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Epilepsy, affecting approximately 50 million people globally, is characterized by abnormal brain activity and remains challenging to treat. The diagnosis of epilepsy relies heavily on electroencephalogram (EEG) data, where specialists…

Generating clinical reports that summarize abnormal patterns, diagnostic findings, and clinical interpretations from long-term EEG recordings remains labor-intensive. We present CELM, the first clinical EEG-to-Language foundation model…

Machine Learning · Computer Science 2026-05-15 Jathurshan Pradeepkumar , Zheng Chen , Jimeng Sun

Electroencephalography (EEG) interpretation using multimodal large language models (MLLMs) offers a novel approach for analyzing brain signals. However, the complex nature of brain activity introduces critical challenges: EEG signals…

Signal Processing · Electrical Eng. & Systems 2025-10-02 Ziyi Zeng , Zhenyang Cai , Yixi Cai , Xidong Wang , Junying Chen , Rongsheng Wang , Yipeng Liu , Siqi Cai , Benyou Wang , Zhiguo Zhang , Haizhou Li

Brain computer interface (BCI) research, as well as increasing portions of the field of neuroscience, have found success deploying large-scale artificial intelligence (AI) pre-training methods in conjunction with vast public repositories of…

Neurons and Cognition · Quantitative Biology 2025-06-03 Mattson Ogg , Rahul Hingorani , Diego Luna , Griffin W. Milsap , William G. Coon , Clara A. Scholl

Cybersickness poses a serious challenge for users of virtual reality (VR) technology. Consequently, there has been significant effort to track its occurrence during VR use with passive measures like brain activity recorded through…

Human-Computer Interaction · Computer Science 2026-03-30 Jacqueline Yau , Katherine J. Mimnaugh , Evan G. Center , Timo Ojala , Steven M. LaValle , Wenzhen Yuan , Nancy Amato , Minje Kim , Kara D. Federmeier

This position paper argues that current benchmarking practice in 12-lead ECG representation learning must be fixed to ensure progress is reliable and aligned with clinically meaningful objectives. The field has largely converged on three…

Machine Learning · Computer Science 2026-02-20 Zachary Berger , Daniel Prakah-Asante , John Guttag , Collin M. Stultz

Despite the impressive advancements achieved using deep-learning for functional brain activity analysis, the heterogeneity of functional patterns and scarcity of imaging data still pose challenges in tasks such as prediction of future onset…

Image and Video Processing · Electrical Eng. & Systems 2023-12-25 Wenhui Cui , Haleh Akrami , Ganning Zhao , Anand A. Joshi , Richard M. Leahy

Measuring brain activity with electroencephalography (EEG) is mature enough to assess mental states. Combined with existing methods, such tool can be used to strengthen the understanding of user experience. We contribute a set of methods to…

Human-Computer Interaction · Computer Science 2016-01-13 Jérémy Frey , Maxime Daniel , Julien Castet , Martin Hachet , Fabien Lotte

EEG foundation models achieve state-of-the-art clinical performance, yet the internal computations driving their predictions remain opaque: a barrier to clinical trust. We apply TopK Sparse Autoencoders (SAEs) across three architecturally…

Electroencephalogram (EEG) is an important diagnostic test that physicians use to record brain activity and detect seizures by monitoring the signals. There have been several attempts to detect seizures and abnormalities in EEG signals with…

Machine Learning · Computer Science 2022-03-22 Kwanhyung Lee , Hyewon Jeong , Seyun Kim , Donghwa Yang , Hoon-Chul Kang , Edward Choi

Electroencephalography (EEG) is an objective tool for emotion recognition and shows promising performance. However, the label scarcity problem is a main challenge in this field, which limits the wide application of EEG-based emotion…

Signal Processing · Electrical Eng. & Systems 2024-09-02 Rushuang Zhou , Weishan Ye , Zhiguo Zhang , Yanyang Luo , Li Zhang , Linling Li , Gan Huang , Yining Dong , Yuan-Ting Zhang , Zhen Liang

Electroencephalography (EEG) is a method of recording brain activity that shows significant promise in applications ranging from disease classification to emotion detection and brain-computer interfaces. Recent advances in deep learning…

Machine Learning · Computer Science 2026-01-15 Amarpal Sahota , Navid Mohammadi Foumani , Raul Santos-Rodriguez , Zahraa S. Abdallah

This paper addresses both the various EEG applications and the current EEG market ecosystem propelled by machine learning. Increasingly available open medical and health datasets using EEG encourage data-driven research with a promise of…

Machine Learning · Computer Science 2022-08-11 Weiqing Gu , Bohan Yang , Ryan Chang

The early detection of Parkinsons disease remains a critical challenge in clinical neuroscience, with electroencephalography offering a noninvasive and scalable pathway toward population level screening. While machine learning has shown…

Signal Processing · Electrical Eng. & Systems 2026-03-17 Nicholas R. Rasmussen , Rodrigue Rizk , Longwei Wang , Arun Singh , KC Santosh

Large-scale models pre-trained on Electroencephalography (EEG) have shown promise in clinical applications such as neurological disorder detection. However, the practical deployment of EEG-based large-scale models faces critical challenges…

Machine Learning · Computer Science 2025-08-12 Guanghao Jin , Yuan Liang , Yihan Ma , Jingpei Wu , Guoyang Liu

Recordings of electrical brain activity carry information about a person's cognitive health. For recording EEG signals, a very common setting is for a subject to be at rest with its eyes closed. Analysis of these recordings often involve a…

Neurons and Cognition · Quantitative Biology 2018-12-18 Sebastian Mathias Keller , Maxim Samarin , Antonia Meyer , Vitalii Kosak , Ute Gschwandtner , Peter Fuhr , Volker Roth

This paper presents a novel graph convolutional neural network (GCNN)-based approach for improving the diagnosis of neurological diseases using scalp-electroencephalograms (EEGs). Although EEG is one of the main tests used for…

Signal Processing · Electrical Eng. & Systems 2020-11-25 Neeraj Wagh , Yogatheesan Varatharajah

EEG-based analysis of pain perception, enhanced by machine learning, reveals how the brain encodes pain by identifying neural patterns evoked by noxious stimulation. However, a major challenge that remains is the generalization of machine…

Signal Processing · Electrical Eng. & Systems 2025-08-19 Mathis Rezzouk , Fabrice Gagnon , Alyson Champagne , Mathieu Roy , Philippe Albouy , Michel-Pierre Coll , Cem Subakan

Physiological signals serve as indispensable clues for understanding various physiological states of human bodies. Most existing works have focused on a single type of physiological signals for a range of application scenarios. However, as…

Signal Processing · Electrical Eng. & Systems 2024-09-04 Daoze Zhang , Zhizhang Yuan , Junru Chen , Kerui Chen , Yang Yang

Electroencephalography (EEG) is a vital tool to measure and record brain activity in neuroscience and clinical applications, yet its potential is constrained by signal heterogeneity, low signal-to-noise ratios, and limited labeled datasets.…

Machine Learning · Computer Science 2024-09-20 Enze Shi , Kui Zhao , Qilong Yuan , Jiaqi Wang , Huawen Hu , Sigang Yu , Shu Zhang
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