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Cell type identification from single-cell transcriptomic data is a common goal of single-cell RNA sequencing (scRNAseq) data analysis. Neural networks have been employed to identify cell types from scRNAseq data with high performance.…

Genomics · Quantitative Biology 2020-05-11 Xishuang Dong , Shanta Chowdhury , Uboho Victor , Xiangfang Li , Lijun Qian

This paper presents Prototypical Contrastive Learning (PCL), an unsupervised representation learning method that addresses the fundamental limitations of instance-wise contrastive learning. PCL not only learns low-level features for the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Junnan Li , Pan Zhou , Caiming Xiong , Steven C. H. Hoi

Contrastive learning (CL) methods effectively learn data representations in a self-supervision manner, where the encoder contrasts each positive sample over multiple negative samples via a one-vs-many softmax cross-entropy loss. By…

Machine Learning · Computer Science 2023-08-16 Huangjie Zheng , Xu Chen , Jiangchao Yao , Hongxia Yang , Chunyuan Li , Ya Zhang , Hao Zhang , Ivor Tsang , Jingren Zhou , Mingyuan Zhou

Self-Supervised Contrastive Learning has proven effective in deriving high-quality representations from unlabeled data. However, a major challenge that hinders both unimodal and multimodal contrastive learning is feature suppression, a…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Jihai Zhang , Xiang Lan , Xiaoye Qu , Yu Cheng , Mengling Feng , Bryan Hooi

Identifying unique characteristics in a network through comparison with another network is an essential network analysis task. For example, with networks of protein interactions obtained from normal and cancer tissues, we can discover…

Machine Learning · Computer Science 2022-02-16 Takanori Fujiwara , Jian Zhao , Francine Chen , Yaoliang Yu , Kwan-Liu Ma

The swift advancement of single-cell RNA sequencing (scRNA-seq) technologies enables the investigation of cellular-level tissue heterogeneity. Cell annotation significantly contributes to the extensive downstream analysis of scRNA-seq data.…

Machine Learning · Computer Science 2024-11-28 Huifa Li , Jie Fu , Xinpeng Ling , Zhiyu Sun , Kuncan Wang , Zhili Chen

Anomaly detection aims at identifying deviant samples from the normal data distribution. Contrastive learning has provided a successful way to sample representation that enables effective discrimination on anomalies. However, when…

Computer Vision and Pattern Recognition · Computer Science 2022-07-26 Gaoang Wang , Yibing Zhan , Xinchao Wang , Mingli Song , Klara Nahrstedt

Recently, various contrastive learning techniques have been developed to categorize time series data and exhibit promising performance. A general paradigm is to utilize appropriate augmentations and construct feasible positive samples such…

Machine Learning · Computer Science 2024-10-11 Qianying Ren , Dongsheng Luo , Dongjin Song

Disease diagnosis from medical images via supervised learning is usually dependent on tedious, error-prone, and costly image labeling by medical experts. Alternatively, semi-supervised learning and self-supervised learning offer…

Computer Vision and Pattern Recognition · Computer Science 2023-06-14 Attiano Purpura-Pontoniere , Demetri Terzopoulos , Adam Wang , Abdullah-Al-Zubaer Imran

Contrastive learning has gained significant attention in short text clustering, yet it has an inherent drawback of mistakenly identifying samples from the same category as negatives and then separating them in the feature space (false…

Machine Learning · Computer Science 2026-03-16 Zhihao Yao

While contrastive learning is proven to be an effective training strategy in computer vision, Natural Language Processing (NLP) is only recently adopting it as a self-supervised alternative to Masked Language Modeling (MLM) for improving…

Computation and Language · Computer Science 2021-09-16 Hooman Sedghamiz , Shivam Raval , Enrico Santus , Tuka Alhanai , Mohammad Ghassemi

Unsupervised out-of-distribution (OOD) Detection aims to separate the samples falling outside the distribution of training data without label information. Among numerous branches, contrastive learning has shown its excellent capability of…

Computer Vision and Pattern Recognition · Computer Science 2023-02-07 Menglong Chen , Xingtai Gui , Shicai Fan

Conformal inference is a method that provides prediction sets for machine learning models, operating independently of the underlying distributional assumptions and relying solely on the exchangeability of training and test data. Despite its…

Methodology · Statistics 2025-10-01 Daniela Corbetta , Livio Finos , Ludwig Geistlinger , Davide Risso

Contrastive self-supervised learning (SSL) learns an embedding space that maps similar data pairs closer and dissimilar data pairs farther apart. Despite its success, one issue has been overlooked: the fairness aspect of representations…

Contrastive representation learning (CRL) underpins many modern foundation models. Despite recent theoretical progress, existing analyses suffer from several key limitations: (i) the statistical consistency of CRL remains poorly understood;…

Machine Learning · Computer Science 2026-05-29 Yuanfan Li , Xiyuan Wei , Tianbao Yang , Yiming Ying

This paper presents SimCLR: a simple framework for contrastive learning of visual representations. We simplify recently proposed contrastive self-supervised learning algorithms without requiring specialized architectures or a memory bank.…

Machine Learning · Computer Science 2020-07-02 Ting Chen , Simon Kornblith , Mohammad Norouzi , Geoffrey Hinton

Contrastive Analysis is a sub-field of Representation Learning that aims at separating common factors of variation between two datasets, a background (i.e., healthy subjects) and a target (i.e., diseased subjects), from the salient factors…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Robin Louiset , Edouard Duchesnay , Antoine Grigis , Pietro Gori

The study of cells and their responses to genetic or chemical perturbations promises to accelerate the discovery of therapeutic targets. However, designing adequate and insightful models for such data is difficult because the response of a…

Machine Learning · Computer Science 2024-12-04 Haiyi Mao , Romain Lopez , Kai Liu , Jan-Christian Hütter , David Richmond , Panayiotis V. Benos , Lin Qiu

We propose Graph Contrastive Learning (GraphCL), a general framework for learning node representations in a self supervised manner. GraphCL learns node embeddings by maximizing the similarity between the representations of two randomly…

Machine Learning · Computer Science 2020-07-17 Hakim Hafidi , Mounir Ghogho , Philippe Ciblat , Ananthram Swami

Text classification is a crucial and fundamental task in web content mining. Compared with the previous learning paradigm of pre-training and fine-tuning by cross entropy loss, the recently proposed supervised contrastive learning approach…

Computation and Language · Computer Science 2026-01-26 Mengyu Li , Yonghao Liu , Fausto Giunchiglia , Ximing Li , Xiaoyue Feng , Renchu Guan