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Accurately predicting early recurrence in brain tumor patients following surgical resection remains a clinical challenge. This study proposes a multi-modal machine learning framework that integrates structural MRI features with clinical…
Breast cancer is one of the leading causes of death for women worldwide. Early screening is essential for early identification, but the chance of survival declines as the cancer progresses into advanced stages. For this study, the most…
The level of tumour-infiltrating lymphocytes (TILs) is a prognostic factor for patients with (triple-negative) breast cancer (BC). Computational TIL assessment (CTA) has the potential to assist pathologists in this labour-intensive task,…
Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…
Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…
Due to the lack of fine-grained annotation guidance, current Multiple Instance Learning (MIL) struggles to establish a robust causal relationship between Whole Slide Image (WSI) diagnosis and evidence sub-images, just like fully supervised…
Multiple instance learning (MIL) is a powerful approach to classify whole slide images (WSIs) for diagnostic pathology. A fundamental challenge of MIL on WSI classification is to discover the \textit{critical instances} that trigger the bag…
In histopathology, intelligent diagnosis of Whole Slide Images (WSIs) is essential for automating and objectifying diagnoses, reducing the workload of pathologists. However, diagnostic models often face the challenge of forgetting…
Convolutional neural networks can be trained to perform histology slide classification using weak annotations with multiple instance learning (MIL). However, given the paucity of labeled histology data, direct application of MIL can easily…
Breast cancer is the most prevalent cancer in women worldwide. Histopathology image analysis serves as the gold standard for cancer diagnosis. In this regard, whole-slide imaging (WSI), a revolutionary technology in digital pathology,…
Breast cancer has the highest incidence and second highest mortality rate for women in the US. Our study aims to utilize deep learning for benign/malignant classification of mammogram tumors using a subset of cases from the Digital Database…
Treatment selection in breast cancer is guided by molecular subtypes and clinical characteristics. However, current tools including genomic assays lack the accuracy required for optimal clinical decision-making. We developed a novel…
Breast cancer is a major concern for women's health globally, with axillary lymph node (ALN) metastasis identification being critical for prognosis evaluation and treatment guidance. This paper presents a deep learning (DL) classification…
The International Symposium on Biomedical Imaging (ISBI) held a grand challenge to evaluate computational systems for the automated detection of metastatic breast cancer in whole slide images of sentinel lymph node biopsies. Our team won…
Breast cancer is the second most common malignancy among women and has become a major public health problem in current society. Traditional breast cancer identification requires experienced pathologists to carefully read the breast slice,…
In this work, we present a deep learning framework for multi-class breast cancer image classification as our submission to the International Conference on Image Analysis and Recognition (ICIAR) 2018 Grand Challenge on BreAst Cancer…
Precise breast cancer classification on histopathological images has the potential to greatly improve the diagnosis and patient outcome in oncology. The data imbalance problem largely stems from the inherent imbalance within medical image…
We propose a Deep learning-based weak label learning method for analyzing whole slide images (WSIs) of Hematoxylin and Eosin (H&E) stained tumor tissue not requiring pixel-level or tile-level annotations using Self-supervised pre-training…
Prognostic information at diagnosis has important implications for cancer treatment and monitoring. Although cancer staging, histopathological assessment, molecular features, and clinical variables can provide useful prognostic insights,…
In many histopathology tasks, sample classification depends on morphological details in tissue or single cells that are only visible at the highest magnification. For a pathologist, this implies tedious zooming in and out, while for a…