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An open question in systems and computational neuroscience is how neural circuits accumulate evidence towards a decision. Fitting models of decision-making theory to neural activity helps answer this question, but current approaches limit…

Neurons and Cognition · Quantitative Biology 2020-01-15 David M. Zoltowski , Jonathan W. Pillow , Scott W. Linderman

Diffusion models are important in tissue engineering as they enable an understanding of molecular delivery to cells in tissue constructs. As three-dimensional (3D) tissue constructs become larger, more intricate, and more clinically…

Tissues and Organs · Quantitative Biology 2015-12-22 Richard J. McMurtrey

We consider potential type dynamical systems in finite dimensions with two meta-stable states. They are subject to two sources of perturbation: a slow external periodic perturbation of period $T$ and a small Gaussian random perturbation of…

Probability · Mathematics 2007-05-23 Samuel Herrmann , Peter Imkeller , Dierk Peithmann

Reaction-diffusion models are used to describe systems in fields as diverse as physics, chemistry, ecology and biology. The fundamental quantities in such models are individual entities such as atoms and molecules, bacteria, cells or…

Computational Physics · Physics 2016-03-02 Fabian Spill , Pilar Guerrero , Tomas Alarcon , Philip K. Maini , Helen Byrne

We develop a diagrammatic scattering theory for interacting bosons in a three-dimensional, weakly disordered potential. Based on a microscopic N-body scattering theory, we identify the relevant diagrams including elastic and inelastic…

Quantum Physics · Physics 2015-06-16 Tobias Geiger , Andreas Buchleitner , Thomas Wellens

We investigate theoretically the stochastic dynamics of Resonance Electronic Energy Transfer (RET), in a bi-dimensional overexcited ensemble of donor and acceptor molecules. We find that, after initial optical excitation of all the donors,…

Mesoscale and Nanoscale Physics · Physics 2023-11-27 R. Avriller , A. Marché , G. Jonusauskas

The reaction-diffusion models have been extensively applied to explain the mechanism of pattern formations in early embryogenesis based on geometrically confined microtissues consisting of human pluripotent stem cells. Recently, mechanical…

Biological Physics · Physics 2022-11-22 Tiankai Zhao , Hongyan Yuan

We study an ensemble of random walkers carrying internal noisy phase oscillators which are synchronized among the walkers by local interactions. Due to individual mobility, the interaction partners of every walker change randomly, hereby…

Statistical Mechanics · Physics 2016-05-04 Robert Großmann , Fernando Peruani , Markus Bär

The interactions between diffusing molecules and membrane-bound receptors drive numerous cellular processes. In this work, we develop a spatial model of molecular interactions with membrane receptors by homogenizing the cell membrane and…

Quantitative Methods · Quantitative Biology 2025-01-24 Anil Cengiz , Sean D Lawley

In a series of two papers, we investigate the large deviations and asymptotic behavior of stochastic models of brain neural networks with random interaction coefficients. In this first paper, we take into account the spatial structure of…

Probability · Mathematics 2017-01-05 Tanguy Cabana , Jonathan Touboul

Understanding how species persist under interacting stressors is a central challenge in ecology. We develop a spatially explicit reaction-diffusion framework to investigate competing species in landscapes shaped by climate variability,…

Populations and Evolution · Quantitative Biology 2026-02-02 Ton Viet Ta

Self-organized structures in networks with spike-timing dependent plasticity (STDP) are likely to play a central role for information processing in the brain. In the present study we derive a reaction-diffusion-like formalism for plastic…

Disordered Systems and Neural Networks · Physics 2016-06-15 Dmytro Grytskyy , Markus Diesmann , Moritz Helias

Chemical reactions inside cells are generally considered to happen within fixed-size compartments. Needless to say, cells and their compartments are highly dynamic. Thus, such stringent assumptions may not reflect biochemical reality, and…

Quantitative Methods · Quantitative Biology 2016-02-17 Atiyo Ghosh , Tatiana T. Marquez-Lago

Dynamical systems theory provides powerful methods to extract effective macroscopic dynamics from complex systems with slow modes and fast modes. Here we derive and theoretically support a macroscopic, spatially discrete, model for a class…

Analysis of PDEs · Mathematics 2010-03-12 Wei Wang , A. J. Roberts

Nonlinear reaction-diffusion systems admit a wide variety of spatiotemporal patterns or structures. In this lecture, we point out that there is certain advantage in studying discrete arrays, namely cellular neural/nonlinear networks (CNNs),…

Pattern Formation and Solitons · Physics 2007-05-23 M. Lakshmanan , P. Muruganandam

We examine characteristic properties of deterministic and stochastic diffusion in low-dimensional chaotic dynamical systems. As an example, we consider a periodic array of scatterers defined by a simple chaotic map on the line. Adding…

Chaotic Dynamics · Physics 2009-11-07 R. Klages

Neurons in the brain communicate with spikes, which are discrete events in time and value. Functional network models often employ rate units that are continuously coupled by analog signals. Is there a qualitative difference implied by these…

Disordered Systems and Neural Networks · Physics 2021-07-20 Christian Keup , Tobias Kühn , David Dahmen , Moritz Helias

Microcirculation of blood and oxygen transport play important roles in biological function of optic nerve and are directly affected by damages or pathologies. This work develops a multi-domain model for optic nerve, that includes important…

Biological Physics · Physics 2024-01-18 Zilong Song , Shixin Xu , Robert Eisenberg , Huaxiong Huang

The lateral diffusion and trapping of protein receptors within the postsynaptic membrane of a neuron plays a key role in determining the strength of synaptic connections and their regulation during learning and memory. In this paper we…

Statistical Mechanics · Physics 2023-07-19 Paul C Bressloff

Reaction diffusion equations have been used to model a wide range of biological phenomenon related to population spread and proliferation from ecology to cancer. It is commonly assumed that individuals in a population have homogeneous…

Dynamical Systems · Mathematics 2023-04-14 Kyle Nguyen , Erica M. Rutter , Kevin Flores