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Objective Neoadjuvant chemotherapy (NACT) is one kind of treatment for advanced stage ovarian cancer patients. However, due to the nature of tumor heterogeneity, the clinical outcomes to NACT vary significantly among different subgroups.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-04 Ke Zhang , Neman Abdoli , Patrik Gilley , Youkabed Sadri , Xuxin Chen , Theresa C. Thai , Lauren Dockery , Kathleen Moore , Robert S. Mannel , Yuchen Qiu

Objectives: High-grade serous ovarian carcinoma (HGSOC) is typically diagnosed at an advanced stage with extensive peritoneal metastases, making treatment challenging. Neoadjuvant chemotherapy (NACT) is often used to reduce tumor burden…

We proposed a novel convolutional restricted Boltzmann machine CRBM-based radiomic method for predicting pathologic complete response (pCR) to neoadjuvant chemotherapy treatment (NACT) in breast cancer. The method consists of extracting…

Image and Video Processing · Electrical Eng. & Systems 2019-06-03 Li Wang , Lihui Wang , Qijian Chen , Caixia Sun , Xinyu Cheng , Yuemin Zhu

Triple-negative breast cancer (TNBC) remains a major clinical challenge due to its aggressive behavior and lack of targeted therapies. Accurate early prediction of response to neoadjuvant chemotherapy (NACT) is essential for guiding…

Quantitative Methods · Quantitative Biology 2025-07-29 Hikmat Khan , Ziyu Su , Huina Zhang , Yihong Wang , Bohan Ning , Shi Wei , Hua Guo , Zaibo Li , Muhammad Khalid Khan Niazi

Effective surgical planning for breast cancer hinges on accurately predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). Diffusion-weighted MRI (DWI) and machine learning offer a non-invasive approach for early…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Shir Nitzan , Maya Gilad , Moti Freiman

Neoadjuvant chemotherapy (NAC) is a common therapy option before the main surgery for breast cancer. Response to NAC is monitored using follow-up dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Accurate prediction of NAC…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Jonghun Kim , Hyunjin Park

Objectives: To evaluate the association between pretreatment MRI descriptors and breast cancer (BC) pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). Materials \& Methods: Patients with BC treated by NAC with a breast…

Neoadjuvant chemotherapy (NAC) is a standard-of-care treatment for locally advanced triple negative breast cancer (TNBC) before surgery. The early assessment of TNBC response to NAC would enable an oncologist to adapt the therapeutic plan…

Tissues and Organs · Quantitative Biology 2022-12-09 Guillermo Lorenzo , Angela M. Jarrett , Christian T. Meyer , Vito Quaranta , Darren R. Tyson , Thomas E. Yankeelov

Clinicians compare breast DCE-MRI after neoadjuvant chemotherapy (NAC) with pre-treatment scans to evaluate the response to NAC. Clinical evidence supports that accurate longitudinal deformable registration without deforming treated tumor…

Image and Video Processing · Electrical Eng. & Systems 2024-01-18 Luyi Han , Tao Tan , Tianyu Zhang , Yuan Gao , Xin Wang , Valentina Longo , Sofía Ventura-Díaz , Anna D'Angelo , Jonas Teuwen , Ritse Mann

Radiomic features achieve promising results in cancer diagnosis, treatment response prediction, and survival prediction. Our goal is to compare the handcrafted (explicitly designed) and deep learning (DL)-based radiomic features extracted…

Effective therapy decisions require models that predict the individual response to treatment. This is challenging since the progression of disease and response to treatment vary substantially across patients. Here, we propose to learn a…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Ivana Janíčková , Yen Y. Tan , Thomas H. Helbich , Konstantin Miloserdov , Zsuzsanna Bago-Horvath , Ulrike Heber , Georg Langs

Early prediction of pathological complete response (pCR) following neoadjuvant chemotherapy (NAC) for breast cancer plays a critical role in surgical planning and optimizing treatment strategies. Recently, machine and deep-learning based…

Image and Video Processing · Electrical Eng. & Systems 2022-06-14 Maya Gilad , Moti Freiman

Monitoring Neoadjuvant chemotherapy (NAC) effects is necessary to capture resistant patients and stop or change treatment. The aim of this study was to assess the tumor response at an early stage, after the first doses of the NAC, based on…

Objective: This paper proposes a deep learning model for breast cancer detection from reconstructed images of microwave imaging scan data and aims to improve the accuracy and efficiency of breast tumor detection, which could have a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-21 Gayathri Girish , Ponnathota Spandana , Badrish Vasu

Neoadjuvant chemotherapy (NAC) has become a standard clinical practice for tumor downsizing in breast cancer with 18F-FDG Positron Emission Tomography (PET). Our work aims to leverage PET imaging for the segmentation of breast lesions. The…

Computer Vision and Pattern Recognition · Computer Science 2025-02-07 Tewele W. Tareke , Neree Payan , Alexandre Cochet , Laurent Arnould , Benoit Presles , Jean-Marc Vrigneaud , Fabrice Meriaudeau , Alain Lalande

Ovarian cancer is the most lethal gynecologic malignancy: around 60% of patients are diagnosed at an advanced stage, with an associated 5-year survival rate of about 30%. Early identification of non-responders to neoadjuvant chemotherapy…

Patients with metastatic breast cancer (mBC) undergo continuous medical imaging during treatment, making accurate lesion detection and monitoring over time critical for clinical decisions. Predicting drug response from post-treatment data…

Image and Video Processing · Electrical Eng. & Systems 2025-01-22 Subrata Mukherjee

Breast cancer is the most prevalent cancer among women and predicting pathologic complete response (pCR) after anti-cancer treatment is crucial for patient prognosis and treatment customization. Deep learning has shown promise in medical…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Jonghun Kim , Hyunjin Park

A standard treatment protocol for breast cancer entails administering neoadjuvant therapy followed by surgical removal of the tumor and surrounding tissue. Pathologists typically rely on cabinet X-ray radiographs, known as Faxitron, to…

Image and Video Processing · Electrical Eng. & Systems 2024-01-19 Negar Golestani , Aihui Wang , Gregory R Bean , Mirabela Rusu

Predicting response to neoadjuvant therapy is a vexing challenge in breast cancer. In this study, we evaluate the ability of deep learning to predict response to HER2-targeted neo-adjuvant chemotherapy (NAC) from pre-treatment dynamic…

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