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Nanopore resistive pulse sensors are emerging technologies for single-molecule protein sequencing. But they can hardly detect small post-translational modifications (PTMs) such as hydroxylation in single-molecule level. While a combination…

Quantitative Methods · Quantitative Biology 2024-01-09 Mulusew W. Yaltaye , Yingqi Zhao , Eva Bozo , Pei-Lin Xin , Vahid Farrah , Francesco De Angelis , Jian-An Huang

Surface lattice resonances (SLRs) in metasurfaces have become a transformative platform for subwavelength optical devices, leveraging their high quality (Q)-factors, pronounced local field enhancement, and extensive long-range interactions.…

Next generation wound care technology capable of diagnosing wound parameters, promoting healthy cell growth and reducing pathogenic infections noninvasively will provide patients with an improved standard of care and an accelerated wound…

Label-free vibrational imaging by stimulated Raman scattering (SRS) provides unprecedented insight into real-time chemical distributions in living systems. Specifically, SRS in the fingerprint region can resolve multiple chemicals in a…

In tissue engineering, we seek to address comprehensive tissue repair and regeneration needs. Aligned nanofibers have emerged as powerful and versatile tools, attributable to their structural and biochemical congruence with the natural…

Medical Physics · Physics 2024-08-16 Gayatri Patel , Louis-S. Bouchard

Currently the extent of nanoplastic in the environment can only be estimated by extrapolation from the plastic waste that can be detected. To be able to quantify the whole extent of the problem, detection methods have to be developed that…

Optics · Physics 2025-11-12 Ambika Shorny , Fritz Steiner , Helmut Hörner , Sarah M. Skoff

Surface-enhanced spectroscopy techniques are the method-of-choice to characterize adsorbed intermediates occurring during electrochemical reactions, which are crucial in realizing a green sustainable future. Characterizing species with low…

Mesoscale and Nanoscale Physics · Physics 2023-07-21 Malo Duportal , Luca M. Berger , Stefan A. Maier , Andreas Tittl , Katharina Krischer

Deterministic fractal antennas are employed to realize multimodal plasmonic devices. Such structures show strongly enhanced localized electromagnetic fields typically in the infrared range with a hierarchical spatial distribution.…

The continuous development of new multiphase alloys with improved mechanical properties requires quantitative microstructure-resolved observation of the nanoscale deformation mechanisms at, e.g., multiphase interfaces. This calls for a…

Mass spectrometry of intact nanoparticles and viruses can serve as a potent characterization tool for material science and biophysics. Inaccessible by widespread commercial techniques, the mass of single nanoparticles and viruses (>10MDa)…

Surface-enhanced Raman spectroscopy (SERS) using gold-nanorod-dimer nanoantennas has shown great potential in various applications. This reflects in their large values of the customary figure of merit of SERS: the enhancement factor (EF),…

Surface enhanced Raman spectroscopy, is a technique of fundamental importance to analytical science and technology where the amplified Raman spectrum of analytes is used for chemical fingerprinting. Here, we showcase an engineered…

Applied Physics · Physics 2021-06-08 K N Prajapati , Anoop A Nair , S Ravi P Silva , J Mitra

This paper investigates multiuser multi-input single-output downlink symbiotic radio communication systems assisted by an intelligent reflecting surface (IRS). Different from existing methods ideally assuming the secondary user (SU) can…

Information Theory · Computer Science 2021-10-22 Shaokang Hu , Chang Liu , Zhiqiang Wei , Yuanxin Cai , Derrick Wing Kwan Ng , Jinhong Yuan

While electron microscopy offers crucial atomic-resolution insights into structure-property relationships, radiation damage severely limits its use on beam-sensitive materials like proteins and 2D materials. To overcome this challenge, we…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Zifei Wang , Zian Mao , Xiaoya He , Xi Huang , Haoran Zhang , Chun Cheng , Shufen Chu , Tingzheng Hou , Xiaoqin Zeng , Yujun Xie

Plasmon-enhanced chemical transformations at the solid-liquid interface can be imaged with high sensitivity, chemical selectivity, and nanoscale precision through tip-enhanced Raman scattering (TERS). We demonstrate the latter for the first…

Chemical Physics · Physics 2019-03-29 Ashish Bhattarai , Patrick Z. El-Khoury

We present a general model study of surface-enhanced resonant Raman scattering and fluorescence, focusing on the interplay between electromagnetic (EM) effects and the molecular dynamics as treated by a density matrix calculation. The model…

Other Condensed Matter · Physics 2007-05-23 Peter Johansson , Hongxing Xu , Mikael Käll , ;

Four-dimensional scanning transmission electron microscopy (4D-STEM) is a powerful tool that allows for the simultaneous acquisition of spatial and diffraction information, driven by recent advancements in direct electron detector…

Materials Science · Physics 2024-10-23 Ujjval Bansal , Amit Sharma , Barbara Putz , Christoph Kirchlechner , Subin Lee

We demonstrate fast (0.25 s/pixel) nanoscale chemical imaging in aqueous solution via tip-enhanced Raman scattering (TERS), with sub-15 nm spatial resolution. The substrate consists of 4-mercaptobenzonitrile-functionalized monocrystalline…

Chemical Physics · Physics 2019-03-11 Ashish Bhattarai , Alan G. Joly , Andrey Krayev , Patrick Z. El-Khoury

The vibrational landscape of adsorbed molecules is central to understanding surface interactions at the atomic scale, influencing phenomena from catalysis to molecular electronics. Recent advances in atomic-scale tip-enhanced Raman…

We present a compact, noise-resilient reconstructive spectrometer-on-a-chip that achieves high-resolution hyperspectral imaging across an extended near-infrared (NIR) range up to 1100nm. The device integrates monolithically fabricated…

Optics · Physics 2025-08-26 Ahasan Ahamed , Htet Myat , Amita Rawat , Lisa N McPhillips , M Saif Islam