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Single Particle Imaging techniques at X-ray lasers have made significant strides, yet the challenge of determining the orientation of freely rotating molecules during delivery remains. In this study, we propose a novel method to partially…

Chemical Physics · Physics 2025-10-27 Tomas André , Emiliano De Santis , Nicusor Timneanu , Carl Caleman

Existing 3D editing methods often produce unrealistic and unrefined results due to the deeply integrated nature of their reconstruction networks. To address the challenge, this paper introduces CEI-3D, an editing-oriented reconstruction…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Yue Shi , Rui Shi , Yuxuan Xiong , Bingbing Ni , Wenjun Zhang

Cryo-electron microscopy (cryo-EM) has become a tool of fundamental importance in structural biology, helping us understand the basic building blocks of life. The algorithmic challenge of cryo-EM is to jointly estimate the unknown 3D poses…

Computer Vision and Pattern Recognition · Computer Science 2022-09-01 Axel Levy , Frédéric Poitevin , Julien Martel , Youssef Nashed , Ariana Peck , Nina Miolane , Daniel Ratner , Mike Dunne , Gordon Wetzstein

Early diagnosis is essential for the successful treatment of bowel cancers including colorectal cancer (CRC) and capsule endoscopic imaging with robotic actuation can be a valuable diagnostic tool when combined with automated image…

The identification of the interfacial molecules in fluid-fluid equilibrium is a long-standing problem in the area of simulation. We here propose a new point of view, making use of concepts taken from the field of computational geometry,…

Soft Condensed Matter · Physics 2009-04-30 Florencio Balboa Usabiaga , Daniel Duque

D shape generation is a fundamental operation in computer graphics. While significant progress has been made, especially with recent deep generative models, it remains a challenge to synthesize high-quality shapes with rich geometric…

Graphics · Computer Science 2022-05-31 Jie Yang , Kaichun Mo , Yu-Kun Lai , Leonidas J. Guibas , Lin Gao

The fusion of rigorous physical laws with flexible data-driven learning represents a new frontier in scientific simulation, yet bridging the gap between physical interpretability and computational efficiency remains a grand challenge. In…

Representations are a foundational component of any modelling protocol, including on molecules and molecular solids. For tasks that depend on knowledge of both molecular conformation and 3D orientation, such as the modelling of molecular…

Machine Learning · Computer Science 2026-03-17 Michael Kilgour , Mark Tuckerman , Jutta Rogal

Spatial representation learning is essential for GeoAI applications such as urban analytics, enabling the encoding of shapes, locations, and spatial relationships (topological and distance-based) of geo-entities like points, polylines, and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Chen Chu , Cyrus Shahabi

Deep learning has led to a paradigm shift in artificial intelligence, including web, text and image search, speech recognition, as well as bioinformatics, with growing impact in chemical physics. Machine learning in general and deep…

Machine learning methods are being introduced at all stages of data reconstruction and analysis in various high-energy physics experiments. We present the development and application of convolutional neural networks with modified…

Instrumentation and Detectors · Physics 2025-04-25 Kalina Dimitrova , Venelin Kozhuharov , Peicho Petkov

Modern deep learning developments create new opportunities for 3D mapping technology, scene reconstruction pipelines, and virtual reality development. Despite advances in 3D deep learning technology, direct training of deep learning models…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Xueyang Kang

Group equivariance (e.g. SE(3) equivariance) is a critical physical symmetry in science, from classical and quantum physics to computational biology. It enables robust and accurate prediction under arbitrary reference transformations. In…

Computational Engineering, Finance, and Science · Computer Science 2023-02-08 Weitao Du , He Zhang , Yuanqi Du , Qi Meng , Wei Chen , Bin Shao , Tie-Yan Liu

Denoising diffusion probabilistic models (DDPMs) have pioneered new state-of-the-art results in disciplines such as computer vision and computational biology for diverse tasks ranging from text-guided image generation to structure-guided…

Machine Learning · Computer Science 2024-05-28 Alex Morehead , Jianlin Cheng

Recent developments in many-body potential energy representation via deep learning have brought new hopes to addressing the accuracy-versus-efficiency dilemma in molecular simulations. Here we describe DeePMD-kit, a package written in…

Computational Physics · Physics 2018-05-23 Han Wang , Linfeng Zhang , Jiequn Han , Weinan E

The interest in matching non-rigidly deformed shapes represented as raw point clouds is rising due to the proliferation of low-cost 3D sensors. Yet, the task is challenging since point clouds are irregular and there is a lack of intrinsic…

Computer Vision and Pattern Recognition · Computer Science 2025-01-10 Huajian Zeng , Maolin Gao , Daniel Cremers

Determining the stability of chemical compounds is essential for advancing material discovery. In this study, we introduce a novel deep neural network model designed to predict a crystal's formation energy, which identifies its stability…

Materials Science · Physics 2026-04-21 V. Torlao , E. A. Fajardo

Machine learning has enabled the prediction of quantum chemical properties with high accuracy and efficiency, allowing to bypass computationally costly ab initio calculations. Instead of training on a fixed set of properties, more recent…

A major challenge in computational chemistry is the generation of novel molecular structures with desirable pharmacological and physiochemical properties. In this work, we investigate the potential use of autoencoder, a deep learning…

Machine Learning · Computer Science 2017-11-22 Thomas Blaschke , Marcus Olivecrona , Ola Engkvist , Jürgen Bajorath , Hongming Chen

Quantum geometrical molecular dynamics provides a quantum geometric picture for understanding reactive dynamics, especially excited-state conical intersection dynamics, and also a numerically exact method for strongly correlated…

Chemical Physics · Physics 2026-01-26 Mo Sha , Bing Gu
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