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Electron Cryo-Tomography (ECT) enables 3D visualization of macromolecule structure inside single cells. Macromolecule classification approaches based on convolutional neural networks (CNN) were developed to separate millions of…

Quantitative Methods · Quantitative Biology 2018-03-28 Jialiang Guo , Bo Zhou , Xiangrui Zeng , Zachary Freyberg , Min Xu

Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of proteins and other macromolecular complexes at near-atomic resolution. In single particle cryo-EM, the central problem is to reconstruct the…

Quantitative Methods · Quantitative Biology 2020-02-18 Ellen D. Zhong , Tristan Bepler , Joseph H. Davis , Bonnie Berger

Implicit Neural Representations (INRs) are increasingly recognized as a versatile data modality for representing discretized signals, offering benefits such as infinite query resolution and reduced storage requirements. Existing signal…

Machine Learning · Computer Science 2025-03-26 Dhananjaya Jayasundara , Sudarshan Rajagopalan , Yasiru Ranasinghe , Trac D. Tran , Vishal M. Patel

Cryo-electron tomography (Cryo-ET) is a powerful tool in structural biology for 3D visualization of cells and biological systems at resolutions sufficient to identify individual proteins in situ. The measurements are collected by tilting…

Signal Processing · Electrical Eng. & Systems 2025-09-03 Vinith Kishore , Valentin Debarnot , AmirEhsan Khorashadizadeh , Ivan Dokmanić

Implicit Neural Representations (INRs) are widely used to encode data as continuous functions, enabling the visualization of large-scale multivariate scientific simulation data with reduced memory usage. However, existing INR-based methods…

Computer Vision and Pattern Recognition · Computer Science 2026-03-04 Hyunsoo Son , Jeonghyun Noh , Suemin Jeon , Chaoli Wang , Won-Ki Jeong

Deep Learning (DL) methods can reconstruct highly accelerated magnetic resonance imaging (MRI) scans, but they rely on application-specific large training datasets and often generalize poorly to out-of-distribution data. Self-supervised…

Image and Video Processing · Electrical Eng. & Systems 2026-04-24 Hongze Yu , Jeffrey A. Fessler , Yun Jiang

Deep neural networks (DNNs) have been quite successful in solving many complex learning problems. However, DNNs tend to have a large number of learning parameters, leading to a large memory and computation requirement. In this paper, we…

Machine Learning · Computer Science 2019-05-21 Sangkyun Lee , Jeonghyun Lee

Cryo-electron tomography (cryoET) is a technique that captures images of biological samples at different tilts, preserving their native state as much as possible. Along with the partial tilt series and noise, one of the major challenges in…

Signal Processing · Electrical Eng. & Systems 2023-07-26 Vinith Kishore , Valentin Debarnot , Ivan Dokmanić

Cryo-electron microscopy (cryo-EM) is an indispensable technique for determining the 3D structures of dynamic biomolecular complexes. While typically applied to image a single molecular species, cryo-EM has the potential for structure…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Jeffrey Gu , Minkyu Jeon , Ambri Ma , Serena Yeung-Levy , Ellen D. Zhong

Cryo-electron microscopy (cryo-EM) enables the atomic-resolution visualization of biomolecules; however, modern direct detectors generate data volumes that far exceed the available storage and transfer bandwidth, thereby constraining…

Image and Video Processing · Electrical Eng. & Systems 2026-03-31 Zain Shabeeb , Daniel Saeedi , Darin Tsui , Vida Jamali , Amirali Aghazadeh

Cryo-electron microscopy (cryo-EM) has become a major experimental technique to determine the structures of large protein complexes and molecular assemblies, as evidenced by the 2017 Nobel Prize. Although cryo-EM has been drastically…

Biomolecules · Quantitative Biology 2021-06-01 Dong Si , Andrew Nakamura , Runbang Tang , Haowen Guan , Jie Hou , Ammaar Firozi , Renzhi Cao , Kyle Hippe , Minglei Zhao

In this paper, we present a joint compression and classification approach of EEG and EMG signals using a deep learning approach. Specifically, we build our system based on the deep autoencoder architecture which is designed not only to…

Machine Learning · Computer Science 2017-03-28 Ahmed Ben Said , Amr Mohamed , Tarek Elfouly , Khaled Harras , Z. Jane Wang

Advances in imagery at atomic and near-atomic resolution, such as cryogenic electron microscopy (cryo-EM), have led to an influx of high resolution images of proteins and other macromolecular structures to data banks worldwide. Producing a…

Quantitative Methods · Quantitative Biology 2021-04-06 Nathan Ranno , Dong Si

In an era where the exponential growth of image data driven by the Internet of Things (IoT) is outpacing traditional storage solutions, this work explores and advances the potential of Implicit Neural Representation (INR) as a…

Image and Video Processing · Electrical Eng. & Systems 2024-09-23 Sai Sanjeet , Seyyedali Hosseinalipour , Jinjun Xiong , Masahiro Fujita , Bibhu Datta Sahoo

Compression and reconstruction of visual data have been widely studied in the computer vision community, even before the popularization of deep learning. More recently, some have used deep learning to improve or refine existing pipelines,…

Computer Vision and Pattern Recognition · Computer Science 2022-11-21 Hao Chen , Matt Gwilliam , Bo He , Ser-Nam Lim , Abhinav Shrivastava

Cellular Electron Cryo-Tomography (CECT) is a powerful imaging technique for the 3D visualization of cellular structure and organization at submolecular resolution. It enables analyzing the native structures of macromolecular complexes and…

Quantitative Methods · Quantitative Biology 2018-05-16 Chang Liu , Xiangrui Zeng , Ruogu Lin , Xiaodan Liang , Zachary Freyberg , Eric Xing , Min Xu

Cryo-electron microscopy (cryo-EM) has become a tool of fundamental importance in structural biology, helping us understand the basic building blocks of life. The algorithmic challenge of cryo-EM is to jointly estimate the unknown 3D poses…

Computer Vision and Pattern Recognition · Computer Science 2022-09-01 Axel Levy , Frédéric Poitevin , Julien Martel , Youssef Nashed , Ariana Peck , Nina Miolane , Daniel Ratner , Mike Dunne , Gordon Wetzstein

Large Deep Neural Networks (DNNs) are the backbone of today's artificial intelligence due to their ability to make accurate predictions when being trained on huge datasets. With advancing technologies, such as the Internet of Things,…

Machine Learning · Computer Science 2023-07-14 Mark Deutel , Philipp Woller , Christopher Mutschler , Jürgen Teich

The past decade's "cryoEM revolution" has produced exponential growth in high-resolution structural data through advances in cryogenic electron microscopy (cryoEM) and tomography (cryoET). Deep learning integration into structural…

Quantitative Methods · Quantitative Biology 2025-07-29 Brady K. Zhou , Jason J. Hu , Jane K. J. Lee , Z. Hong Zhou , Demetri Terzopoulos

For decades, video compression technology has been a prominent research area. Traditional hybrid video compression framework and end-to-end frameworks continue to explore various intra- and inter-frame reference and prediction strategies…

Image and Video Processing · Electrical Eng. & Systems 2024-10-04 Gai Zhang , Xinfeng Zhang , Lv Tang , Yue Li , Kai Zhang , Li Zhang