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Understanding the common topological characteristics of the human brain network across a population is central to understanding brain functions. The abstraction of human connectome as a graph has been pivotal in gaining insights on the…

Quantitative Methods · Quantitative Biology 2023-04-26 Soumya Das , D. Vijay Anand , Moo K. Chung

Real-world networks often benefit from capturing both local and global interactions. Inspired by multi-modal analysis in brain imaging, where structural and functional connectivity offer complementary views of network organization, we…

Neural and Evolutionary Computing · Computer Science 2025-08-11 Yang Li , Luopeiwen Yi , Tananun Songdechakraiwut

We present a novel physics-informed deep learning framework for solving steady-state incompressible flow on multiple sets of irregular geometries by incorporating two main elements: using a point-cloud based neural network to capture…

Fluid Dynamics · Physics 2022-10-28 Ali Kashefi , Tapan Mukerji

To preserve previously learned representations, continual learning systems must strike a balance between plasticity, the ability to acquire new knowledge, and stability. This stability-plasticity dilemma affects how representations can be…

Machine Learning · Computer Science 2026-05-01 Kathrin Korte , Joachim Winter Pedersen , Eleni Nisioti , Sebastian Risi

While modern deep networks have demonstrated remarkable versatility, their training dynamics remain poorly understood--often driven more by empirical tweaks than architectural insight. This paper investigates how internal structural choices…

Machine Learning · Computer Science 2025-08-26 Saleh Nikooroo , Thomas Engel

Spatial networks are networks whose graph topology is constrained by their embedded spatial space. Understanding the coupled spatial-graph properties is crucial for extracting powerful representations from spatial networks. Therefore,…

Machine Learning · Computer Science 2024-01-11 Zheng Zhang , Sirui Li , Jingcheng Zhou , Junxiang Wang , Abhinav Angirekula , Allen Zhang , Liang Zhao

In this work, we explore links between natural homology and persistent homology for the classification of directed spaces. The former is an algebraic invariant of directed spaces, a semantic model of concurrent programs. The latter was…

Algebraic Topology · Mathematics 2024-08-07 Cameron Calk , Eric Goubault , Philippe Malbos

A central challenge in topological data analysis is the interpretation of barcodes. The classical algebraic-topological approach to interpreting homology classes is to build maps to spaces whose homology carries semantics we understand and…

Algebraic Topology · Mathematics 2023-08-11 Iris H. R. Yoon , Robert Ghrist , Chad Giusti

Point cloud learning often rests on the premise that observed samples are noisy traces of an underlying geometric object, such as a manifold embedded in a high-dimensional feature space. Yet much of this geometry is not captured directly by…

Machine Learning · Computer Science 2026-05-18 Bruno Trentini , Jacob Hume , Vincenzo Antonio Isoldi , Philipp Misof , Ekaterina S. Ivshina , Kelly Maggs

Accurate delineation of fine-scale structures is a very important yet challenging problem. Existing methods use topological information as an additional training loss, but are ultimately making pixel-wise predictions. In this paper, we…

Image and Video Processing · Electrical Eng. & Systems 2022-10-04 Xiaoling Hu , Dimitris Samaras , Chao Chen

Deep neural networks come in many sizes and architectures. The choice of architecture, in conjunction with the dataset and learning algorithm, is commonly understood to affect the learned neural representations. Yet, recent results have…

Machine Learning · Computer Science 2024-07-08 Loek van Rossem , Andrew M. Saxe

Algorithms for persistent homology and zigzag persistent homology are well-studied for persistence modules where homomorphisms are induced by inclusion maps. In this paper, we propose a practical algorithm for computing persistence under…

Computational Geometry · Computer Science 2014-03-26 Tamal K. Dey , Fengtao Fan , Yusu Wang

Although deep learning approaches have had tremendous success in image, video and audio processing, computer vision, and speech recognition, their applications to three-dimensional (3D) biomolecular structural data sets have been hindered…

Quantitative Methods · Quantitative Biology 2017-11-01 Zixuan Cang , Guo-Wei Wei

We start with a simple introduction to topological data analysis where the most popular tool is called a persistent diagram. Briefly, a persistent diagram is a multiset of points in the plane describing the persistence of topological…

Statistics Theory · Mathematics 2017-06-28 Christophe Biscio , Jesper Møller

Our theoretical understanding of deep learning has not kept pace with its empirical success. While network architecture is known to be critical, we do not yet understand its effect on learned representations and network behavior, or how…

Machine Learning · Computer Science 2022-07-22 Andrew M. Saxe , Shagun Sodhani , Sam Lewallen

We discuss and review recent developments in the area of applied algebraic topology, such as persistent homology and barcodes. In particular, we discuss how these are related to understanding more about manifold learning from random point…

Probability · Mathematics 2015-03-13 Robert J. Adler , Omer Bobrowski , Matthew S. Borman , Eliran Subag , Shmuel Weinberger

The human brain is a complex inter-wired system that emerges spontaneous functional fluctuations. In spite of tremendous success in the experimental neuroscience field, a system-level understanding of how brain anatomy supports various…

Neurons and Cognition · Quantitative Biology 2024-05-28 Tingting Dan , Ziquan Wei , Won Hwa Kim , Guorong Wu

We present STITCH, a novel approach for neural implicit surface reconstruction of a sparse and irregularly spaced point cloud while enforcing topological constraints (such as having a single connected component). We develop a new…

Computer Vision and Pattern Recognition · Computer Science 2025-01-10 Anushrut Jignasu , Ethan Herron , Zhanhong Jiang , Soumik Sarkar , Chinmay Hegde , Baskar Ganapathysubramanian , Aditya Balu , Adarsh Krishnamurthy

Aqueous solubility and partition coefficient are important physical properties of small molecules. Accurate theoretical prediction of aqueous solubility and partition coefficient plays an important role in drug design and discovery. The…

Quantitative Methods · Quantitative Biology 2018-01-08 Kedi Wu , Zhixiong Zhao , Renxiao Wang , Guo-Wei Wei

Graph Neural Networks (GNNs) have become the standard for graph representation learning but remain vulnerable to structural perturbations. We propose a novel framework that integrates persistent homology features with stability…

Machine Learning · Computer Science 2025-12-17 Jelena Losic