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Deep learning algorithms have become the golden standard for segmentation of medical imaging data. In most works, the variability and heterogeneity of real clinical data is acknowledged to still be a problem. One way to automatically…

Image and Video Processing · Electrical Eng. & Systems 2022-02-25 Arkadiy Dushatskiy , Gerry Lowe , Peter A. N. Bosman , Tanja Alderliesten

Post-training of LLMs with RLHF, and subsequently preference optimization algorithms such as DPO, IPO, etc., made a big difference in improving human alignment. However, all such techniques can only work with a single (human) objective. In…

Machine Learning · Computer Science 2025-05-19 Akhil Agnihotri , Rahul Jain , Deepak Ramachandran , Zheng Wen

This paper addresses the task of cross-modal medical image segmentation by exploring unsupervised domain adaptation (UDA) approaches. We propose a model-agnostic UDA framework, LowBridge, which builds on a simple observation that…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Pengfei Lyu , Pak-Hei Yeung , Xiaosheng Yu , Jing Xia , Jianning Chi , Chengdong Wu , Jagath C. Rajapakse

Large reasoning models (LRMs) generate intermediate reasoning traces before producing final answers, yielding strong gains on multi-step and mathematical tasks. Yet aligning LRMs with human preferences, a crucial prerequisite for model…

Machine Learning · Computer Science 2025-10-07 Mingkang Zhu , Xi Chen , Bei Yu , Hengshuang Zhao , Jiaya Jia

This paper presents Perceptual Preference Optimization (PerPO), a perception alignment method aimed at addressing the visual discrimination challenges in generative pre-trained multimodal large language models (MLLMs). To align MLLMs with…

Artificial Intelligence · Computer Science 2025-02-10 Zining Zhu , Liang Zhao , Kangheng Lin , Jinze Yang , En Yu , Chenglong Liu , Haoran Wei , Jianjian Sun , Zheng Ge , Xiangyu Zhang

This paper presents a simple yet effective two-stage framework for semi-supervised medical image segmentation. Unlike prior state-of-the-art semi-supervised segmentation methods that predominantly rely on pseudo supervision directly on…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Huimin Wu , Xiaomeng Li , Kwang-Ting Cheng

Existing self-supervised learning methods based on contrastive learning and masked image modeling have demonstrated impressive performances. However, current masked image modeling methods are mainly utilized in natural images, and their…

Computer Vision and Pattern Recognition · Computer Science 2023-02-28 Xiangtao Wang , Ruizhi Wang , Biao Tian , Jiaojiao Zhang , Shuo Zhang , Junyang Chen , Thomas Lukasiewicz , Zhenghua Xu

Generating visually appealing images is fundamental to modern text-to-image generation models. A potential solution to better aesthetics is direct preference optimization (DPO), which has been applied to diffusion models to improve general…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Zhanhao Liang , Yuhui Yuan , Shuyang Gu , Bohan Chen , Tiankai Hang , Mingxi Cheng , Ji Li , Liang Zheng

Direct Preference Optimization (DPO) is a widely adopted offline algorithm for preference-based reinforcement learning from human feedback (RLHF), designed to improve training simplicity and stability by redefining reward functions.…

Computation and Language · Computer Science 2025-05-30 Gengxu Li , Tingyu Xia , Yi Chang , Yuan Wu

Human preference alignment is critical in building powerful and reliable large language models (LLMs). However, current methods either ignore the multi-dimensionality of human preferences (e.g. helpfulness and harmlessness) or struggle with…

Machine Learning · Computer Science 2024-10-14 Xingzhou Lou , Junge Zhang , Jian Xie , Lifeng Liu , Dong Yan , Kaiqi Huang

Understanding the severity of conditions shown in images in medical diagnosis is crucial, serving as a key guide for clinical assessment, treatment, as well as evaluating longitudinal progression. This paper proposes Con- PrO: a novel…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Hong Nguyen , Hoang Nguyen , Melinda Chang , Hieu Pham , Shrikanth Narayanan , Michael Pazzani

Video generation techniques have achieved remarkable advancements in visual quality, yet faithfully reproducing real-world physics remains elusive. Preference-based model post-training may improve physical consistency, but requires costly…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Wenxu Qian , Chaoyue Wang , Hou Peng , Zhiyu Tan , Hao Li , Anxiang Zeng

Neural implicit mapping has emerged as a powerful paradigm for robotic navigation and scene understanding. However, real-world robotic deployment requires continual adaptation to changing environments under strict memory and computation…

Robotics · Computer Science 2026-05-29 Xunlan Zhou , Hongrui Zhao , Negar Mehr

Safety alignment of large language models remains brittle under domain shift and noisy preference supervision. Most existing robust alignment methods focus on uncertainty in alignment data, while overlooking optimization-induced fragility…

Machine Learning · Computer Science 2026-05-22 Yonghui Yang , Wenjian Tao , Jilong Liu , Xingyu Zhu , Junfeng Fang , Weibiao Huang , Le Wu , Richang Hong , Tat-Sent Chua

Existing studies on preference optimization (PO) have centered on constructing pairwise preference data following simple heuristics, such as maximizing the margin between preferred and dispreferred completions based on human (or AI) ranked…

Artificial Intelligence · Computer Science 2025-02-10 Zhuotong Chen , Fang Liu , Xuan Zhu , Yanjun Qi , Mohammad Ghavamzadeh

Language model (LM) post-training (or alignment) involves maximizing a reward function that is derived from preference annotations. Direct Preference Optimization (DPO) is a popular offline alignment method that trains a policy directly on…

Machine Learning · Computer Science 2025-03-04 Adam Fisch , Jacob Eisenstein , Vicky Zayats , Alekh Agarwal , Ahmad Beirami , Chirag Nagpal , Pete Shaw , Jonathan Berant

Reinforcement learning (RL) has become a powerful tool for post-training visual generative models, with Group Relative Policy Optimization (GRPO) increasingly used to align generators with human preferences. However, existing GRPO pipelines…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Ziqi Ni , Yuanzhi Liang , Rui Li , Yi Zhou , Haibin Huang , Chi Zhang , Xuelong Li

Direct Preference Optimization (DPO) has become a popular approach for aligning language models using pairwise preferences. However, in practical post-training pipelines, on-policy generation typically yields multiple candidate responses…

Machine Learning · Computer Science 2025-06-23 Taneesh Gupta , Rahul Madhavan , Xuchao Zhang , Nagarajan Natarajan , Chetan Bansal , Saravan Rajmohan

We introduce active generation of Pareto sets (A-GPS), a new framework for online discrete black-box multi-objective optimization (MOO). A-GPS learns a generative model of the Pareto set that supports a-posteriori conditioning on user…

Machine Learning · Computer Science 2025-12-18 Daniel M. Steinberg , Asiri Wijesinghe , Rafael Oliveira , Piotr Koniusz , Cheng Soon Ong , Edwin V. Bonilla

Learning from human feedback typically relies on preference optimization that constrains policy updates through token-level regularization. However, preference optimization for language models is particularly challenging because token-space…

Machine Learning · Computer Science 2026-02-03 Enyi Jiang , Yibo Jacky Zhang , Yinglun Xu , Andreas Haupt , Nancy Amato , Sanmi Koyejo