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Accurate exploration of protein conformational ensembles is essential for uncovering function but remains hard because molecular-dynamics (MD) simulations suffer from high computational costs and energy-barrier trapping. This paper presents…

Machine Learning · Computer Science 2025-11-14 Yuancheng Sun , Yuxuan Ren , Zhaoming Chen , Xu Han , Kang Liu , Qiwei Ye

Aligning text-to-video diffusion models with human preferences is crucial for generating high-quality videos. Existing Direct Preference Otimization (DPO) methods rely on multi-sample ranking and task-specific critic models, which is…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Zitong Huang , Kaidong Zhang , Yukang Ding , Chao Gao , Rui Ding , Ying Chen , Wangmeng Zuo

Text-to-image diffusion models deliver high-quality images, yet aligning them with human preferences remains challenging. We revisit diffusion-based Direct Preference Optimization (DPO) for these models and identify a critical pathology:…

Computer Vision and Pattern Recognition · Computer Science 2025-12-03 Minghao Fu , Guo-Hua Wang , Tianyu Cui , Qing-Guo Chen , Zhao Xu , Weihua Luo , Kaifu Zhang

Diffusion models have achieved remarkable success in conditional image generation, yet their outputs often remain misaligned with human preferences. To address this, recent work has applied Direct Preference Optimization (DPO) to diffusion…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Shaomeng Wang , He Wang , Xiaolu Wei , Longquan Dai , Jinhui Tang

Recent alignment methods based on Direct Preference Optimization (DPO) reformulate preference learning as supervised optimization over pairwise comparisons, offering improved efficiency and stability over reinforcement learning from human…

Machine Learning · Computer Science 2026-01-22 Yuhui Sun , Xiyao Wang , Zixi Li , YiTian Ding , Tianyang Ling , Jialuo Chen , Tianyi Yu , Zhenlong Yuan , Jinman Zhao

This paper presents a model-agnostic ensemble approach for supervised learning. The proposed approach is based on a parametric version of Random Subspace, in which each base model is learned from a feature subset sampled according to a…

Machine Learning · Computer Science 2023-01-23 Vân Anh Huynh-Thu , Pierre Geurts

Existing preference datasets for text-to-image models typically store only the final winner/loser images. This representation is insufficient for rectified flow (RF) models, whose generation is naturally indexed by a specific prior noise…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Yunhong Lu , Qichao Wang , Hengyuan Cao , Xiaoyin Xu , Min Zhang

Multi-preference optimization enriches language-model alignment beyond pairwise preferences by contrasting entire sets of helpful and undesired responses, thereby enabling richer training signals for large language models. During self-play…

Machine Learning · Computer Science 2025-06-10 Taneesh Gupta , Rahul Madhavan , Xuchao Zhang , Chetan Bansal , Saravan Rajmohan

Unsupervised pre-training has been proven as an effective approach to boost various downstream tasks given limited labeled data. Among various methods, contrastive learning learns a discriminative representation by constructing positive and…

Image and Video Processing · Electrical Eng. & Systems 2022-02-17 Jizong Peng , Ping Wang , Marco Pedersoli , Christian Desrosiers

Multi-objective Bayesian optimization (MOBO) provides a principled framework for optimizing expensive black-box functions with multiple objectives. However, existing MOBO methods often struggle with coverage, scalability with respect to the…

Machine Learning · Computer Science 2026-04-20 Yaohong Yang , Sammie Katt , Samuel Kaski

Direct preference optimization (DPO) methods have shown strong potential in aligning text-to-image diffusion models with human preferences by training on paired comparisons. These methods improve training stability by avoiding the REINFORCE…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Yi-Lun Wu , Bo-Kai Ruan , Chiang Tseng , Hong-Han Shuai

Direct Preference Optimization (DPO) has become a standard framework for safety alignment, but its reliance on pairwise preference updates makes training sensitive to imperfect supervision. Existing robust DPO methods often address this…

Machine Learning · Computer Science 2026-05-27 Jilong Liu , Yonghui Yang , Pengyang Shao , Wenjian Tao , Hao Zhan , Haokai Ma , Wei Qin , Richang Hong

Direct Preference Optimization (DPO) has recently been extended from text-only models to vision-language models. However, existing methods rely on oversimplified pairwise comparisons, generating a single negative image via basic…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Xintong Li , Chuhan Wang , Junda Wu , Rohan Surana , Tong Yu , Julian McAuley , Jingbo Shang

Large-scale text-to-image foundation models have achieved remarkable visual realism, yet generating human images with correct anatomical structures remains challenging. Existing approaches enforce anatomical constraints through…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Bao Li , Yuliang Xiu , Zhen Liu

In recent years, the field of image generation has witnessed significant advancements, particularly in fine-tuning methods that align models with universal human preferences. This paper explores the critical role of preference data in the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Lingfan Zhang , Chen Liu , Chengming Xu , Kai Hu , Donghao Luo , Chengjie Wang , Yanwei Fu , Yuan Yao

The Segment Anything Model (SAM), a foundation model for general image segmentation, has demonstrated impressive zero-shot performance across numerous natural image segmentation tasks. However, SAM's performance significantly declines when…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Cheng Chen , Juzheng Miao , Dufan Wu , Zhiling Yan , Sekeun Kim , Jiang Hu , Aoxiao Zhong , Zhengliang Liu , Lichao Sun , Xiang Li , Tianming Liu , Pheng-Ann Heng , Quanzheng Li

Medical image segmentation methods generally assume that the process from medical image to segmentation is unbiased, and use neural networks to establish conditional probability models to complete the segmentation task. This assumption does…

Image and Video Processing · Electrical Eng. & Systems 2025-05-29 Ruiguo Yu , Yiyang Zhang , Yuan Tian , Yujie Diao , Di Jin , Witold Pedrycz

Modern preference alignment methods, such as DPO, rely on divergence regularization to a reference model for training stability-but this creates a fundamental problem we call "reference mismatch." In this paper, we investigate the negative…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Jiwoo Hong , Sayak Paul , Noah Lee , Kashif Rasul , James Thorne , Jongheon Jeong

Aligning large-scale text-to-image diffusion models with nuanced human preferences remains challenging. While direct preference optimization (DPO) is simple and effective, large-scale finetuning often shows a generalization gap. We take…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Zhou Jiang , Yandong Wen , Zhen Liu

Direct alignment methods typically train large language models (LLMs) by contrasting the likelihoods of preferred and dispreferred responses. While effective at capturing relative preferences, these methods are widely observed to suppress…

Computation and Language · Computer Science 2025-12-04 Kaiyang Guo , Yinchuan Li , Zhitang Chen