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Biological classification with interpretability remains a challenging task. For this, we introduce a novel encoding framework, Multi-Scale Reversible Chaos Game Representation (MS-RCGR), that transforms biological sequences into…

Machine Learning · Computer Science 2026-04-21 Sarwan Ali , Taslim Murad

Accurate molecular sequence analysis is a key task in the field of bioinformatics. To apply molecular sequence classification algorithms, we first need to generate the appropriate representations of the sequences. Traditional numeric…

Machine Learning · Computer Science 2024-12-31 Sarwan Ali , Tamkanat E Ali , Imdad Ullah Khan , Murray Patterson

We present a novel information-preserving Chaos Game Representation (CGR) method, also called Reverse-CGR (R-CGR), for biological sequence analysis that addresses the fundamental limitation of traditional CGR approaches - the loss of…

Machine Learning · Computer Science 2025-09-25 Sarwan Ali

The analysis of sequences (e.g., protein, DNA, and SMILES string) is essential for disease diagnosis, biomaterial engineering, genetic engineering, and drug discovery domains. Conventional analytical methods focus on transforming sequences…

Quantitative Methods · Quantitative Biology 2025-03-20 Taslim Murad , Sarwan Ali , Murray Patterson

Cancer is a complex disease characterized by uncontrolled cell growth. T cell receptors (TCRs), crucial proteins in the immune system, play a key role in recognizing antigens, including those associated with cancer. Recent advancements in…

Machine Learning · Computer Science 2025-06-12 Taslim Murad , Prakash Chourasia , Sarwan Ali , Imdad Ullah Khan , Murray Patterson

Topological correctness plays a critical role in many image segmentation tasks, yet most networks are trained using pixel-wise loss functions, such as Dice, neglecting topological accuracy. Existing topology-aware methods often lack robust…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Laurin Lux , Alexander H. Berger , Alexander Weers , Nico Stucki , Daniel Rueckert , Ulrich Bauer , Johannes C. Paetzold

Convolutional Neural Networks (CNN) has achieved a great success in image recognition task by automatically learning a hierarchical feature representation from raw data. While the majority of Time-Series Classification (TSC) literature is…

Computer Vision and Pattern Recognition · Computer Science 2017-10-10 Nima Hatami , Yann Gavet , Johan Debayle

In this study, we present a method of pattern mining based on network theory that enables the identification of protein structures or complexes from synthetic volume densities, without the knowledge of predefined templates or human biases…

Quantitative Methods · Quantitative Biology 2022-10-18 August George , Doo Nam Kim , Trevor Moser , Ian T. Gildea , James E. Evans , Margaret S. Cheung

Recent advances in molecular representation learning have produced highly effective encodings of molecules for numerous cheminformatics and bioinformatics tasks. However, extracting general chemical insight while balancing predictive…

Machine Learning · Computer Science 2025-09-26 Rahul Khorana

Complex prediction models such as deep learning are the output from fitting machine learning, neural networks, or AI models to a set of training data. These are now standard tools in science. A key challenge with the current generation of…

Machine Learning · Computer Science 2022-10-21 Meng Liu , Tamal K. Dey , David F. Gleich

For several decades, chemical knowledge has been published in written text, and there have been many attempts to make it accessible, for example, by transforming such natural language text to a structured format. Although the discovered…

Computer Vision and Pattern Recognition · Computer Science 2022-02-22 Sanghyun Yoo , Ohyun Kwon , Hoshik Lee

Segmenting curvilinear structures in medical images is essential for analyzing morphological patterns in clinical applications. Integrating topological properties, such as connectivity, improves segmentation accuracy and consistency.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Zhuangzhi Gao , Feixiang Zhou , He Zhao , Xiuju Chen , Xiaoxin Li , Qinkai Yu , Yitian Zhao , Alena Shantsila , Gregory Y. H. Lip , Eduard Shantsila , Yalin Zheng

Sequence data, such as DNA, RNA, and protein sequences, exhibit intricate, multi-scale structures that pose significant challenges for conventional analysis methods, particularly those relying on alignment or purely statistical…

Genomics · Quantitative Biology 2025-10-22 Jian Liu , Li Shen , Mushal Zia , Guo-Wei Wei

Despite the effectiveness of Convolutional Neural Networks (CNNs) for image classification, our understanding of the relationship between shape of convolution kernels and learned representations is limited. In this work, we explore and…

Computer Vision and Pattern Recognition · Computer Science 2016-11-30 Zhun Sun , Mete Ozay , Takayuki Okatani

Recent advances in molecular science have been propelled significantly by large language models (LLMs). However, their effectiveness is limited when relying solely on molecular sequences, which fail to capture the complex structures of…

Quantitative Methods · Quantitative Biology 2025-08-12 Jianting Tang , Yubo Wang , Haoyu Cao , Linli Xu

This paper focuses on the challenging task of learning 3D object surface reconstructions from single RGB images. Existing methods achieve varying degrees of success by using different geometric representations. However, they all have their…

Computer Vision and Pattern Recognition · Computer Science 2019-04-11 Jiapeng Tang , Xiaoguang Han , Junyi Pan , Kui Jia , Xin Tong

Graph neural networks have emerged as a promising paradigm for image processing, yet their performance in image classification tasks is hindered by a limited consideration of the underlying structure and relationships among visual entities.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Usama Zidan , Mohamed Gaber , Mohammed M. Abdelsamea

Graph embeddings play a critical role in graph representation learning, allowing machine learning models to explore and interpret graph-structured data. However, existing methods often rely on opaque, high-dimensional embeddings, limiting…

Machine Learning · Computer Science 2025-11-26 Astrit Tola , Funmilola Mary Taiwo , Cuneyt Gurcan Akcora , Baris Coskunuzer

Sequence classification has a wide range of real-world applications in different domains, such as genome classification in health and anomaly detection in business. However, the lack of explicit features in sequence data makes it difficult…

Machine Learning · Computer Science 2023-06-19 Khaled Mohammed Saifuddin , Corey May , Farhan Tanvir , Muhammad Ifte Khairul Islam , Esra Akbas

Multi-sequence MRIs can be necessary for reliable diagnosis in clinical practice due to the complimentary information within sequences. However, redundant information exists across sequences, which interferes with mining efficient…

Computer Vision and Pattern Recognition · Computer Science 2023-02-02 Luyi Han , Tao Tan , Tianyu Zhang , Yunzhi Huang , Xin Wang , Yuan Gao , Jonas Teuwen , Ritse Mann
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