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Recently, a new testing approach for response-adaptive clinical trials was proposed based on the allocation probabilities (AP) rather than the outcome data. While original work on the AP test focused on binary and normal endpoints and…

Methodology · Statistics 2026-05-11 Stina Zetterstrom , David S. Robertson , Thomas Jaki , Sofía S. Villar

Traditional hypothesis tests for differences between binomial proportions are at risk of being too liberal (Wald test) or overly conservative (Fisher's exact test). This problem is exacerbated in small samples. Regulators favour exact…

Methodology · Statistics 2025-07-31 Stef Baas , Yaron Racah , Elad Berkman , Sofia S. Villar

A central goal in designing clinical trials is to find the test that maximizes power (or equivalently minimizes required sample size) for finding a false null hypothesis subject to the constraint of type I error. When there is more than one…

Methodology · Statistics 2022-09-21 Ruth Heller , Abba Krieger , Saharon Rosset

Genetic investigations often involve the testing of vast numbers of related hypotheses simultaneously. To control the overall error rate, a substantial penalty is required, making it difficult to detect signals of moderate strength. To…

Methodology · Statistics 2010-10-25 Kathryn Roeder , Larry Wasserman

The power of multiple testing procedures can be increased by using weighted p-values (Genovese, Roeder and Wasserman 2005). We derive the optimal weights and we show that the power is remarkably robust to misspecification of these weights.…

Statistics Theory · Mathematics 2007-06-13 Larry Wasserman , Kathryn Roeder

This paper studies optimal hypothesis testing for nonregular econometric models with parameter-dependent support. We consider both one-sided and two-sided hypothesis testing and develop asymptotically uniformly most powerful tests based on…

Statistics Theory · Mathematics 2025-10-07 Yuya Shimizu , Taisuke Otsu

When the experimental objective is expressed by a set of estimable functions, and any eigenvalue-based optimality criterion is selected, we prove the equivalence of the recently introduced weighted optimality and the 'standard' optimality…

Statistics Theory · Mathematics 2016-10-21 Samuel Rosa

Motivated by the widespread adoption of large-scale A/B testing in industry, we propose a new experimentation framework for the setting where potential experiments are abundant (i.e., many hypotheses are available to test), and observations…

Machine Learning · Statistics 2018-05-31 Sven Schmit , Virag Shah , Ramesh Johari

The main purpose of this paper is to provide an asymptotically optimal test. The proposed statistic is of Neyman-Pearson-type when the parameters are estimated with a particular kind of estimators. It is shown that the proposed estimators…

Applications · Statistics 2011-10-04 Tewfik Lounis

This paper proposes a max-test for testing (possibly infinitely) many zero parameter restrictions in an extremum estimation framework. The test statistic is formed by estimating key parameters one at a time based on many empirical loss…

Statistics Theory · Mathematics 2022-04-12 Jonathan B. Hill

We consider tests of hypotheses when the parameters are not identifiable under the null in semiparametric models, where regularity conditions for profile likelihood theory fail. Exponential average tests based on integrated profile…

Statistics Theory · Mathematics 2009-08-25 Rui Song , Michael R. Kosorok , Jason P. Fine

In confirmatory clinical trials with small sample sizes, hypothesis tests based on asymptotic distributions are often not valid and exact non-parametric procedures are applied instead. However, the latter are based on discrete test…

Methodology · Statistics 2018-02-22 Robin Ristl , Dong Xi , Ekkehard Glimm , Martin Posch

Algorithm evaluation and comparison are fundamental questions in machine learning and statistics -- how well does an algorithm perform at a given modeling task, and which algorithm performs best? Many methods have been developed to assess…

Statistics Theory · Mathematics 2025-11-25 Yuetian Luo , Rina Foygel Barber

The integration of renewables into electrical grids calls for the development of tailored control schemes which in turn require reliable grid models. In many cases, the grid topology is known but the actual parameters are not exactly known.…

Systems and Control · Electrical Eng. & Systems 2020-05-12 Xu Du , Alexander Engelmann , Yuning Jiang , Timm Faulwasser , Boris Houska

Experimental comparisons of performance represent an important aspect of research on optimization algorithms. In this work we present a methodology for defining the required sample sizes for designing experiments with desired statistical…

Neural and Evolutionary Computing · Computer Science 2018-10-16 Felipe Campelo , Fernanda Takahashi

We consider the group testing problem, in the case where the items are defective independently but with non-constant probability. We introduce and analyse an algorithm to solve this problem by grouping items together appropriately. We give…

Information Theory · Computer Science 2015-02-04 Tom Kealy , Oliver Johnson , Robert Piechocki

A problem faced by many instructors is that of designing exams that accurately assess the abilities of the students. Typically these exams are prepared several days in advance, and generic question scores are used based on rough…

Computers and Society · Computer Science 2018-11-07 Sam Ganzfried , Farzana Yusuf

We consider the problem of hypothesis testing for discrete distributions. In the standard model, where we have sample access to an underlying distribution $p$, extensive research has established optimal bounds for uniformity testing,…

Machine Learning · Computer Science 2024-12-03 Maryam Aliakbarpour , Piotr Indyk , Ronitt Rubinfeld , Sandeep Silwal

We study the problem of determining exactly the number of defective items in an adaptive Group testing by using a minimum number of tests. We improve the existing algorithm and prove a lower bound that shows that the number of tests in our…

Information Theory · Computer Science 2020-01-03 Nader H. Bshouty , Catherine A. Haddad-Zaknoon , Raghd Boulos , Foad Moalem , Jalal Nada , Elias Noufi , Yara Zaknoon

The task of estimating a matrix given a sample of observed entries is known as the \emph{matrix completion problem}. Most works on matrix completion have focused on recovering an unknown real-valued low-rank matrix from a random sample of…

Statistics Theory · Mathematics 2014-08-27 Olga Klopp , Jean Lafond , Eric Moulines , Joseph Salmon
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