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Spiking Neural Networks (SNNs) are energy-efficient and biologically plausible, ideal for embedded and security-critical systems, yet their adversarial robustness remains open. Existing adversarial attacks often overlook SNNs' bio-plausible…

Cryptography and Security · Computer Science 2026-04-03 Lingxin Jin , Wei Jiang , Maregu Assefa Habtie , Letian Chen , Jinyu Zhan , Xingzhi Zhou , Lin Zuo , Naoufel Werghi

Biologists frequently desire protein inhibitors for a variety of reasons, including use as research tools for understanding biological processes and application to societal problems in agriculture, healthcare, etc. Immunotherapy, for…

Machine Learning · Computer Science 2024-11-04 Po-Yu Liang , Jun Bai

As agents based on large language models are increasingly deployed to long-horizon tasks, maintaining their alignment with stakeholder preferences becomes critical. Effective alignment in such settings requires reward models that are…

Artificial Intelligence · Computer Science 2025-12-09 Charlie Masters , Marta Grześkiewicz , Stefano V. Albrecht

One of the several obstacles in the widespread use of AI systems is the lack of requirements of interpretability that can enable a layperson to ensure the safe and reliable behavior of such systems. We extend the analysis of an agent…

Artificial Intelligence · Computer Science 2021-08-24 Pulkit Verma , Siddharth Srivastava

Paper weakness identification using single-agent or multi-agent LLMs has attracted increasing attention, yet existing approaches exhibit key limitations. Many multi-agent systems simulate human roles at a surface level, missing the…

Artificial Intelligence · Computer Science 2026-02-19 Zhuoyang Zou , Abolfazl Ansari , Delvin Ce Zhang , Dongwon Lee , Wenpeng Yin

While AI innovation accelerates rapidly, the intellectual process behind breakthroughs -- how researchers identify gaps, synthesize prior work, and generate insights -- remains poorly understood. The lack of structured data on scientific…

Artificial Intelligence · Computer Science 2026-01-09 Jiachen Liu , Maestro Harmon , Zechen Zhang

Deep Research Agents (DRAs) aim to automatically produce analyst-level reports through iterative information retrieval and synthesis. However, most existing DRAs were validated on question-answering benchmarks, while research on generating…

The discovery of high-performance organic photocatalysts for hydrogen evolution remains limited by the vastness of chemical space and the reliance on human intuition for molecular design. Here we present ChemNavigator, an agentic AI system…

Chemical Physics · Physics 2026-01-27 Iman Peivaste , Ahmed Makradi , Salim Belouettar

Using machine learning, especially deep learning, to facilitate biological research is a fascinating research direction. However, in addition to the standard classification or regression problems, in bioinformatics, we often need to predict…

Quantitative Methods · Quantitative Biology 2020-08-31 Yu Li

Peptide-drug conjugates (PDCs) represent a promising therapeutic avenue for human diseases, particularly in cancer treatment. Systematic elucidation of structure-activity relationships (SARs) and accurate prediction of the activity of PDCs…

Machine Learning · Computer Science 2025-06-17 Yun Liu , Jintu Huang , Yingying Zhu , Congrui Wen , Yu Pang , Ji-Quan Zhang , Ling Wang

Model-based design of experiments (MBDOE) is essential for efficient parameter estimation in nonlinear dynamical systems. However, conventional adaptive MBDOE requires costly posterior inference and design optimization between each…

Machine Learning · Statistics 2026-03-25 Arno Strouwen , Sebastian Micluţa-Câmpeanu

A major bottleneck in search-based program synthesis is the exponentially growing search space which makes learning large programs intractable. Humans mitigate this problem by leveraging the compositional nature of the real world: In…

Artificial Intelligence · Computer Science 2024-12-25 Jonas Witt , Sebastijan Dumančić , Tias Guns , Claus-Christian Carbon

Recent agent frameworks and inference-time algorithms often struggle with complex planning problems due to limitations in verifying generated plans or reasoning and varying complexity of instances within a single task. Many existing methods…

The binding complexes formed by proteins and small molecule ligands are ubiquitous and critical to life. Despite recent advancements in protein structure prediction, existing algorithms are so far unable to systematically predict the…

Quantitative Methods · Quantitative Biology 2023-04-21 Zhuoran Qiao , Weili Nie , Arash Vahdat , Thomas F. Miller , Anima Anandkumar

Deep research systems, agentic AI that solve complex, multi-step tasks by coordinating reasoning, search across the open web and user files, and tool use, are moving toward hierarchical deployments with a Planner, Coordinator, and…

Artificial Intelligence · Computer Science 2025-11-06 Wenjun Li , Zhi Chen , Jingru Lin , Hannan Cao , Wei Han , Sheng Liang , Zhi Zhang , Kuicai Dong , Dexun Li , Chen Zhang , Yong Liu

Next-Generation Sequencing (NGS) has become a cornerstone of genomic research, yet the complexity of downstream analysis-ranging from differential expression gene (DEG) identification to biological interpretations-remains a significant…

Genomics · Quantitative Biology 2025-12-12 Donghyeon Lee , Dongseok Kim , Seokhwan Ko , Seo-Young Park , Junghwan Cho

Recent advances in large language models (LLMs) have propelled research in natural language interfaces to databases. However, most state-of-the-art text-to-SQL systems still depend on complex, multi-stage pipelines. This work proposes a…

Artificial Intelligence · Computer Science 2025-06-03 Fernando Granado , Roberto Lotufo , Jayr Pereira

Recent research has explored the use of Large Language Models (LLMs) for tackling complex graph reasoning tasks. However, due to the intricacies of graph structures and the inherent limitations of LLMs in handling long text, current…

Artificial Intelligence · Computer Science 2025-11-26 Yuwei Hu , Runlin Lei , Xinyi Huang , Zhewei Wei , Yongchao Liu

The integration of spiking neural networks (SNNs) with transformer-based architectures has opened new opportunities for bio-inspired low-power, event-driven visual reasoning on edge devices. However, the high temporal resolution and binary…

Hardware Architecture · Computer Science 2025-11-11 Tamoghno Das , Khanh Phan Vu , Hanning Chen , Hyunwoo Oh , Mohsen Imani

Interpreting the internal activations of neural networks can produce more faithful explanations of their behavior, but is difficult due to the complex structure of activation space. Existing approaches to scalable interpretability use…

Artificial Intelligence · Computer Science 2025-12-18 Vincent Huang , Dami Choi , Daniel D. Johnson , Sarah Schwettmann , Jacob Steinhardt