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In the evolving landscape of clinical informatics, the integration and utilization of software tools developed through governmental funding represent a pivotal advancement in research and application. However, the dispersion of these tools…
PubMed is a freely accessible system for searching the biomedical literature, with approximately 2.5 million users worldwide on an average workday. We have recently developed PubMed Labs (www.pubmed.gov/labs), an experimental platform for…
Clinical trials are a critical component of evaluating the effectiveness of new medical interventions and driving advancements in medical research. Therefore, timely enrollment of patients is crucial to prevent delays or premature…
Clinical trial records are variable resources or the analysis of patients and diseases. Information extraction from free text such as eligibility criteria and summary of results and conclusions in clinical trials would better support…
This article presents our steps to integrate complex and partly unstructured medical data into a clinical research database with subsequent decision support. Our main application is an integrated faceted search tool, accompanied by the…
As Large Language Models increasingly power role-playing applications, simulating patients has become a valuable tool for training counselors and scaling therapeutic assessment. However, prior work is fragmented: existing approaches rely on…
We introduce Trialstreamer, a living database of clinical trial reports. Here we mainly describe the evidence extraction component; this extracts from biomedical abstracts key pieces of information that clinicians need when appraising the…
Combining clinical and omics data can improve both daily clinical routines and research to gain more insights into complex medical procedures. We present the results of our first phase in a multi-year collaboration with analysts and…
The governance of data used for biomedical research and clinical trials is an important requirement for generating accurate results. To improve the visibility of data quality and analysis, we developed TrialChain, a blockchain-based…
We present Clinica (www.clinica.run), an open-source software platform designed to make clinical neuroscience studies easier and more reproducible. Clinica aims for researchers to i) spend less time on data management and processing, ii)…
Clinical trials are crucial for assessing new treatments; however, recruitment challenges - such as limited awareness, complex eligibility criteria, and referral barriers - hinder their success. With the growth of online platforms, patients…
Topic pages aggregate useful information about an entity or concept into a single succinct and accessible article. Automated creation of topic pages would enable their rapid curation as information resources, providing an alternative to…
Health care professionals rely on treatment search engines to efficiently find adequate clinical trials and early access programs for their patients. However, doctors lose trust in the system if its underlying processes are unclear and…
Using personal generated health data (PGHD) during medical consultations can be beneficial for both patients and clinicians. However, multiple acceptance barriers such as lack of PGHD reliability prevents a routine usage of this data. A…
Existing medical RAG systems mainly leverage knowledge from medical knowledge bases, neglecting the crucial role of experiential knowledge derived from similar patient cases -- a key component of human clinical reasoning. To bridge this…
Patient recruitment remains a major bottleneck in clinical trials, calling for scalable and automated solutions. We present TrialMatchAI, an AI-powered recommendation system that automates patient-to-trial matching by processing…
The Linked Clinical Trials (LinkedCT) project aims at publishing the first open semantic web data source for clinical trials data. The database exposed by LinkedCT is generated by (1) transforming existing data sources of clinical trials…
Clinical diagnosis requires answers that are accurate, verifiable, and explicitly grounded in official guidelines. While large language models excel at natural language processing, their tendency to hallucinate undermines their utility in…
A new clinical literature search engine, called CupQ, is presented. It aims to help clinicians stay updated with medical knowledge. Although PubMed is currently one of the most widely used digital libraries for biomedical information, it…
Laboratory research is a complex, collaborative process that involves several stages, including hypothesis formulation, experimental design, data generation and analysis, and manuscript writing. Although reproducibility and data sharing are…