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Accelerating the discovery of mechanical properties in combinatorial materials requires autonomous experimentation that accounts for both instrument behavior and experimental cost. Here, an automated nanoindentation (AE-NI) framework is…

Materials Science · Physics 2025-11-24 Vivek Chawla , Stephen Puplampu , Haochen Zhu , Philip D. Rack , Dayakar Penumadu , Sergei Kalinin

The real-world implementation of materials prediction algorithms remains limited by persistent characterization bottlenecks in materials discovery, where photon-based probe techniques (e.g., XRD or Raman) impose long acquisition times and…

High-throughput experimentation enables efficient search space exploration for the discovery and optimization of new materials. However, large search spaces of, e.g., compositionally complex materials, require decreasing characterization…

Materials Science · Physics 2023-07-03 Felix Thelen , Lars Banko , Rico Zehl , Sabrina Baha , Alfred Ludwig

Nanoindentation is vital for probing mechanical properties, yet traditional grid-based workflows are inefficient for targeting specific microstructural features. We present an automated nanoindentation framework that integrates machine…

Instrumentation and Detectors · Physics 2025-04-28 Vivek Chawla , Dayakar Penumadu , Sergei Kalinin

In this study, Cu-Cr composites were studied by nanoindentation. Arrays of indents were placed over large areas of the samples resulting in datasets consisting of several hundred measurements of Young's modulus and hardness at varying…

Machine Learning · Computer Science 2023-09-14 Chen Zhang , Clémence Bos , Stefan Sandfeld , Ruth Schwaiger

Ultra-large make-on-demand compound libraries now contain billions of readily available compounds. This represents a golden opportunity for in-silico drug discovery. One challenge, however, is the time and computational cost of an…

Quantitative Methods · Quantitative Biology 2025-12-10 Paul Eisenhuth , Fabian Liessmann , Rocco Moretti , Jens Meiler

The current bulk materials discovery cycle has several inefficiencies from initial computational predictions through fabrication and analyses. Materials are generally evaluated in a singular fashion, relying largely on human-driven…

Materials Science · Physics 2021-02-12 Olivia F. Dippo , Kevin R. Kaufmann , Kenneth S. Vecchio

Indentation test is used with growing popularity for the characterization of various materials on different scales. Developed methods are combining the test with computer simulation and inverse analyses to assess material parameters…

Computational Physics · Physics 2015-07-14 Vladimir Buljak , Shwetank Pandey

A method is presented for the registration and correlation of intrinsic property maps of materials, including data from nanoindentation hardness, Electron Back-Scattered Diffraction (EBSD), Electron Micro-Probe Analysis (EPMA). This highly…

Materials Science · Physics 2021-01-05 C. M. Magazzeni , H. M. Gardner , I. Howe , P. Gopon , J. C. Waite , D. Rugg , D. E. J. Armstrong , A. J. Wilkinson

High entropy alloys offer a huge search space for new electrocatalysts. Searching for a global property maximum in one quinary system could require, depending on compositional resolution, the synthesis of up to 10E6 samples which is…

Combinatorial materials libraries provide a powerful platform for mapping how physical properties evolve across binary and ternary cross-sections of multicomponent phase diagrams. While synthesis of such libraries has advanced since the…

Multi-principal element alloys open large composition spaces for alloy development. The large compositional space necessitates rapid synthesis and characterization to identify promising materials, as well as predictive strategies for alloy…

The discovery and optimization of materials for specific applications is hampered by the practically infinite number of possible elemental combinations and associated properties, also known as the `combinatorial explosion'. By nature of the…

Computation and Language · Computer Science 2025-06-11 Lei Zhang , Markus Stricker

We present a new paradigm for speeding up randomized computations of several frequently used functions in machine learning. In particular, our paradigm can be applied for improving computations of kernels based on random embeddings. Above…

Machine Learning · Statistics 2016-04-26 Krzysztof Choromanski , Francois Fagan

A thorough in situ characterization of materials at extreme conditions is challenging, and computational tools such as crystal structural search methods in combination with ab initio calculations are widely used to guide experiments by…

Materials Science · Physics 2018-11-14 Maximilian Amsler , Vinay I. Hegde , Steven D. Jacobsen , Chris Wolverton

As the need for miniaturized structural and functional materials has increased,the need for precise materials characterizaton has also expanded. Nanoindentation is a popular method that can be used to measure material mechanical behavior…

Materials discovery is a computationally intensive process that requires exploring vast chemical spaces to identify promising candidates with desirable properties. In this work, we propose using quantum-enhanced machine learning algorithms…

This study presents a computationally efficient framework for accelerated alloy discovery that uses the non-interacting electron density to capture intrinsic structure-property relationships in refractory high-entropy alloys (HEAs). Unlike…

Materials Science · Physics 2026-04-28 Pranoy Ray , Sayan Bhowmik , Phanish Suryanarayana , Surya R. Kalidindi , Andrew J. Medford

Automatic design of organic materials requires black-box optimization in a vast chemical space. In conventional molecular design algorithms, a molecule is built as a combination of predetermined fragments. Recently, deep neural network…

Chemical Physics · Physics 2018-06-27 Xiufeng Yang , Jinzhe Zhang , Kazuki Yoshizoe , Kei Terayama , Koji Tsuda

Computational materials science increasingly benefits from data management, automation, and algorithm-based decision-making for the simulation of material properties and behavior. Experimental materials science also changes rapidly by…

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