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Inspection of tissues using a light microscope is the primary method of diagnosing many diseases, notably cancer. Highly multiplexed tissue imaging builds on this foundation, enabling the collection of up to 60 channels of molecular…

We review some recent learning approaches in variational imaging, based on bilevel optimisation, and emphasize the importance of their treatment in function space. The paper covers both analytical and numerical techniques. Analytically, we…

Optimization and Control · Mathematics 2016-08-08 Luca Calatroni , Cao Chung , Juan Carlos De Los Reyes , Carola-Bibiane Schönlieb , Tuomo Valkonen

Multiplexed tissue imaging measures dozens of protein markers per cell, yet most deep learning models still apply early channel fusion, assuming shared structure across markers. We investigate whether preserving marker independence,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-18 Simon Gutwein , Arthur Longuefosse , Jun Seita , Sabine Taschner-Mandl , Roxane Licandro

Engineering simple, artificial models of living cells allows synthetic biologists to study cellular functions under well-controlled conditions. Reconstituting multicellular behaviors with synthetic cell-mimics is still a challenge because…

Biomolecules · Quantitative Biology 2021-04-29 Imre Banlaki , Francois-Xavier Lehr , Henrike Niederholtmeyer

Recent fMRI-to-image approaches mainly focused on associating fMRI signals with specific conditions of pre-trained diffusion models. These approaches, while producing high-quality images, capture only a limited aspect of the complex…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Jingyang Huo , Yikai Wang , Xuelin Qian , Yun Wang , Chong Li , Jianfeng Feng , Yanwei Fu

Every year millions of people die due to disease of Cancer. Due to its invasive nature it is very complex to cure even in primary stages. Hence, only method to survive this disease completely is via forecasting by analyzing the early…

Computer Vision and Pattern Recognition · Computer Science 2018-08-24 Shivam Singh , Stuti Pathak

Different cell types aggregate and sort into hierarchical architectures during the formation of animal tissues. The resulting spatial organization depends (in part) on the strength of adhesion of one cell type to itself relative to other…

Quantitative Methods · Quantitative Biology 2023-08-02 Dhananjay Bhaskar , William Y. Zhang , Alexandria Volkening , Björn Sandstede , Ian Y. Wong

Multimode fibres (MMF) are remarkable high-capacity information channels owing to the large number of transmitting fibre modes, and have recently attracted significant renewed interest in applications such as optical communication, imaging,…

Optics · Physics 2018-08-27 Pengfei Fan , Tianrui Zhao , Lei Su

Accurate cell counting is essential in various biomedical research and clinical applications, including cancer diagnosis, stem cell research, and immunology. Manual counting is labor-intensive and error-prone, motivating automation through…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Abdurahman Ali Mohammed , Catherine Fonder , Ying Wei , Wallapak Tavanapong , Donald S Sakaguchi , Qi Li , Surya K. Mallapragada

Traditionally, diagnosis and treatment of fungal infections in humans depend heavily on face-to-face consultations or examinations made by specialized laboratory scientists known as mycologists. In many cases, such as the recent…

Image and Video Processing · Electrical Eng. & Systems 2021-09-16 Camilo Javier Pineda Sopo , Farshid Hajati , Soheila Gheisari

Pathology image segmentation across multiple centers encounters significant challenges due to diverse sources of heterogeneity including imaging modalities, organs, and scanning equipment, whose variability brings representation bias and…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Yuan Zhang , Feng Chen , Yaolei Qi , Guanyu Yang , Huazhu Fu

Masked Image Modeling (MIM) has garnered significant attention in self-supervised learning, thanks to its impressive capacity to learn scalable visual representations tailored for downstream tasks. However, images inherently contain…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Wenzhao Xiang , Chang Liu , Hongyang Yu , Xilin Chen

Identifying cell types and subtypes in routine histopathology is fundamental for understanding disease. Existing tile-based models capture nuclear detail but miss the broader tissue context that influences cell identity. Current human…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Yinuo Xu , Yan Cui , Mingyao Li , Zhi Huang

Medical Informatics and the application of modern signal processing in the assistance of the diagnostic process in medical imaging is one of the more recent and active research areas today. This thesis addresses a variety of issues related…

Computer Vision and Pattern Recognition · Computer Science 2009-10-20 Harris Georgiou

Diffusion MRI (dMRI) is the primary imaging modality used to study brain microstructure in vivo. Reliable and computationally efficient parameter inference for common dMRI biophysical models is a challenging inverse problem, due to factors…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 William Consagra , Lipeng Ning , Yogesh Rathi

Foundation models are widely employed in medical image analysis, due to their high adaptability and generalizability for downstream tasks. With the increasing number of foundation models being released, model selection has become an…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Fuping Wu , Bartlomiej W. Papiez

Rapid developments of AI tools are expected to offer unprecedented assistance to the research of natural science including chemistry. However, neither existing unimodal task-specific specialist models nor emerging general large multimodal…

Machine Learning · Computer Science 2025-01-03 Zihan Zhao , Bo Chen , Jingpiao Li , Lu Chen , Liyang Wen , Pengyu Wang , Zichen Zhu , Danyang Zhang , Ziping Wan , Yansi Li , Zhongyang Dai , Xin Chen , Kai Yu

Raman spectroscopy's capability to provide meaningful composition predictions is heavily reliant on a pre-processing step to remove insignificant spectral variation. This is crucial in biofluid analysis. Widespread adoption of diagnostics…

Signal Processing · Electrical Eng. & Systems 2019-04-05 Emily E Storey , Amr S. Helmy

Learned data models based on sparsity are widely used in signal processing and imaging applications. A variety of methods for learning synthesis dictionaries, sparsifying transforms, etc., have been proposed in recent years, often imposing…

Machine Learning · Computer Science 2018-10-22 Saiprasad Ravishankar , Brendt Wohlberg

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

Computer Vision and Pattern Recognition · Computer Science 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot
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