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Understanding the shell rheology of ultrasound contrast agent microbubbles is vital for anticipating their bioeffects in clinical practice. Past studies using sophisticated acoustic and optical techniques have made enormous progress in this…
The role and importance of mechanical properties of cells and tissues in cellular function, development as well as disease has widely been acknowledged, however standard techniques currently used to assess them exhibit intrinsic…
The rheology of phase-separated condensates plays a central role in applications spanning advanced materials design and cellular processes, yet quantitative characterization of their viscoelasticity remains challenging due to the…
Recent technological advances in cutting-edge ultrasensitive fluorescence microscopy have allowed single-molecule imaging experiments in living cells across all three domains of life to become commonplace. Single-molecule live-cell data is…
We demonstrate that the permeability of the cell wall of microalga $\textit{C. reinhardtii}$ can be enhanced in controlled microstreaming flow conditions using single bubbles adherent to a wall and driven by ultrasound near their resonance…
We have developed a new technique to measure viscoelasticity in soft materials such as polymer solutions, by monitoring thermal fluctuations of embedded probe particles using laser interferometry in a microscope. Interferometry allows us to…
Visualizing elastic waves by noninvasive imaging has been useful for analyzing the mechanical properties of materials and tissues. However, the maximum wave frequency of elastography has been limited to ~10 kHz due to the finite sensitivity…
Accurate assessment of stiffness distribution is essential due to the critical role of single cell mechanobiology in the regulation of many vital cellular processes such as proliferation, adhesion, migration, and motility. Cell stiffness is…
Modelling of single cellulose fibres is usually performed by assuming homogenous properties, such as strength and Young s modulus, for the whole fibre. Additionally, the inhomogeneity in size and swelling behaviour along the fibre is often…
Elastic wave dispersion is studied in an octet truss lattice and compared with a designed rib lattice known to exhibit strong Cosserat elastic effects. Dispersion entails variation of wave speed with frequency. The phenomenon is…
The acoustic response of microbubbles (MBs) depends on their resonance frequency, which is dependent on MB size and shell properties. Monodisperse MBs with tunable shell properties are thus desirable for optimizing and controlling MB…
The transfer of mechanical signals through cells is a complex phenomenon. To uncover a new mechanotransduction pathway, we study the frequency-dependent transport of mechanical stimuli by single microtubules and small networks in a…
Cell membrane tension directly influences various cellular functions. In this study, we developed a method to estimate surface tension from time-series data. We obtained the curvature-velocity relationship from time-series of binarized cell…
A way forward for high throughput fabrication of microcapsules with uniform size and mechanical properties was reported irrespective of the kinetic process of shell assembly. Microcapsules were produced using lab-scale emulsification…
Elastic wave propagation is intrinsically sensitive to the mechanical properties of the medium through which it travels. In soft elastomers, this makes guided elastic waves natural probes of viscoelastic and acoustoelastic behavior over a…
Shear-wave elastography (SWE) measures shear-wave speed (SWS), which is related to the underlying shear modulus of soft tissue. SWE methods generally assume that soft tissue viscoelasticity is independent of mechanical loading, however,…
We introduce a model-based iterative method to obtain shear modulus images of tissue using magnetic resonance elastography. The method jointly finds the displacement field that best fits multifrequency tissue displacement data and the…
In vivo measurement of the mechanical properties of thin-walled soft tissues (e.g., mitral valve, artery and bladder) and in situ mechanical characterization of thin-walled artificial soft biomaterials in service are of great challenge and…
Softer means stickier for solid adhesives, because material compliance facilitates close contact between non-conformal surfaces. Recent discoveries have revealed that soft materials can exhibit a rich array of new physics arising from…
This study presents the first observation of shear wave induced remotely within soft tissues. It was performed through the combination of a transcranial magnetic stimulation device and a permanent magnet. A physical model based on Maxwell…