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Recently, growth in our understanding of the computations performed in both biological and artificial neural networks has largely been driven by either low-level mechanistic studies or global normative approaches. However, concrete…

Neurons and Cognition · Quantitative Biology 2023-12-25 Michael Kuoch , Chi-Ning Chou , Nikhil Parthasarathy , Joel Dapello , James J. DiCarlo , Haim Sompolinsky , SueYeon Chung

Despite significant progress in the development of neural-symbolic frameworks, the question of how to integrate a neural and a symbolic system in a \emph{compositional} manner remains open. Our work seeks to fill this gap by treating these…

Artificial Intelligence · Computer Science 2020-10-23 Efthymia Tsamoura , Loizos Michael

Interpretation and diagnosis of machine learning models have gained renewed interest in recent years with breakthroughs in new approaches. We present Manifold, a framework that utilizes visual analysis techniques to support interpretation,…

Machine Learning · Computer Science 2019-01-18 Jiawei Zhang , Yang Wang , Piero Molino , Lezhi Li , David S. Ebert

Neurons in the brain are often finely tuned for specific task variables. Moreover, such disentangled representations are highly sought after in machine learning. Here we mathematically prove that simple biological constraints on neurons,…

Neurons and Cognition · Quantitative Biology 2023-04-04 James C. R. Whittington , Will Dorrell , Surya Ganguli , Timothy E. J. Behrens

Mounting experimental evidence suggests that brain-state-specific neural mechanisms, supported by connectomic architectures, play a crucial role in integrating past and contextual knowledge with the current, incoming flow of evidence (e.g.,…

A major goal of neuroscience is to understand brain computations during visual processing in naturalistic settings. A dominant approach is to use image-computable deep neural networks trained with different task objectives as a basis for…

Neurons and Cognition · Quantitative Biology 2026-02-06 Hossein Adeli , Sun Minni , Nikolaus Kriegeskorte

We propose NEURONA, a neuro-symbolic framework for fMRI decoding and concept grounding in neural activity. Leveraging image- and video-based fMRI question-answering datasets, NEURONA learns to decode interacting concepts from visual stimuli…

Neurons and Cognition · Quantitative Biology 2026-03-05 Yanchen Wang , Joy Hsu , Ehsan Adeli , Jiajun Wu

Computational models have become an essential part of exploratory protocols in cell biology, as a complement to in vivo or in vitro experiments. These virtual models have the twofold advantage of enabling access to new types of data and…

Medical Physics · Physics 2021-12-20 Maxime Vassaux , Laurent Pieuchot , Karine Anselme , Maxence Bigerelle , Jean-Louis Milan

Computation in the brain involves multiple types of neurons, yet the organizing principles for how these neurons work together remain unclear. Information theory has offered explanations for how different types of neurons can optimize the…

Neurons and Cognition · Quantitative Biology 2015-06-22 David B. Kastner , Stephen A. Baccus , Tatyana O. Sharpee

Recently, deep feedforward neural networks have achieved considerable success in modeling biological sensory processing, in terms of reproducing the input-output map of sensory neurons. However, such models raise profound questions about…

Neurons and Cognition · Quantitative Biology 2019-12-16 Hidenori Tanaka , Aran Nayebi , Niru Maheswaranathan , Lane McIntosh , Stephen A. Baccus , Surya Ganguli

This paper proposes a neuronal circuitry layout and synaptic plasticity principles that allow the (pyramidal) neuron to act as a "combinatorial switch". Namely, the neuron learns to be more prone to generate spikes given those combinations…

Biological Physics · Physics 2017-05-09 Marat M. Rvachev

The spiking activity of principal cells in mammalian hippocampus encodes an internalized neuronal representation of the ambient space---a cognitive map. Once learned, such a map enables the animal to navigate a given environment for a long…

Neurons and Cognition · Quantitative Biology 2017-10-10 Andrey Babichev , Dmitriy Morozov , Yuri Dabaghian

The ongoing exponential rise in recording capacity calls for new approaches for analysing and interpreting neural data. Effective dimensionality has emerged as an important property of neural activity across populations of neurons, yet…

Neurons and Cognition · Quantitative Biology 2021-08-30 Mehrdad Jazayeri , Srdjan Ostojic

Encoding models enable measurement of how our brains represent sensory inputs using electro-and magneto-encephalography (MEEG). Evaluating how closely encoding models reflect the underlying brain functions is a crucial premise for model…

Neurons and Cognition · Quantitative Biology 2026-04-17 Giovanni M. Di Liberto

Conventional modeling approaches have found limitations in matching the increasingly detailed neural network structures and dynamics recorded in experiments to the diverse brain functionalities. On another approach, studies have…

Neurons and Cognition · Quantitative Biology 2017-09-05 Chaofei Hong

Many neural systems display cascading behavior characterized by uninterrupted sequences of neuronal firing. This gap precludes an understanding of how variations in network structure manifest in neural dynamics and either support or impinge…

Neurons and Cognition · Quantitative Biology 2019-11-12 Harang Ju , Jason Z. Kim , Danielle S. Bassett

Conceptual and mathematical models of neurons have lagged behind empirical understanding for decades. Here we extend previous work in modeling biological systems with fully scale-independent quantum information-theoretic tools to develop a…

Neurons and Cognition · Quantitative Biology 2022-07-21 Chris Fields , James F. Glazebrook , Michael Levin

We present a foundation model for brain MRI that can work with different combinations of imaging sequences. The model uses one encoder with learnable modality embeddings, conditional layer normalization, and a masked autoencoding objective…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Minh Sao Khue Luu , Bair N. Tuchinov

Computational modeling and simulation have become essential tools in the quest to better understand the brain's makeup and to decipher the causal interrelations of its components. The breadth of biochemical and biophysical processes and…

Neurons and Cognition · Quantitative Biology 2019-06-10 Francesco Cremonesi , Felix Schürmann

Our knowledge of the sensory world is encoded by neurons in sequences of discrete, identical pulses termed action potentials or spikes. There is persistent controversy about the extent to which the precise timing of these spikes is relevant…

Neurons and Cognition · Quantitative Biology 2007-05-23 Ilya Nemenman , Geoffrey D. Lewen , William Bialek , Rob R. de Ruyter van Steveninck