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Biological systems are non-linear, include unobserved variables and the physical principles that govern their dynamics are partly unknown. This makes the characterization of their behavior very challenging. Notably, their activity occurs on…

Quantitative Methods · Quantitative Biology 2025-06-27 Andréa Ducos , Audrey Denizot , Thomas Guyet , Hugues Berry

Spatial reaction-diffusion models have been employed to describe many emergent phenomena in biological systems. The modelling technique most commonly adopted in the literature implements systems of partial differential equations (PDEs),…

Quantitative Methods · Quantitative Biology 2015-10-05 Christian A. Yates , Mark B. Flegg

Non-equilibrium thermodynamics has long been an area of substantial interest to ecologists because most fundamental biological processes, such as protein synthesis and respiration, are inherently energy-consuming. Microbial communities are…

Populations and Evolution · Quantitative Biology 2022-01-19 Jacob Cook , Samraat Pawar , Robert G. Endres

This paper proposes a mathematical model for replicating a simple dynamics in an aquarium with two components; bacteria and organic matter. The model is based on a system of partial differential equations (PDEs) with four components: the…

Analysis of PDEs · Mathematics 2024-01-23 Ken Furukawa , Hiroyuki Kitahata

This paper introduces a novel hybrid model combining Partial Differential Equations (PDEs) and Ordinary Differential Equations (ODEs) to simulate infectious disease dynamics across geographic regions. By leveraging the spatial detail of…

Dynamical Systems · Mathematics 2025-11-18 Kristina Kehrer , Martin Weiser , Tim Conrad

Microbial ecosystems are remarkably diverse, stable, and often consist of a balanced mixture of core and peripheral species. Here we propose a conceptual model exhibiting all these emergent properties in quantitative agreement with real…

Populations and Evolution · Quantitative Biology 2018-04-18 Akshit Goyal , Sergei Maslov

Deriving emergent patterns from models of biological processes is a core concern of mathematical biology. In the context of partial differential equations (PDEs), these emergent patterns sometimes appear as local minimisers of a…

Analysis of PDEs · Mathematics 2022-10-05 Valeria Giunta , Thomas Hillen , Mark A. Lewis , Jonathan R. Potts

Dynamical systems containing heteroclinic cycles and networks can be invoked as models of intransitive competition between three or more species. When populations are assumed to be well-mixed, a system of ordinary differential equations…

Dynamical Systems · Mathematics 2023-11-01 David C Groothuizen Dijkema , Claire M Postlethwaite

A fundamental challenge in microbial ecology is determining whether bacteria compete or cooperate in different environmental conditions. With recent advances in genome-scale metabolic models, we are now capable of simulating interactions…

Quantitative Methods · Quantitative Biology 2025-09-03 Oleksandr Cherendichenko , Josephine Solowiej-Wedderburn , Laura M. Carroll , Eric Libby

We present a data-driven framework for learning hydrodynamic equations from particle-based simulations of active matter. Our method leverages coarse-graining in both space and time to bridge microscopic particle dynamics with macroscopic…

Soft Condensed Matter · Physics 2026-02-18 Bappaditya Roy , Natsuhiko Yoshinaga

This work proposes stochastic partial differential equations (SPDEs) as a practical tool to replicate clustering effects of more detailed particle-based dynamics. Inspired by membrane-mediated receptor dynamics on cell surfaces, we…

Quantitative Methods · Quantitative Biology 2025-01-22 Nathalie Wehlitz , Mohsen Sadeghi , Alberto Montefusco , Christof Schütte , Grigorios A. Pavliotis , Stefanie Winkelmann

Age-structured models capture the dynamic behavior of populations over time and result in nonlinear integro-partial differential equations (IPDEs). These processes arise in various fields such as biotechnology, economics, or demography.…

Systems and Control · Electrical Eng. & Systems 2025-12-08 Carina Veil , Miroslav Krstić , Patrick McNamee , Oliver Sawodny

Bacteria possess diverse mechanisms to regulate their motility in response to environmental and physiological signals, enabling them to navigate complex habitats and adapt their behavior. Among these mechanisms, interspecies recognition…

Populations and Evolution · Quantitative Biology 2025-12-01 Mattia Mattei , David Soriano Paños , Mahantesh Halappanavar , Alex Arenas

This study investigates the role of spatial segregation, prompted by competition avoidance, as a key mechanism for emergent coexistence within microbial communities. Recognizing these communities as complex adaptive systems, we challenge…

Physics and Society · Physics 2024-03-12 Mattia Mattei , Alex Arenas

Aggregation-diffusion equations are foundational tools for modelling biological aggregations. Their principal use is to link the collective movement mechanisms of organisms to their emergent space use patterns in a concrete mathematical…

Populations and Evolution · Quantitative Biology 2025-04-16 Jonathan R. Potts

Microbial ecosystems are commonly modeled by fixed interactions between species in steady exponential growth states. However, microbes often modify their environments so strongly that they are forced out of the exponential state into…

Populations and Evolution · Quantitative Biology 2024-01-08 Avaneesh V. Narla , Terence Hwa , Arvind Murugan

From tumour invasion to cell sorting and animal territoriality, many biological systems rely on nonlocal interactions that drive complex spatial organisation. Partial differential equations (PDEs) with nonlocal advection are increasingly…

Populations and Evolution · Quantitative Biology 2025-06-03 Valeria Giunta , Thomas Hillen , Mark A. Lewis , Jonathan R. Potts

Navigation of microorganisms is controlled by internal processes ultimately sensitive to mechanical or chemical signaling encountered along the path. In many natural environments, such as porous soils or physiological ducts, motile species…

The aim of this paper is to study a PDE model for two diffusing species interacting by local size exclusion and global attraction. This leads to a nonlinear degenerate cross-diffusion system, for which we provide a global existence result.…

Analysis of PDEs · Mathematics 2017-03-21 Judith Berendsen , Martin Burger , Jan-Frederik Pietschmann

The segregation of plasmids in a bacterial population is investigated. Hereby, a dynamical model is formulated in terms of a size-structured population using a hyperbolic partial differential equation incorporating non-local terms (the…

Populations and Evolution · Quantitative Biology 2017-01-13 Johannes Müller , Karin Münch , Bendix Koopmann , Eva Stadler , Louisa Roselius , Dieter Jahn , Richard Münch
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