Kang , Yiwei Lu , Yuanzhang Su , Changsheng Li , Zenglin Xu

We consider methods for transporting a prediction model and assessing its performance for use in a new target population, when outcome and covariate information for model development is available from a simple random sample from the source…

Applications · Statistics 2021-04-15 Jon A. Steingrimsson , Constantine Gatsonis , Issa J. Dahabreh

Deep learning systems are typically designed to perform for a wide range of test inputs. For example, deep learning systems in autonomous cars are supposed to deal with traffic situations for which they were not specifically trained. In…

Machine Learning · Computer Science 2021-06-01 Shih-Ting Huang , Johannes Lederer

Neural networks often learn spurious correlations when exposed to biased training data, leading to poor performance on out-of-distribution data. A biased dataset can be divided, according to biased features, into bias-aligned samples (i.e.,…

Machine Learning · Computer Science 2023-08-17 Rui Hu , Yahan Tu , Jitao Sang

Current machine learning has made great progress on computer vision and many other fields attributed to the large amount of high-quality training samples, while it does not work very well on genomic data analysis, since they are notoriously…

Machine Learning · Computer Science 2020-09-04 Ziyi Yang , Jun Shu , Yong Liang , Deyu Meng , Zongben Xu

Medical events of interest, such as mortality, often happen at a low rate in electronic medical records, as most admitted patients survive. Training models with this imbalance rate (class density discrepancy) may lead to suboptimal…

Machine Learning · Computer Science 2022-08-02 Zepeng Huo , Xiaoning Qian , Shuai Huang , Zhangyang Wang , Bobak J. Mortazavi

Flow matching has emerged as a powerful generative framework, with recent few-step methods achieving remarkable inference acceleration. However, we identify a critical yet overlooked limitation: these models suffer from severe diversity…

Machine Learning · Computer Science 2026-04-15 Yexiong Lin , Jia Shi , Shanshan Ye , Wanyu Wang , Yu Yao , Tongliang Liu

Data clustering, the task of grouping observations according to their similarity, is a key component of unsupervised learning -- with real world applications in diverse fields such as biology, medicine, and social science. Often in these…

Machine Learning · Computer Science 2023-09-20 Anne Sophie Riis Damstrup , Sofie Tosti Madsen , Michele Coscia

Machine learning models, and deep neural networks in particular, are increasingly deployed in risk-sensitive domains such as healthcare, environmental forecasting, and finance, where reliable quantification of predictive uncertainty is…

Machine Learning · Computer Science 2026-04-07 Asena Karolin Özdemir , Lars H. Heyen , Arvid Weyrauch , Achim Streit , Markus Götz , Charlotte Debus

We provide a general framework for learning diffusion bridges that transport prior to target distributions. It includes existing diffusion models for generative modeling, but also underdamped versions with degenerate diffusion matrices,…

Machine Learning · Computer Science 2025-08-14 Denis Blessing , Julius Berner , Lorenz Richter , Gerhard Neumann

Machine learning holds tremendous promise for transforming the fundamental practice of scientific discovery by virtue of its data-driven nature. With the ever-increasing stream of research data collection, it would be appealing to…

Machine Learning · Computer Science 2024-03-06 Jianan Fan , Dongnan Liu , Hang Chang , Heng Huang , Mei Chen , Weidong Cai

Voice imitation aims to transform source speech to match a reference speaker's timbre and speaking style while preserving linguistic content. A straightforward approach is to train on triplets of (source, reference, target), where source…

Sound · Computer Science 2026-04-21 Tao Feng , Yuxiang Wang , Yuancheng Wang , Xueyao Zhang , Dekun Chen , Chaoren Wang , Xun Guan , Zhizheng Wu

Model reuse offers a solution to the challenges of segmentation in biomedical imaging, where high data annotation costs remain a major bottleneck for deep learning. However, although many pretrained models are released through challenges,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Joshua Talks , Kevin Marchesini , Luca Lumetti , Federico Bolelli , Anna Kreshuk

The application of transfer learning, leveraging knowledge from source domains to enhance model performance in a target domain, has significantly grown, supporting diverse real-world applications. Its success often relies on shared…

Machine Learning · Computer Science 2024-07-19 Runxue Bao , Yiming Sun , Yuhe Gao , Jindong Wang , Qiang Yang , Zhi-Hong Mao , Ye Ye

Supervised learning under measurement constraints is a common challenge in statistical and machine learning. In many applications, despite extensive design points, acquiring responses for all points is often impractical due to resource…

Methodology · Statistics 2025-03-19 Lin Wang

In clinical settings, we often face the challenge of building prediction models based on small observational data sets. For example, such a data set might be from a medical center in a multi-center study. Differences between centers might…

Peptide identification in mass spectrometry-based proteomics is crucial for understanding protein function and dynamics. Traditional database search methods, though widely used, rely on heuristic scoring functions and statistical…

Quantitative Methods · Quantitative Biology 2024-05-13 Yonghan Yu , Ming Li

The successful application of deep learning to many visual recognition tasks relies heavily on the availability of a large amount of labeled data which is usually expensive to obtain. The few-shot learning problem has attracted increasing…

Machine Learning · Computer Science 2020-03-11 Zhongjie Yu , Lin Chen , Zhongwei Cheng , Jiebo Luo

We consider a human-assisted autonomy sensor fusion for dynamic target localization in a Bayesian framework. Autonomous sensor-based tracking systems can suffer from observability and target detection failure. Humans possess valuable…

Robotics · Computer Science 2024-10-08 Min-Won Seo , Solmaz S. Kia