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Efforts to ensure the safety of large language models (LLMs) include safety fine-tuning, evaluation, and red teaming. However, despite the widespread use of the Retrieval-Augmented Generation (RAG) framework, AI safety work focuses on…

Computation and Language · Computer Science 2025-04-28 Bang An , Shiyue Zhang , Mark Dredze

Advances in AI, particularly LLMs, have dramatically shortened drug discovery cycles by up to 40% and improved molecular target identification. However, these innovations also raise dual-use concerns by enabling the design of toxic…

Quantitative Methods · Quantitative Biology 2025-05-26 Gertrude Hattoh , Jeremiah Ayensu , Nyarko Prince Ofori , Solomon Eshun , Darlington Akogo

Large language models (LLMs) have demonstrated significant utility in real-world applications, exhibiting impressive capabilities in natural language processing and understanding. Benchmark evaluations are crucial for assessing the…

Computation and Language · Computer Science 2026-05-12 Wenbo Zhang , Hengrui Cai , Wenyu Chen

The proliferation of Large Language Models (LLMs) in real-world applications poses unprecedented risks of generating harmful, biased, or misleading information to vulnerable populations including LGBTQ+ individuals, single parents, and…

Computer Vision and Pattern Recognition · Computer Science 2025-09-12 Tung Vu , Lam Nguyen , Quynh Dao

Machine learning (ML) and artificial intelligence (AI) techniques have now become commonplace in software products and services. When threat modelling a system, it is therefore important that we consider threats unique to ML and AI…

Cryptography and Security · Computer Science 2024-01-17 Vimal Kumar , Juliette Mayo , Khadija Bahiss

Large Language Model (LLM) - based Automated Program Repair (APR) systems are increasingly integrated into modern software development workflows, offering automated patches in response to natural language bug reports. However, this reliance…

Software Engineering · Computer Science 2026-05-26 Piotr Przymus , Andreas Happe , Jürgen Cito

Recent advances in large language models (LLMs) have led to the development of powerful AI chatbots capable of engaging in natural and human-like conversations. However, these chatbots can be potentially harmful, exhibiting manipulative,…

Artificial Intelligence · Computer Science 2023-04-04 Baihan Lin , Djallel Bouneffouf , Guillermo Cecchi , Kush R. Varshney

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

As a result of rapidly accelerating AI capabilities, over the past year, national governments and multinational bodies have announced efforts to address safety, security and ethics issues related to AI models. One high priority among these…

Computers and Society · Computer Science 2026-05-19 Jaspreet Pannu , Doni Bloomfield , Alex Zhu , Robert MacKnight , Gabe Gomes , Anita Cicero , Thomas V. Inglesby

Navigating the vast and rapidly growing body of scientific literature is a formidable challenge for aspiring researchers. Current approaches to supporting research idea generation often rely on generic large language models (LLMs). While…

Artificial Intelligence · Computer Science 2025-06-17 Franklin Lee , Tengfei Ma

Frontier artificial intelligence (AI) systems could pose increasing risks to public safety and security. But what level of risk is acceptable? One increasingly popular approach is to define capability thresholds, which describe AI…

Computers and Society · Computer Science 2024-06-24 Leonie Koessler , Jonas Schuett , Markus Anderljung

In this study, we explored the progression trajectories of artificial intelligence (AI) systems through the lens of complexity theory. We challenged the conventional linear and exponential projections of AI advancement toward Artificial…

Artificial Intelligence · Computer Science 2024-07-08 Teo Susnjak , Timothy R. McIntosh , Andre L. C. Barczak , Napoleon H. Reyes , Tong Liu , Paul Watters , Malka N. Halgamuge

Evaluation insights are limited by the availability of high-quality benchmarks. As models evolve, there is a need to create benchmarks that can measure progress on new and complex generative capabilities. However, manually creating new…

Machine Learning · Computer Science 2025-10-08 Natasha Butt , Varun Chandrasekaran , Neel Joshi , Besmira Nushi , Vidhisha Balachandran

Amidst escalating concerns about the detriments inflicted by AI systems, risk management assumes paramount importance, notably for high-risk applications as demanded by the European Union AI Act. Guidelines provided by ISO and NIST aim to…

Computers and Society · Computer Science 2024-06-19 sundaraparipurnan Narayanan , Sandeep Vishwakarma

Although LLM-based agents, powered by Large Language Models (LLMs), can use external tools and memory mechanisms to solve complex real-world tasks, they may also introduce critical security vulnerabilities. However, the existing literature…

Cryptography and Security · Computer Science 2025-06-02 Hanrong Zhang , Jingyuan Huang , Kai Mei , Yifei Yao , Zhenting Wang , Chenlu Zhan , Hongwei Wang , Yongfeng Zhang

Large language models (LLMs) trained on internet-scale corpora can exhibit systematic biases that increase the probability of unwanted behavior. In this study, we examined potential biases towards synthetic vs. biological technological…

Computation and Language · Computer Science 2026-03-11 Trent R Northen , Mingxun Wang

Rapid advancements of large language models (LLMs) have enabled the processing, understanding, and generation of human-like text, with increasing integration into systems that touch our social sphere. Despite this success, these models can…

Computation and Language · Computer Science 2024-07-16 Isabel O. Gallegos , Ryan A. Rossi , Joe Barrow , Md Mehrab Tanjim , Sungchul Kim , Franck Dernoncourt , Tong Yu , Ruiyi Zhang , Nesreen K. Ahmed

Over the past year, artificial intelligence (AI) companies have been increasingly adopting AI safety frameworks. These frameworks outline how companies intend to keep the potential risks associated with developing and deploying frontier AI…

Computers and Society · Computer Science 2024-09-16 Jide Alaga , Jonas Schuett , Markus Anderljung

In recent years, with the rapid development of the depth and breadth of large language models' capabilities, various corresponding evaluation benchmarks have been emerging in increasing numbers. As a quantitative assessment tool for model…

Computation and Language · Computer Science 2025-08-22 Shiwen Ni , Guhong Chen , Shuaimin Li , Xuanang Chen , Siyi Li , Bingli Wang , Qiyao Wang , Xingjian Wang , Yifan Zhang , Liyang Fan , Chengming Li , Ruifeng Xu , Le Sun , Min Yang

The rapid advancement of Large Language Models (LLMs) in biological research has significantly lowered the barrier to accessing complex bioinformatics knowledge, ex perimental design strategies, and analytical workflows. While these…

Cryptography and Security · Computer Science 2026-03-25 Protiva Das , Sovon Chakraborty , Sidhant Narula , Lucas Potter , Xavier-Lewis Palmer , Pratip Rana , Daniel Takabi , Mohammad Ghasemigol
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