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Related papers: DNAMotifTokenizer: Towards Biologically Informed T…

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Modeling biological sequences such as DNA, RNA, and proteins is crucial for understanding complex processes like gene regulation and protein synthesis. However, most current models either focus on a single type or treat multiple types of…

Genomics · Quantitative Biology 2024-10-16 Weixi Xiang , Xueting Han , Xiujuan Chai , Jing Bai

Subword tokenization critically affects Natural Language Processing (NLP) performance, yet its behavior in morphologically rich and low-resource language families remains under-explored. This study systematically compares three subword…

Computation and Language · Computer Science 2026-03-31 Nuo Xu , Ahrii Kim

The task of understanding and interpreting the complex information encoded within genomic sequences remains a grand challenge in biological research and clinical applications. In this context, recent advancements in large language model…

Genomics · Quantitative Biology 2024-09-25 Qihang Zhao , Chi Zhang , Weixiong Zhang

Tokenization is a critical part of modern NLP pipelines. However, contemporary tokenizers for Large Language Models are based on statistical analysis of text corpora, without much consideration to the linguistic features. I propose a…

Computation and Language · Computer Science 2024-02-06 Haris Jabbar

Gender-inclusive NLP research has documented the harmful limitations of gender binary-centric large language models (LLM), such as the inability to correctly use gender-diverse English neopronouns (e.g., xe, zir, fae). While data scarcity…

Computation and Language · Computer Science 2024-04-09 Anaelia Ovalle , Ninareh Mehrabi , Palash Goyal , Jwala Dhamala , Kai-Wei Chang , Richard Zemel , Aram Galstyan , Yuval Pinter , Rahul Gupta

A common problem in bioinformatics is related to identifying gene regulatory regions marked by relatively high frequencies of motifs, or deoxyribonucleic acid sequences that often code for transcription and enhancer proteins. Predicting…

Genomics · Quantitative Biology 2021-01-22 Ethan Jacob Moyer , Anup Das

Existing time series tokenization methods predominantly encode a constant number of samples into individual tokens. This inflexible approach can generate excessive tokens for even simple patterns like extended constant values, resulting in…

Machine Learning · Computer Science 2026-01-29 Leon Götz , Marcel Kollovieh , Stephan Günnemann , Leo Schwinn

Discrete audio tokens derived from self-supervised learning models have gained widespread usage in speech generation. However, current practice of directly utilizing audio tokens poses challenges for sequence modeling due to the length of…

Sound · Computer Science 2024-01-17 Feiyu Shen , Yiwei Guo , Chenpeng Du , Xie Chen , Kai Yu

Large language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA, where sequences of nucleotides act as "words" that…

We present ensemble methods in a machine learning (ML) framework combining predictions from five known motif/binding site exploration algorithms. For a given TF the ensemble starts with position weight matrices (PWM's) for the motif,…

Genomics · Quantitative Biology 2018-05-11 Yue Fan , Mark Kon , Charles DeLisi

Typically, tokenization is the very first step in most text processing works. As a token serves as an atomic unit that embeds the contextual information of text, how to define a token plays a decisive role in the performance of a model.Even…

Computation and Language · Computer Science 2020-10-07 Kyubyong Park , Joohong Lee , Seongbo Jang , Dawoon Jung

Language models typically tokenize raw text into sequences of subword identifiers from a predefined vocabulary, a process inherently sensitive to typographical errors, length variations, and largely oblivious to the internal structure of…

Computation and Language · Computer Science 2024-10-07 Yekun Chai , Yewei Fang , Qiwei Peng , Xuhong Li

Tokenization is a promising path to multi-modal models capable of jointly understanding protein sequences, structure, and function. Existing protein structure tokenizers create tokens by pooling information from local neighborhoods, an…

Machine Learning · Computer Science 2026-02-09 Rohit Dilip , Ayush Varshney , David Van Valen

Byte-based machine translation systems have shown significant potential in massively multilingual settings. Unicode encoding, which maps each character to specific byte(s), eliminates the emergence of unknown words, even in new languages.…

Computation and Language · Computer Science 2025-02-10 Langlin Huang , Mengyu Bu , Yang Feng

This paper introduces Dynamic Programming Encoding (DPE), a new segmentation algorithm for tokenizing sentences into subword units. We view the subword segmentation of output sentences as a latent variable that should be marginalized out…

Computation and Language · Computer Science 2020-08-04 Xuanli He , Gholamreza Haffari , Mohammad Norouzi

This study investigates the impact of morphological typology on tokenization and language modeling performance. We focus on languages with synthetic and analytical morphological structures and examine their productivity when tokenized using…

Computation and Language · Computer Science 2024-11-01 Iñigo Parra

Gene promoters are the key DNA regulatory elements positioned around the transcription start sites and are responsible for regulating gene transcription process. Various alignment-based, signal-based and content-based approaches are…

Genomics · Quantitative Biology 2021-05-18 Nikita Bhandari , Satyajeet Khare , Rahee Walambe , Ketan Kotecha

Byte-Pair Encoding (BPE) is an algorithm commonly used in Natural Language Processing to build a vocabulary of subwords, which has been recently applied to symbolic music. Given that symbolic music can differ significantly from text,…

Information Retrieval · Computer Science 2024-10-03 Dinh-Viet-Toan Le , Louis Bigo , Mikaela Keller

Language models typically tokenize text into subwords, using a deterministic, hand-engineered heuristic of combining characters into longer surface-level strings such as 'ing' or whole words. Recent literature has repeatedly shown the…

Computation and Language · Computer Science 2023-10-19 Avijit Thawani , Saurabh Ghanekar , Xiaoyuan Zhu , Jay Pujara

Morphology is a crucial factor for multilingual language modeling as it poses direct challenges for tokenization. Here, we seek to understand how tokenization influences the morphological knowledge encoded in multilingual language models.…

Computation and Language · Computer Science 2024-10-23 Thao Anh Dang , Limor Raviv , Lukas Galke
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