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Motivation: Detection of structural variants (SV) from the alignment of sample DNA reads to the reference genome is an important problem in understanding human diseases. Long reads that can span repeat regions, along with an accurate…

Genomics · Quantitative Biology 2023-01-25 Dhaivat Joshi , Suhas Diggavi , Mark J. P. Chaisson , Sreeram Kannan

We propose a method for adaptive nonlinear sequential modeling of vector-time series data. Data is modeled as a nonlinear function of past values corrupted by noise, and the underlying non-linear function is assumed to be approximately…

Methodology · Statistics 2017-10-11 Qiuyi Han , Jie Ding , Edoardo Airoldi , Vahid Tarokh

Pre-trained language models have shown stellar performance in various downstream tasks. But, this usually comes at the cost of high latency and computation, hindering their usage in resource-limited settings. In this work, we propose a…

Computation and Language · Computer Science 2022-03-18 Ali Modarressi , Hosein Mohebbi , Mohammad Taher Pilehvar

There are more than 7,000 languages around the world, and current Large Language Models (LLMs) only support hundreds of languages. Dictionary-based prompting methods can enhance translation on them, but most methods use all the available…

Computation and Language · Computer Science 2026-05-20 Hongyuan Lu , Zixuan Li , Zefan Zhang , Wai Lam

Existing Multimodal Large Language Models (MLLMs) suffer from significant performance degradation on the long document understanding task as document length increases. This stems from two fundamental challenges: 1) a low Signal-to-Noise…

Artificial Intelligence · Computer Science 2026-05-12 Hao Yan , Yuliang Liu , Xingchen Liu , Yuyi Zhang , Minghui Liao , Jihao Wu , Wei Chen , Xiang Bai

We propose weakly supervised language localization networks (WSLLN) to detect events in long, untrimmed videos given language queries. To learn the correspondence between visual segments and texts, most previous methods require temporal…

Computer Vision and Pattern Recognition · Computer Science 2019-09-04 Mingfei Gao , Larry S. Davis , Richard Socher , Caiming Xiong

Large language models (LLMs) have achieved remarkable success across widespread tasks, yet their application in low-resource domains remains a significant challenge due to data scarcity and the high risk of overfitting. While in-domain data…

Computation and Language · Computer Science 2025-11-11 Pingjie Wang , Hongcheng Liu , Yusheng Liao , Ziqing Fan , Yaxin Du , Shuo Tang , Yanfeng Wang , Yu Wang

Despite growing interest in using large language models (LLMs) to automate annotation, their effectiveness in complex, nuanced, and multi-dimensional labelling tasks remains relatively underexplored. This study focuses on annotation for the…

Information Retrieval · Computer Science 2025-07-02 Leila Tavakoli , Hamed Zamani

Instruction tuning benefits from large and diverse datasets; however, creating such datasets involves a high cost of human labeling. While synthetic datasets generated by large language models (LLMs) have partly solved this issue, they…

Computation and Language · Computer Science 2024-08-28 Ritik Sachin Parkar , Jaehyung Kim , Jong Inn Park , Dongyeop Kang

We present crowdsourcing as an additional modality to aid radiologists in the diagnosis of lung cancer from clinical chest computed tomography (CT) scans. More specifically, a complete workflow is introduced which can help maximize the…

Computer Vision and Pattern Recognition · Computer Science 2018-09-19 Saeed Boorboor , Saad Nadeem , Ji Hwan Park , Kevin Baker , Arie Kaufman

Propaganda detection on social media remains challenging due to task complexity and limited high-quality labeled data. This paper introduces a novel framework that combines human expertise with Large Language Model (LLM) assistance to…

Computation and Language · Computer Science 2025-07-25 Ariana Sahitaj , Premtim Sahitaj , Veronika Solopova , Jiaao Li , Sebastian Möller , Vera Schmitt

Knowing the effect of an intervention is critical for human decision-making, but current approaches for causal effect estimation rely on manual data collection and structuring, regardless of the causal assumptions. This increases both the…

Machine Learning · Computer Science 2024-10-29 Nikita Dhawan , Leonardo Cotta , Karen Ullrich , Rahul G. Krishnan , Chris J. Maddison

Motivation: The rapid growth of metagenomics sequencing data makes metagenomics increasingly dependent on computational and statistical methods for fast and efficient analysis. Consequently, novel analysis tools for big-data metagenomics…

Genomics · Quantitative Biology 2022-10-19 Kaoutar Daoud Hiri , Matjaž Hren , Tomaž Curk

Reliability in cell type annotation is challenging in single-cell RNA-sequencing data analysis because both expert-driven and automated methods can be biased or constrained by their training data, especially for novel or rare cell types.…

Quantitative Methods · Quantitative Biology 2024-09-25 Wenjin Ye , Yuanchen Ma , Junkai Xiang , Hongjie Liang , Tao Wang , Qiuling Xiang , Andy Peng Xiang , Wu Song , Weiqiang Li , Weijun Huang

Relying on crowdsourced workers, data crowdsourcing platforms are able to efficiently provide vast amounts of labeled data. Due to the variability in the annotation quality of crowd workers, modern techniques resort to redundant annotations…

Human-Computer Interaction · Computer Science 2023-11-28 Haoyu Liu , Fei Wang , Minmin Lin , Runze Wu , Renyu Zhu , Shiwei Zhao , Kai Wang , Tangjie Lv , Changjie Fan

Objective. Annotation is expensive but essential for clinical note review and clinical natural language processing (cNLP). However, the extent to which computer-generated pre-annotation is beneficial to human annotation is still an open…

Alignment with human preference prevents large language models (LLMs) from generating misleading or toxic content while requiring high-cost human feedback. Assuming resources of human annotation are limited, there are two different ways of…

Computation and Language · Computer Science 2024-04-02 Feifan Song , Bowen Yu , Hao Lang , Haiyang Yu , Fei Huang , Houfeng Wang , Yongbin Li

Standard myopic active learning assumes that human annotations are always obtainable whenever new samples are selected. This, however, is unrealistic in many real-world applications where human experts are not readily available at all…

Machine Learning · Statistics 2018-05-18 Yazhou Yang , Marco Loog

Recent results in coupled or temporal graphical models offer schemes for estimating the relationship structure between features when the data come from related (but distinct) longitudinal sources. A novel application of these ideas is for…

Machine Learning · Statistics 2017-11-22 Ronak Mehta , Hyunwoo J. Kim , Shulei Wang , Sterling C. Johnson , Ming Yuan , Vikas Singh

Pre-trained contextualized language models (PrLMs) have led to strong performance gains in downstream natural language understanding tasks. However, PrLMs can still be easily fooled by adversarial word substitution, which is one of the most…

Computation and Language · Computer Science 2021-06-01 Rongzhou Bao , Jiayi Wang , Hai Zhao