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Today, intensity-modulated radiation therapy (IMRT) is one of the methods used to treat brain tumors. In conventional treatment planning methods, after identifying planning target volume (PTV), and organs at risk (OARs), and determining the…

Quantitative Methods · Quantitative Biology 2023-05-15 Mobina Naeemi , Mohamad Reza Esmaeili , Iraj Abedi

Conventional radiotherapy dose calculation algorithms are often computationally slow and non-differentiable, creating bottlenecks for online adaptive radiotherapy (ART) and limiting end-to-end automatic planning. Deep learning provides…

This report describes an application of artificial intelligence (AI) to the Bayesian analysis of glioblastoma survival data. It has been suggested that AI can be used to construct prior distributions for parameters in Bayesian models rather…

Applications · Statistics 2025-11-04 Richard Evans , Max Felland , Susanna Evans , Lindsey Sloan

Knowledge-based planning (KBP) is an automated approach to radiation therapy treatment planning that involves predicting desirable treatment plans before they are then corrected to deliverable ones. We propose a generative adversarial…

Machine Learning · Computer Science 2018-07-18 Rafid Mahmood , Aaron Babier , Andrea McNiven , Adam Diamant , Timothy C. Y. Chan

Objective: We propose a semiautomatic pipeline for radiation therapy treatment planning, combining ideas from machine learning-automated planning and multicriteria optimization (MCO). Approach: Using knowledge extracted from historically…

Medical Physics · Physics 2022-02-16 Tianfang Zhang , Rasmus Bokrantz , Jimmy Olsson

The fundamental goal of generative drug design is to propose optimized molecules that meet predefined activity, selectivity, and pharmacokinetic criteria. Despite recent progress, we argue that existing generative methods are limited in…

Chemical Physics · Physics 2020-12-17 Julien Horwood , Emmanuel Noutahi

Artificial Intelligence in healthcare is a new and exciting frontier and the possibilities are endless. With deep learning approaches beating human performances in many areas, the logical next step is to attempt their application in the…

Machine Learning · Computer Science 2018-08-21 Ally Salim

Sequential Recommendation (SR) focuses on personalizing user experiences by predicting future preferences based on historical interactions. Transformer models, with their attention mechanisms, have become the dominant architecture in SR…

Information Retrieval · Computer Science 2025-08-05 Yuli Liu , Wenjun Kong , Cheng Luo , Weizhi Ma

Radiation response in cancer is shaped by complex, patient specific biology, yet current treatment strategies often rely on uniform dose prescriptions without accounting for tumor heterogeneity. In this study, we introduce a meta learning…

Medical Physics · Physics 2025-08-12 Hao Peng , Yuanyuan Zhang , Steve Jiang , Robert Timmerman , John Minna

Deep learning has proven to yield fast and accurate predictions of quantum-chemical properties to accelerate the discovery of novel molecules and materials. As an exhaustive exploration of the vast chemical space is still infeasible, we…

Machine Learning · Statistics 2020-01-10 Niklas W. A. Gebauer , Michael Gastegger , Kristof T. Schütt

Dose-Volume Histogram (DVH) prediction is fundamental in radiation therapy that facilitate treatment planning, dose evaluation, plan comparison and etc. It helps to increase the ability to deliver precise and effective radiation treatments…

Machine Learning · Computer Science 2024-02-05 Zehao Dong , Yixin Chen , Tianyu Zhao

In countries that enabled patients to choose their own providers, a common problem is that the patients did not make rational decisions, and hence, fail to use healthcare resources efficiently. This might cause problems such as overwhelming…

Computers and Society · Computer Science 2020-06-25 Lichin Chen , Yu Tsao , Ji-Tian Sheu

Generative models, such as large language models and text-to-image diffusion models, are increasingly used to create visual designs like user interfaces (UIs) and presentation slides. Finetuning and benchmarking these generative models have…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Yi-Hao Peng , Jeffrey P. Bigham , Jason Wu

Artificial intelligence (AI) is poised to transform healthcare by enabling personalized and efficient care through data-driven insights. Although radiology is at the forefront of AI adoption, in practice, the potential of AI models is often…

Computer Vision and Pattern Recognition · Computer Science 2025-02-17 Benjamin D. Killeen , Bohua Wan , Aditya V. Kulkarni , Nathan Drenkow , Michael Oberst , Paul H. Yi , Mathias Unberath

Generative modelling and synthetic data can be a surrogate for real medical imaging datasets, whose scarcity and difficulty to share can be a nuisance when delivering accurate deep learning models for healthcare applications. In recent…

Image and Video Processing · Electrical Eng. & Systems 2024-02-27 Virginia Fernandez , Walter Hugo Lopez Pinaya , Pedro Borges , Mark S. Graham , Tom Vercauteren , M. Jorge Cardoso

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

Medical Physics · Physics 2018-12-03 Dan Nguyen , Troy Long , Xun Jia , Weiguo Lu , Xuejun Gu , Zohaib Iqbal , Steve Jiang

This work aims to study the generalizability of a pre-developed deep learning (DL) dose prediction model for volumetric modulated arc therapy (VMAT) for prostate cancer and to adapt the model to three different internal treatment planning…

Stereotactic radiosurgery (SRS) demands precise dose shaping around critical structures, yet black-box AI systems have limited clinical adoption due to opacity concerns. We tested whether chain-of-thought reasoning improves agentic planning…

Generative Artificial Intelligence (GenAI) enables digital representatives to make decisions on behalf of team members in collaborative tasks, but faces challenges in accurately representing preferences. While supplying GenAI with detailed…

Computer Science and Game Theory · Computer Science 2025-12-16 Kexin Chen , Jianwei Huang , Yuan Luo

RLHF techniques like DPO can significantly improve the generation quality of text-to-image diffusion models. However, these methods optimize for a single reward that aligns model generation with population-level preferences, neglecting the…

Machine Learning · Computer Science 2025-01-14 Meihua Dang , Anikait Singh , Linqi Zhou , Stefano Ermon , Jiaming Song