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A basic assumption of molecular biology is that proteins sharing close three-dimensional (3D) structures are likely to share a common function and in most cases derive from a same ancestor. Computing the similarity between two protein…

Quantitative Methods · Quantitative Biology 2009-02-02 Noël Malod-Dognin , Rumen Andonov , Nicola Yanev

Learning linear combinations of multiple kernels is an appealing strategy when the right choice of features is unknown. Previous approaches to multiple kernel learning (MKL) promote sparse kernel combinations to support interpretability and…

Machine Learning · Computer Science 2010-10-28 Marius Kloft , Ulf Brefeld , Soeren Sonnenburg , Alexander Zien

In computational complexity theory, a decision problem is NP-complete when it is both in NP and NP-hard. Although a solution to a NP-complete can be verified quickly, there is no known algorithm to solve it in polynomial time. There exists…

Computational Complexity · Computer Science 2018-03-28 Wenxia Guo , Jin Wang , Majun He , Xiaoqin Ren , Wenhong Tian , Qingxian Wang

The efficacy of family-based approaches to mixture model-based clustering and classification depends on the selection of parsimonious models. Current wisdom suggests the Bayesian information criterion (BIC) for mixture model selection.…

Methodology · Statistics 2013-11-12 Sakyajit Bhattacharya , Paul D. McNicholas

A common challenge in real-time operations is deciding whether to re-solve an optimization problem or continue using an existing solution. While modern data platforms may collect information at high frequencies, many real-time operations…

Machine Learning · Computer Science 2025-09-30 Rui Ai , Hugo De Oliveira Barbalho , Sirui Li , Alexei Robsky , David Simchi-Levi , Ishai Menache

Mixed integer linear programming (MILP) is a powerful representation often used to formulate decision-making problems under uncertainty. However, it lacks a natural mechanism to reason about objects, classes of objects, and relations.…

Logic in Computer Science · Computer Science 2012-05-14 Geoffrey Gordon , Sue Ann Hong , Miroslav Dudik

We present exact mixed-integer linear programming formulations for verifying the performance of first-order methods for parametric quadratic optimization. We formulate the verification problem as a mixed-integer linear program where the…

Optimization and Control · Mathematics 2026-05-29 Vinit Ranjan , Jisun Park , Stefano Gualandi , Andrea Lodi , Bartolomeo Stellato

In this paper, we investigate combining blocking and collapsing -- two widely used strategies for improving the accuracy of Gibbs sampling -- in the context of probabilistic graphical models (PGMs). We show that combining them is not…

Artificial Intelligence · Computer Science 2013-09-27 Deepak Venugopal , Vibhav Gogate

This study explores distributed optimization problems with clique-wise coupling via operator splitting and how we can utilize this framework for performance analysis and enhancement. This framework extends beyond conventional pairwise…

Optimization and Control · Mathematics 2025-06-24 Yuto Watanabe , Kazunori Sakurama

A class of two-bit bit flipping algorithms for decoding low-density parity-check codes over the binary symmetric channel was proposed in [1]. Initial results showed that decoders which employ a group of these algorithms operating in…

Information Theory · Computer Science 2012-05-22 Dung Viet Nguyen , Bane Vasic , Michael W. Marcellin

Linear Predictive Clustering (LPC) partitions samples based on shared linear relationships between feature and target variables, with numerous applications including marketing, medicine, and education. Greedy optimization methods, commonly…

Machine Learning · Computer Science 2026-04-08 Jiazhou Liang , Hassan Khurram , Scott Sanner

Through in-context learning (ICL), large-scale language models are effective few-shot learners without additional model fine-tuning. However, the ICL performance does not scale well with the number of available training samples as it is…

Computation and Language · Computer Science 2023-06-16 Hyunsoo Cho , Hyuhng Joon Kim , Junyeob Kim , Sang-Woo Lee , Sang-goo Lee , Kang Min Yoo , Taeuk Kim

We present an improved library for the ranking problem called RPLIB. RPLIB includes the following data and features. (1) Real and artificial datasets of both pairwise data (i.e., information about the ranking of pairs of items) and feature…

Databases · Computer Science 2022-06-24 Paul E. Anderson , Brandon Tat , Charlie Ward , Amy N. Langville , Kathryn E. Pedings-Behling

Detectability of failures of linear programming (LP) decoding and its potential for improvement by adding new constraints motivate the use of an adaptive approach in selecting the constraints for the LP problem. In this paper, we make a…

Information Theory · Computer Science 2007-07-13 Mohammad H. Taghavi N. , Paul H. Siegel

MIML library is a Java software tool to develop, test, and compare classification algorithms for multi-instance multi-label (MIML) learning. The library includes 43 algorithms and provides a specific format and facilities for data managing…

Machine Learning · Computer Science 2024-02-14 Álvaro Belmonte , Amelia Zafra , Eva Gibaja

Valid statistical inference is challenging when the sample is subject to unknown selection bias. Data integration can be used to correct for selection bias when we have a parallel probability sample from the same population with some common…

Methodology · Statistics 2023-07-24 Zhonglei Wang , Shu Yang , Jae Kwang Kim

One of the most fundamental tasks in data science is to assist a user with unknown preferences in finding high-utility tuples within a large database. To accurately elicit the unknown user preferences, a widely-adopted way is by asking the…

Databases · Computer Science 2023-07-07 Guangyi Zhang , Nikolaj Tatti , Aristides Gionis

Compared to supervised variable selection, the research on unsupervised variable selection is far behind. A forward partial-variable clustering full-variable loss (FPCFL) method is proposed for the corresponding challenges. An advantage is…

Methodology · Statistics 2024-12-02 Tonglin Zhang , Huyunting Huang

Next-generation sequencing techniques have facilitated a large scale analysis of human genetic variation. Despite the advances in sequencing speeds, the computational discovery of structural variants is not yet standard. It is likely that…

Piecewise regression is a versatile approach used in various disciplines to approximate complex functions from limited, potentially noisy data points. In control, piecewise regression is, e.g., used to approximate the optimal control law of…

Optimization and Control · Mathematics 2024-07-10 Dieter Teichrib , Moritz Schulze Darup
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