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Automated semantic segmentation of cell nuclei in microscopic images is crucial for disease diagnosis and tissue microenvironment analysis. Nonetheless, this task presents challenges due to the complexity and heterogeneity of cells. While…

Image and Video Processing · Electrical Eng. & Systems 2023-08-10 Zhuchen Shao , Sourya Sengupta , Hua Li , Mark A. Anastasio

Score-based diffusion models are a highly effective method for generating samples from a distribution of images. We consider scenarios where the training data comes from a noisy version of the target distribution, and present an efficiently…

Machine Learning · Statistics 2025-09-30 Dennis Elbrächter , Giovanni S. Alberti , Matteo Santacesaria

MedSAM, a medical foundation model derived from the SAM architecture, has demonstrated notable success across diverse medical domains. However, its clinical application faces two major challenges: the dependency on labor-intensive manual…

Image and Video Processing · Electrical Eng. & Systems 2025-04-17 Peng Huang , Shu Hu , Bo Peng , Xun Gong , Penghang Yin , Hongtu Zhu , Xi Wu , Xin Wang

In recent years, extending variational autoencoder's framework to learn disentangled representations has received much attention. We address this problem by proposing a framework capable of disentangling class-related and class-independent…

Machine Learning · Computer Science 2021-02-02 Sina Hajimiri , Aryo Lotfi , Mahdieh Soleymani Baghshah

We study variance reduction for score estimation and diffusion-based sampling in settings where the clean (target) score is available or can be approximated. Starting from the Target Score Identity (TSI), which expresses the noisy marginal…

Machine Learning · Statistics 2026-01-26 Alois Duston , Tan Bui-Thanh

Current generative models are able to generate high-quality artefacts but have been shown to struggle with compositional reasoning, which can be defined as the ability to generate complex structures from simpler elements. In this paper, we…

Machine Learning · Computer Science 2024-08-20 Giovanni Bindi , Philippe Esling

Combining Generative Adversarial Networks (GANs) with encoders that learn to encode data points has shown promising results in learning data representations in an unsupervised way. We propose a framework that combines an encoder and a…

Computer Vision and Pattern Recognition · Computer Science 2018-03-08 Tobias Hinz , Stefan Wermter

Learning Interpretable representation in medical applications is becoming essential for adopting data-driven models into clinical practice. It has been recently shown that learning a disentangled feature representation is important for a…

Machine Learning · Computer Science 2019-04-19 Mhd Hasan Sarhan , Abouzar Eslami , Nassir Navab , Shadi Albarqouni

Traditional transformer-based semantic segmentation relies on quantized embeddings. However, our analysis reveals that autoencoder accuracy on segmentation mask using quantized embeddings (e.g. VQ-VAE) is 8% lower than continuous-valued…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Masud Ahmed , Zahid Hasan , Syed Arefinul Haque , Abu Zaher Md Faridee , Sanjay Purushotham , Suya You , Nirmalya Roy

Diffusion models have recently emerged as powerful learners for simulation-based inference (SBI), enabling fast and accurate estimation of latent parameters from simulated and real data. Their score-based formulation offers a flexible way…

Machine Learning · Statistics 2026-01-30 Jonas Arruda , Niels Bracher , Ullrich Köthe , Jan Hasenauer , Stefan T. Radev

Learning good representations is of crucial importance in deep learning. Mutual Information (MI) or similar measures of statistical dependence are promising tools for learning these representations in an unsupervised way. Even though the…

Audio and Speech Processing · Electrical Eng. & Systems 2019-04-09 Mirco Ravanelli , Yoshua Bengio

Unsupervised representation learning seeks to recover latent generative factors, yet standard methods relying on statistical independence often fail to capture causal dependencies. A central challenge is identifiability: as established in…

Machine Learning · Computer Science 2025-12-30 Hans Jarett J. Ong , Brian Godwin S. Lim , Dominic Dayta , Renzo Roel P. Tan , Kazushi Ikeda

We introduce the Mutual Information Machine (MIM), a novel formulation of representation learning, using a joint distribution over the observations and latent state in an encoder/decoder framework. Our key principles are symmetry and mutual…

Machine Learning · Statistics 2019-10-10 Micha Livne , Kevin Swersky , David J. Fleet

Denoising diffusion models produce high-fidelity image samples by capturing the image distribution in a progressive manner while initializing with a simple distribution and compounding the distribution complexity. Although these models have…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Ayantika Das , Moitreya Chaudhuri , Koushik Bhat , Keerthi Ram , Mihail Bota , Mohanasankar Sivaprakasam

Automated discovery of early visual concepts from raw image data is a major open challenge in AI research. Addressing this problem, we propose an unsupervised approach for learning disentangled representations of the underlying factors of…

Latent confounders are a fundamental challenge for inferring causal effects from observational data. The instrumental variable (IV) approach is a practical way to address this challenge. Existing IV based estimators need a known IV or other…

Machine Learning · Computer Science 2024-12-09 Debo Cheng , Jiuyong Li , Lin Liu , Ziqi Xu , Weijia Zhang , Jixue Liu , Thuc Duy Le

Diffusion models (DMs) have achieved state-of-the-art results for image synthesis tasks as well as density estimation. Applied in the latent space of a powerful pretrained autoencoder (LDM), their immense computational requirements can be…

Computer Vision and Pattern Recognition · Computer Science 2022-10-21 Jeremias Traub

In this paper, we investigate the problem of learning disentangled representations. Given a pair of images sharing some attributes, we aim to create a low-dimensional representation which is split into two parts: a shared representation…

Machine Learning · Statistics 2019-12-10 Eduardo Hugo Sanchez , Mathieu Serrurier , Mathias Ortner

Estimating direct and indirect causal effects from observational data is crucial to understanding the causal mechanisms and predicting the behaviour under different interventions. Causal mediation analysis is a method that is often used to…

Machine Learning · Computer Science 2023-12-19 Ziqi Xu , Debo Cheng , Jiuyong Li , Jixue Liu , Lin Liu , Ke Wang

Radiological images such as computed tomography (CT) and X-rays render anatomy with intrinsic structures. Being able to reliably locate the same anatomical structure across varying images is a fundamental task in medical image analysis. In…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Ke Yan , Jinzheng Cai , Dakai Jin , Shun Miao , Dazhou Guo , Adam P. Harrison , Youbao Tang , Jing Xiao , Jingjing Lu , Le Lu