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Uncertainty estimation in deep learning has become a leading research field in medical image analysis due to the need for safe utilisation of AI algorithms in clinical practice. Most approaches for uncertainty estimation require sampling…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 Kaisar Kushibar , Víctor Manuel Campello , Lidia Garrucho Moras , Akis Linardos , Petia Radeva , Karim Lekadir

Uncertainty estimation, which provides a means of building explainable neural networks for medical imaging applications, have mostly been studied for single deep learning models that focus on a specific task. In this paper, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2023-10-02 Leonhard F. Feiner , Martin J. Menten , Kerstin Hammernik , Paul Hager , Wenqi Huang , Daniel Rueckert , Rickmer F. Braren , Georgios Kaissis

Development of an accurate, flexible, and numerically efficient uncertainty quantification (UQ) method is one of fundamental challenges in machine learning. Previously, a UQ method called DISCO Nets has been proposed (Bouchacourt et al.,…

Machine Learning · Computer Science 2023-07-06 Takuya Kanazawa , Chetan Gupta

Quantifying uncertainty is important for actionable predictions in real-world applications. A crucial part of predictive uncertainty quantification is the estimation of epistemic uncertainty, which is defined as an integral of the product…

Machine Learning · Computer Science 2023-10-25 Kajetan Schweighofer , Lukas Aichberger , Mykyta Ielanskyi , Günter Klambauer , Sepp Hochreiter

As large language models (LLMs) are increasingly integrated into high-stakes decision-making, the ability to reliably quantify uncertainty has become a critical requirement for safety and trust. However, current uncertainty quantification…

Artificial Intelligence · Computer Science 2026-05-28 Seongjun Lee , Suwan Yoon , Changhee Lee

Uncertainty quantification (UQ) in scientific machine learning is increasingly critical as neural networks are widely adopted to tackle complex problems across diverse scientific disciplines. For physics-informed neural networks (PINNs), a…

Machine Learning · Statistics 2025-10-20 Frank Shih , Zhenghao Jiang , Faming Liang

Deep learning models for semantic segmentation are prone to poor performance in real-world applications due to the highly challenging nature of the task. Model uncertainty quantification (UQ) is one way to address this issue of lack of…

Computer Vision and Pattern Recognition · Computer Science 2022-11-04 Rishabh Singh , Jose C. Principe

Due to the cross-domain distribution shift aroused from diverse medical imaging systems, many deep learning segmentation methods fail to perform well on unseen data, which limits their real-world applicability. Recent works have shown the…

Computer Vision and Pattern Recognition · Computer Science 2023-03-06 Shangqi Gao , Hangqi Zhou , Yibo Gao , Xiahai Zhuang

Statistical shape modeling (SSM) has recently taken advantage of advances in deep learning to alleviate the need for a time-consuming and expert-driven workflow of anatomy segmentation, shape registration, and the optimization of…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Jadie Adams , Riddhish Bhalodia , Shireen Elhabian

With the widespread success of deep neural networks in science and technology, it is becoming increasingly important to quantify the uncertainty of the predictions produced by deep learning. In this paper, we introduce a new method that…

Machine Learning · Computer Science 2019-08-15 Qingyang Wu , He Li , Lexin Li , Zhou Yu

Neural networks (NNs) are currently changing the computational paradigm on how to combine data with mathematical laws in physics and engineering in a profound way, tackling challenging inverse and ill-posed problems not solvable with…

Machine Learning · Computer Science 2023-02-08 Apostolos F Psaros , Xuhui Meng , Zongren Zou , Ling Guo , George Em Karniadakis

Accurate uncertainty estimation is a critical need for the medical imaging community. A variety of methods have been proposed, all direct extensions of classification uncertainty estimations techniques. The independent pixel-wise…

Image and Video Processing · Electrical Eng. & Systems 2022-06-16 Thierry Judge , Olivier Bernard , Mihaela Porumb , Agis Chartsias , Arian Beqiri , Pierre-Marc Jodoin

Image-to-image translation plays a vital role in tackling various medical imaging tasks such as attenuation correction, motion correction, undersampled reconstruction, and denoising. Generative adversarial networks have been shown to…

Computer Vision and Pattern Recognition · Computer Science 2021-07-05 Uddeshya Upadhyay , Yanbei Chen , Tobias Hepp , Sergios Gatidis , Zeynep Akata

Medical image segmentation is critical for disease diagnosis and treatment assessment. However, concerns regarding the reliability of segmentation regions persist among clinicians, mainly attributed to the absence of confidence assessment,…

Image and Video Processing · Electrical Eng. & Systems 2025-09-12 Ke Zou , Yidi Chen , Ling Huang , Xuedong Yuan , Xiaojing Shen , Meng Wang , Rick Siow Mong Goh , Yong Liu , Huazhu Fu

Deep learning based methods for automatic organ segmentation have shown promise in aiding diagnosis and treatment planning. However, quantifying and understanding the uncertainty associated with model predictions is crucial in critical…

Image and Video Processing · Electrical Eng. & Systems 2023-08-16 Jadie Adams , Shireen Y. Elhabian

In this work, we examine the effectiveness of an uncertainty quantification framework known as Evidential Deep Learning applied in the context of biomedical image segmentation. This class of models involves assigning Dirichlet distributions…

Image and Video Processing · Electrical Eng. & Systems 2025-04-24 Hai Siong Tan , Kuancheng Wang , Rafe Mcbeth

The healthcare industry has been revolutionized by the convergence of Artificial Intelligence of Medical Things (AIoMT), allowing advanced data-driven solutions to improve healthcare systems. With the increasing complexity of Artificial…

Computer Vision and Pattern Recognition · Computer Science 2024-03-08 Al Amin , Kamrul Hasan , Saleh Zein-Sabatto , Deo Chimba , Imtiaz Ahmed , Tariqul Islam

In this paper, we approach the problem of uncertainty quantification in deep learning through a predictive framework, which captures uncertainty in model parameters by specifying our assumptions about the predictive distribution of unseen…

Machine Learning · Statistics 2024-03-20 Luhuan Wu , Sinead Williamson

Artificial Intelligence in Medicine has made significant progress with emerging applications in medical imaging, patient care, and other areas. While these applications have proven successful in retrospective studies, very few of them were…

Artificial Intelligence · Computer Science 2023-08-11 Nicoletta Prentzas , Antonis Kakas , Constantinos S. Pattichis