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Multiple Instance Learning (MIL) has emerged as a dominant paradigm to extract discriminative feature representations within Whole Slide Images (WSIs) in computational pathology. Despite driving notable progress, existing MIL approaches…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Shu Yang , Yihui Wang , Hao Chen

Recently, pathological diagnosis has achieved superior performance by combining deep learning models with the multiple instance learning (MIL) framework using whole slide images (WSIs). However, the giga-pixeled nature of WSIs poses a great…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Zijie Fang , Yifeng Wang , Ye Zhang , Zhi Wang , Jian Zhang , Xiangyang Ji , Yongbing Zhang

Whole Slide Image (WSI) analysis is pivotal in computational pathology, enabling cancer diagnosis by integrating morphological and architectural cues across magnifications. Multiple Instance Learning (MIL) serves as the standard framework…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Sicheng Chen , Chad Wong , Tianyi Zhang , Enhui Chai , Zeyu Liu , Fei Xia

Whole slide image (WSI) analysis heavily relies on multiple instance learning (MIL). While recent methods benefit from large-scale foundation models and advanced sequence modeling to capture long-range dependencies, they still struggle with…

Image and Video Processing · Electrical Eng. & Systems 2026-03-23 Lubin Gan , Jing Zhang , Heng Zhang , Xin Di , Zhifeng Wang , Wenke Huang , Xiaoyan Sun

Whole-slide image (WSI) analysis is challenging due to the gigapixel scale of slides and their inherent hierarchical multi-resolution structure. Existing multiple instance learning (MIL) approaches often model WSIs as unordered collections…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Dongqing Xie , Yonghuang Wu

Computational pathology (CPath) has significantly advanced the clinical practice of pathology. Despite the progress made, Multiple Instance Learning (MIL), a promising paradigm within CPath, continues to face challenges, particularly…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Yuqi Zhang , Xiaoqian Zhang , Jiakai Wang , Yuancheng Yang , Taiying Peng , Chao Tong

Histopathology plays a critical role in medical diagnostics, with whole slide images (WSIs) offering valuable insights that directly influence clinical decision-making. However, the large size and complexity of WSIs may pose significant…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Zhongwei Qiu , Hanqing Chao , Tiancheng Lin , Wanxing Chang , Zijiang Yang , Wenpei Jiao , Yixuan Shen , Yunshuo Zhang , Yelin Yang , Wenbin Liu , Hui Jiang , Yun Bian , Ke Yan , Dakai Jin , Le Lu

Digitizing pathological images into gigapixel Whole Slide Images (WSIs) has opened new avenues for Computational Pathology (CPath). As positive tissue comprises only a small fraction of gigapixel WSIs, existing Multiple Instance Learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Wenhao Tang , Sheng Huang , Heng Fang , Fengtao Zhou , Bo Liu , Qingshan Liu

Whole slide images (WSIs) classification represents a fundamental challenge in computational pathology, where multiple instance learning (MIL) has emerged as the dominant paradigm. Current state-of-the-art (SOTA) MIL methods rely on…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Chengying She , Chengwei Chen , Dongjie Fan , Lizhuang Liu , Chengwei Shao , Yun Bian , Ben Wang , Xinran Zhang

Efficiently modeling large 2D contexts is essential for various fields including Giga-Pixel Whole Slide Imaging (WSI) and remote sensing. Transformer-based models offer high parallelism but face challenges due to their quadratic complexity…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Jingwei Zhang , Anh Tien Nguyen , Xi Han , Vincent Quoc-Huy Trinh , Hong Qin , Dimitris Samaras , Mahdi S. Hosseini

Multiple Instance Learning (MIL) represents the predominant framework in Whole Slide Image (WSI) classification, covering aspects such as sub-typing, diagnosis, and beyond. Current MIL models predominantly rely on instance-level features…

Computer Vision and Pattern Recognition · Computer Science 2024-07-26 Heng Fang , Sheng Huang , Wenhao Tang , Luwen Huangfu , Bo Liu

Multiple instance learning (MIL) has become the leading approach for extracting discriminative features from whole slide images (WSIs) in computational pathology. Attention-based MIL methods can identify key patches but tend to overlook…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Lubin Gan , Xiaoman Wu , Jing Zhang , Zhifeng Wang , Linhao Qu , Siying Wu , Xiaoyan Sun

Whole slide image (WSI) classification often relies on deep weakly supervised multiple instance learning (MIL) methods to handle gigapixel resolution images and slide-level labels. Yet the decent performance of deep learning comes from…

Computer Vision and Pattern Recognition · Computer Science 2022-07-06 Jiawei Yang , Hanbo Chen , Yu Zhao , Fan Yang , Yao Zhang , Lei He , Jianhua Yao

Whole Slide Images (WSIs) in histopathology pose a significant challenge for extensive medical image analysis due to their ultra-high resolution, massive scale, and intricate spatial relationships. Although existing Multiple Instance…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Jiaxuan Lu , Yuhui Lin , Junyan Shi , Fang Yan , Dongzhan Zhou , Yue Gao , Xiaosong Wang

Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Jiangping Wen , Jinyu Wen , Meie Fang

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Honglin Li , Yunlong Zhang , Chenglu Zhu , Jiatong Cai , Sunyi Zheng , Lin Yang

Multiple Instance Learning (MIL) methods allow for gigapixel Whole-Slide Image (WSI) analysis with only slide-level annotations. Interpretability is crucial for safely deploying such algorithms in high-stakes medical domains. Traditional…

Computer Vision and Pattern Recognition · Computer Science 2025-01-07 Susu Sun , Leslie Tessier , Frédérique Meeuwsen , Clément Grisi , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Multi-Instance Learning (MIL) has shown impressive performance for histopathology whole slide image (WSI) analysis using bags or pseudo-bags. It involves instance sampling, feature representation, and decision-making. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2024-03-14 Tingting Zheng , Kui Jiang , Hongxun Yao

We introduce Multi-scale Adaptive Recurrent Biomedical Linear-time Encoder (MARBLE), the first \textit{purely Mamba-based} multi-state multiple instance learning (MIL) framework for whole-slide image (WSI) analysis. MARBLE processes…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Jagan Mohan Reddy Dwarampudi , Joshua Wong , Hien Van Nguyen , Tania Banerjee

Histopathological whole slide image (WSI) analysis with deep learning has become a research focus in computational pathology. The current paradigm is mainly based on multiple instance learning (MIL), in which approaches with Transformer as…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hongbo Chu , Qiehe Sun , Jiawen Li , Yuxuan Chen , Lizhong Zhang , Tian Guan , Anjia Han , Yonghong He
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