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Recent progress in Large Language Models (LLMs) has drawn attention to their potential for accelerating drug discovery. However, a central problem remains: translating theoretical ideas into robust implementations in the highly specialized…

Machine Learning · Computer Science 2025-03-06 Sizhe Liu , Yizhou Lu , Siyu Chen , Xiyang Hu , Jieyu Zhao , Yingzhou Lu , Yue Zhao

Large Language Model (LLM)-based multi-agent systems rely on optimized collaboration topologies to balance performance and communication costs. However, current methods struggle with the inherent stability-extensibility trade-off and often…

Multiagent Systems · Computer Science 2026-05-27 Xinkui Zhao , Sai Liu , Yifan Zhang , Qingyu Ma , Zewen Lin , Naibo Wang , Guanjie Cheng , Chang Liu , Yueshen Xu

Research interest in autonomous agents is on the rise as an emerging topic. The notable achievements of Large Language Models (LLMs) have demonstrated the considerable potential to attain human-like intelligence in autonomous agents.…

Multiagent Systems · Computer Science 2025-01-30 Hung Du , Srikanth Thudumu , Rajesh Vasa , Kon Mouzakis

Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic…

Artificial Intelligence · Computer Science 2025-10-14 Hongjie Zheng , Zesheng Shi , Ping Yi

We present Verified Multi-Agent Orchestration (VMAO), a framework that coordinates specialized LLM-based agents through a verification-driven iterative loop. Given a complex query, our system decomposes it into a directed acyclic graph…

Artificial Intelligence · Computer Science 2026-03-17 Xing Zhang , Yanwei Cui , Guanghui Wang , Wei Qiu , Ziyuan Li , Fangwei Han , Yajing Huang , Hengzhi Qiu , Bing Zhu , Peiyang He

Large Language Models (LLMs) often struggle with structural ambiguity in optimization problems, where a single problem admits multiple related but conflicting modeling paradigms, hindering effective solution generation. To address this, we…

Computation and Language · Computer Science 2026-04-23 Xinyu Zhang , Yuchen Wan , Boxuan Zhang , Zesheng Yang , Lingling Zhang , Bifan Wei , Jun Liu

Decentralized Autonomous Organizations (DAOs), based on block-chain systems such as Ethereum, are emerging governance protocols that enable decentralized community management without a central authority. For instance, UniswapDAO allows…

Cryptography and Security · Computer Science 2024-10-30 Neil Shah

This research article presents a novel architecture to empower multi-agent economies by addressing two critical limitations of the emerging Agent2Agent (A2A) communication protocol: decentralized agent discoverability and agent-to-agent…

Multiagent Systems · Computer Science 2026-05-06 Awid Vaziry , Sandro Rodriguez Garzon , Axel Küpper

Recently, a new generation of P2P systems capable of addressing data integrity and authenticity has emerged for the development of new applications for a "more" decentralized Internet, i.e., Distributed Ledger Technologies (DLT) and…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-09-13 Mirko Zichichi , Luca Serena , Stefano Ferretti , Gabriele D'Angelo

Blockchains and distributed ledger technologies allow the operation of manifold decentralised applications (dApps). Such applications are based on smart contracts, a programmable abstraction that is executed in a decentralised manner. To…

Software Engineering · Computer Science 2026-05-22 Fabian Stiehle , Kirill Inozemtsev , Ingo Weber

Agentic AI rivals human capabilities across a wide range of domains. Looking ahead, it is foreseeable that AI agents will autonomously handle complex workflows and interactions. Early prototypes of this paradigm are emerging, e.g., OpenClaw…

Large language model (LLM) agents increasingly coordinate in multi-agent systems, yet we lack an understanding of where and why cooperation failures may arise. In many real-world coordination problems, from knowledge sharing in…

Multiagent Systems · Computer Science 2026-04-10 Advait Yadav , Sid Black , Oliver Sourbut

Blockchain and smart contracts have garnered significant interest in recent years as the foundation of a decentralized, trustless digital ecosystem, thereby eliminating the need for traditional centralized authorities. Despite their central…

Cryptography and Security · Computer Science 2025-09-10 Nicolò Romandini , Carlo Mazzocca , Kai Otsuki , Rebecca Montanari

Autonomous Driving Systems (ADSs) are revolutionizing transportation by reducing human intervention, improving operational efficiency, and enhancing safety. Large Language Models (LLMs) have been integrated into ADSs to support high-level…

Multiagent Systems · Computer Science 2025-10-15 Yaozu Wu , Dongyuan Li , Yankai Chen , Renhe Jiang , Henry Peng Zou , Wei-Chieh Huang , Yangning Li , Liancheng Fang , Zhen Wang , Philip S. Yu

Large language models (LLMs) deployed as agents introduce significant safety risks in clinical settings due to their potential for error and single points of failure. We introduce Tiered Agentic Oversight (TAO), a hierarchical multi-agent…

Decentralized Autonomous Organizations (DAOs), utilizing blockchain technology to enable collective governance, are a promising innovation. This research addresses the ongoing query in blockchain governance: How can DAOs optimize human…

General Economics · Economics 2025-08-11 Yulin Liu , Luyao Zhang

Recent studies show that collaborating multiple large language model (LLM) powered agents is a promising way for task solving. However, current approaches are constrained by using a fixed number of agents and static communication…

Computation and Language · Computer Science 2024-11-18 Zijun Liu , Yanzhe Zhang , Peng Li , Yang Liu , Diyi Yang

This chapter explores how Decentralized Autonomous Organizations (DAOs), a novel institutional form based on blockchain technology, challenge traditional centralized governance structures. DAOs govern projects ranging from finance to…

Computers and Society · Computer Science 2025-11-13 Stefano Balietti , Pietro Saggese , Stefan Kitzler , Bernhard Haslhofer

In order to collaborate efficiently with unknown partners in cooperative control settings, adaptation of the partners based on online experience is required. The rather general and widely applicable control setting, where each cooperation…

Multiagent Systems · Computer Science 2019-10-30 Florian Köpf , Samuel Tesfazgi , Michael Flad , Sören Hohmann

Large language model based multi-agent systems have demonstrated significant potential in social simulation and complex task resolution domains. However, current frameworks face critical challenges in system architecture design,…

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