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Protein-ligand binding affinity is critical in drug discovery, but experimentally determining it is time-consuming and expensive. Artificial intelligence (AI) has been used to predict binding affinity, significantly accelerating this…

Emerging Technologies · Computer Science 2025-09-16 Seon-Geun Jeong , Kyeong-Hwan Moon , Won-Joo Hwang

Due to the immense potential of quantum computers and the significant computing overhead required in machine learning applications, the variational quantum classifier (VQC) has received a lot of interest recently for image classification.…

Quantum Physics · Physics 2022-12-20 Ruiyang Qin , Zhiding Liang , Jinglei Cheng , Peter Kogge , Yiyu Shi

The search for useful applications of noisy intermediate-scale quantum (NISQ) devices in quantum simulation has been hindered by their intrinsic noise and the high costs associated with achieving high accuracy. A promising approach to…

Quantum Physics · Physics 2025-07-01 Emiel Koridon , Felix Frohnert , Eric Prehn , Evert van Nieuwenburg , Jordi Tura , Stefano Polla

Quantum machine learning (QML) is promising for potential speedups and improvements in conventional machine learning (ML) tasks (e.g., classification/regression). The search for ideal QML models is an active research field. This includes…

Quantum Physics · Physics 2022-02-07 Mahabubul Alam , Swaroop Ghosh

Natural language processing (NLP) problems are ubiquitous in classical computing, where they often require significant computational resources to infer sentence meanings. With the appearance of quantum computing hardware and simulators, it…

Quantum Physics · Physics 2020-10-09 Lee J. O'Riordan , Myles Doyle , Fabio Baruffa , Venkatesh Kannan

The integration of quantum machine learning with classical deep learning offers promising avenues for medical image analysis by mapping data into high-dimensional Hilbert spaces. However, effectively unifying these distinct paradigms…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Yasmin Rodrigues Sobrinho , João Renato Ribeiro Manesco , João Paulo Papa

High-dimensional quantum systems are vital for quantum technologies and are essential in demonstrating practical quantum advantage in quantum computing, simulation and sensing. Since dimensionality grows exponentially with the number of…

Quantum Physics · Physics 2020-07-01 Nana Liu , Peter Wittek

Quantum machine learning has emerged as a promising application domain for near-term quantum hardware, particularly through hybrid quantum-classical models that leverage both classical and quantum processing. Although numerous hybrid…

Quantum Physics · Physics 2026-01-09 Dominik Freinberger , Philipp Moser

The functional characterization of different neuronal types has been a longstanding and crucial challenge. With the advent of physical quantum computers, it has become possible to apply quantum machine learning algorithms to translate…

Quantum Physics · Physics 2025-02-11 Xavier Vasques , Hanhee Paik , Laura Cif

Noisy Intermediate-Scale Quantum (NISQ) technology will be available in the near future. Quantum computers with 50-100 qubits may be able to perform tasks which surpass the capabilities of today's classical digital computers, but noise in…

Quantum Physics · Physics 2018-08-08 John Preskill

Recently, there has been growing attention on combining quantum machine learning (QML) with classical deep learning approaches, as computational techniques are key to improving the performance of image classification tasks. This study…

Machine Learning · Computer Science 2025-10-29 Md. Farhan Shahriyar , Gazi Tanbhir , Abdullah Md Raihan Chy

Quantum search algorithm (also known as Grover's algorithm) lays the foundation for many other quantum algorithms. Although it is very simple, its implementation is limited on noisy intermediate-scale quantum (NISQ) processors. Grover's…

Quantum Physics · Physics 2022-09-28 Kun Zhang , Kwangmin Yu , Vladimir Korepin

We propose digital-analog quantum kernels for enhancing the detection of complex features in the classification of images. We consider multipartite-entangled analog blocks, stemming from native Ising interactions in neutral-atom quantum…

We address the problem of implementing bottleneck layers from classical pre-trained neural networks on a quantum computer, with the goal of exploring intrinsically quantum ansatz for representing large linear layers within hybrid…

Quantum Physics · Physics 2026-04-09 Borja Aizpurua , Sukhbinder Singh , Román Orús

Variational quantum algorithms provide a direct, physics-based approach to protein structure prediction, but their accuracy is limited by the coarse resolution of the energy landscapes generated on current noisy devices. We propose a hybrid…

Emerging Technologies · Computer Science 2025-10-09 Yuqi Zhang , Yuxin Yang , Feixiong Chen , Cheng-Chang Lu , Nima Saeidi , Samuel L. Volchenboum , Junhan Zhao , Siwei Chen , Weiwen Jiang , Qiang Guan

A novel hybrid quantum-classical approach has been developed to efficiently address the multireference quantum chemistry problem. The Handover Iterative Variational Quantum Eigensolver (HiVQE) is designed to accurately estimate ground-state…

Hybrid Quantum-Classical Machine Learning (ML) is an emerging field, amalgamating the strengths of both classical neural networks and quantum variational circuits on the current noisy intermediate-scale quantum devices. This paper performs…

The variational quantum eigensolver is a promising way to solve the Schr\"odinger equation on a noisy intermediate-scale quantum (NISQ) computer, while its success relies on a well-designed wavefunction ansatz. Compared to physically…

Quantum Physics · Physics 2023-01-20 Xiongzhi Zeng , Yi Fan , Jie Liu , Zhenyu Li , Jinlong Yang

The current state of quantum computing is commonly described as the Noisy Intermediate-Scale Quantum era. Available computers contain a few dozens of qubits and can perform a few dozens of operations before the inevitable noise erases all…

Quantum Physics · Physics 2024-09-25 Ijaz Ahamed Mohammad , Matej Pivoluska , Martin Plesch

The photonic platform holds great promise for quantum computing. Nevertheless, the intrinsic probabilistic characteristics of its native fusion operations introduces substantial randomness into the computing process, posing significant…

Quantum Physics · Physics 2025-04-29 Hezi Zhang , Jixuan Ruan , Hassan Shapourian , Ramana Rao Kompella , Yufei Ding