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Voxel-wise dose prediction is a critical yet challenging task in practical radiotherapy (RT) planning, as bespoke models trained from scratch often struggle to generalize across diverse clinical settings. Meanwhile, generative models…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Yuhan Wang , Zihan Li , Han Liu , Simon Arberet , Martin Kraus , Yuyin Zhou , Florin-Cristian Ghesu , Dorin Comaniciu , Ali Kamen , Riqiang Gao

Inverse design optimization aims to infer system parameters from observed solutions, posing critical challenges across domains such as semiconductor manufacturing, structural engineering, materials science, and fluid dynamics. The lack of…

Artificial Intelligence · Computer Science 2025-10-16 Haoyu Yang , Kamyar Azizzadenesheli , Haoxing Ren

Modern external beam cancer radiotherapy applies prescribed radiation doses to tumor targets while minimally affecting nearby vulnerable organs-at-risk (OARs). Creating a treatment plan is difficult and time-consuming with no guarantee of…

Medical Physics · Physics 2021-07-07 Lyndon Hibbard

Objective: This study aims to uncover the opaque decision-making process of an artificial intelligence (AI) agent for automatic treatment planning. Approach: We examined a previously developed AI agent based on the Actor-Critic with…

Medical Physics · Physics 2025-08-21 Md Mainul Abrar , Xun Jia , Yujie Chi

The advent of Generative AI (GenAI) in education presents a transformative approach to traditional teaching methodologies, which often overlook the diverse needs of individual students. This study introduces a GenAI tool, based on advanced…

Computers and Society · Computer Science 2024-03-20 Kostas Karpouzis , Dimitris Pantazatos , Joanna Taouki , Kalliopi Meli

Customizing robotic behaviors to be aligned with diverse human preferences is an underexplored challenge in the field of embodied AI. In this paper, we present Promptable Behaviors, a novel framework that facilitates efficient…

Computer Vision and Pattern Recognition · Computer Science 2023-12-18 Minyoung Hwang , Luca Weihs , Chanwoo Park , Kimin Lee , Aniruddha Kembhavi , Kiana Ehsani

This work addresses the challenge of personalizing trajectories generated in automated decision-making systems by introducing a resource-efficient approach that enables rapid adaptation to individual users' preferences. Our method leverages…

Machine Learning · Computer Science 2025-03-25 Wen Zheng Terence Ng , Jianda Chen , Yuan Xu , Tianwei Zhang

Diffusion models have made substantial advances in image generation, yet models trained on large, unfiltered datasets often yield outputs misaligned with human preferences. Numerous methods have been proposed to fine-tune pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Fu-Yun Wang , Yunhao Shui , Jingtan Piao , Keqiang Sun , Hongsheng Li

Recent advances in generative artificial intelligence (AI) technologies have been significantly driven by models such as generative adversarial networks (GANs), variational autoencoders (VAEs), and denoising diffusion probabilistic models…

Machine Learning · Computer Science 2024-10-24 Chengyuan Li , Tianyu Zhang , Xusheng Du , Ye Zhang , Haoran Xie

Understanding and predicting the progression of neurodegenerative diseases remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning. However, most available…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Nivetha Jayakumar , Swakshar Deb , Bahram Jafrasteh , Qingyu Zhao , Miaomiao Zhang

There is a growing need for fast and accurate methods for testing developmental neurotoxicity across several chemical exposure sources. Current approaches, such as in vivo animal studies, and assays of animal and human primary cell…

Quantitative Methods · Quantitative Biology 2020-02-26 Finn Kuusisto , Vitor Santos Costa , Zhonggang Hou , James Thomson , David Page , Ron Stewart

Purpose: Several inverse planning algorithms have been developed for Gamma Knife (GK) radiosurgery to determine a large number of plan parameters via solving an optimization problem, which typically consists of multiple objectives. The…

Diffusion models have emerged as powerful tools for 3D medical image generation, yet bridging the gap between standard training objectives and clinical relevance remains a challenge. This paper presents a method to enhance 3D diffusion…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Yueying Tian , Xudong Han , Meng Zhou , Rodrigo Aviles-Espinosa , Rupert Young , Philip Birch

The rational design of molecules with desired properties is a long-standing challenge in chemistry. Generative neural networks have emerged as a powerful approach to sample novel molecules from a learned distribution. Here, we propose a…

We propose generative neural network methods to generate DNA sequences and tune them to have desired properties. We present three approaches: creating synthetic DNA sequences using a generative adversarial network; a DNA-based variant of…

Machine Learning · Computer Science 2017-12-19 Nathan Killoran , Leo J. Lee , Andrew Delong , David Duvenaud , Brendan J. Frey

Preference learning has long been studied in Human-Robot Interaction (HRI) in order to adapt robot behavior to specific user needs and desires. Typically, human preferences are modeled as a scalar function; however, such a formulation…

Robotics · Computer Science 2024-04-01 Austin Narcomey , Nathan Tsoi , Ruta Desai , Marynel Vázquez

Learning models of user behaviour is an important problem that is broadly applicable across many application domains requiring human-robot interaction. In this work we show that it is possible to learn a generative model for distinct user…

Artificial Intelligence · Computer Science 2019-06-25 Daniel Angelov , Yordan Hristov , Subramanian Ramamoorthy

Professional-grade software applications are powerful but complicated$-$expert users can achieve impressive results, but novices often struggle to complete even basic tasks. Photo editing is a prime example: after loading a photo, the user…

Preference tuning is a crucial process for aligning deep generative models with human preferences. This survey offers a thorough overview of recent advancements in preference tuning and the integration of human feedback. The paper is…

Computation and Language · Computer Science 2024-11-05 Genta Indra Winata , Hanyang Zhao , Anirban Das , Wenpin Tang , David D. Yao , Shi-Xiong Zhang , Sambit Sahu

Traditional preference tuning methods for LLMs/Visual Generative Models often rely solely on reward model labeling, which can be opaque, offer limited insights into the rationale behind preferences, and are prone to issues such as reward…

Machine Learning · Computer Science 2026-01-13 Hanyang Zhao , Haoxian Chen , Yucheng Guo , Genta Indra Winata , Tingting Ou , Ziyu Huang , David D. Yao , Wenpin Tang