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The oxidation state (OS) is an essential chemical concept that embodies chemical intuition but cannot be computed with well-defined physical laws. We establish a data-driven paradigm, with its implementation as Tsinghua Oxidation States in…

Chemical Physics · Physics 2025-07-30 Yue Yin , Hai Xiao

Root-mean-square deviation (RMSD) is widely used to assess structural similarity in systems ranging from flexible ligand conformers to complex molecular cluster configurations. Despite its wide utility, RMSD calculation is often challenged…

Biomolecules · Quantitative Biology 2025-09-03 Xiaoqi Wei , Xuhang Dai , Yaqi Wu , Yanxiang Zhao , Yingkai Zhang , Zixuan Cang

Efficiently and accurately determining the symmetry is a crucial step in the structural analysis of crystalline materials. Existing methods usually mindlessly apply deep learning models while ignoring the underlying chemical rules. More…

Machine Learning · Computer Science 2025-11-11 Liheng Yu , Zhe Zhao , Xucong Wang , Di Wu , Pengkun Wang

Accurate modelling of electrostatic interactions and charge transfer is fundamental to computational chemistry, yet most machine learning interatomic potentials (MLIPs) rely on local atomic descriptors that cannot capture long-range…

The generation of plausible crystal structures is often the first step in predicting the structure and properties of a material from its chemical composition. Quickly generating and predicting inorganic crystal structures is important for…

Materials Science · Physics 2024-02-13 Luis M. Antunes , Keith T. Butler , Ricardo Grau-Crespo

In this study, we present a novel approach along with the needed computational strategies for efficient and scalable feature engineering of the crystal structure in compounds of different chemical compositions. This approach utilizes a…

Materials Science · Physics 2021-05-25 Prathik R. Kaundinya , Kamal Choudhary , Surya R. Kalidindi

Predicting the structure of multi-protein complexes is a grand challenge in biochemistry, with major implications for basic science and drug discovery. Computational structure prediction methods generally leverage pre-defined structural…

Biomolecules · Quantitative Biology 2021-01-26 Stephan Eismann , Raphael J. L. Townshend , Nathaniel Thomas , Milind Jagota , Bowen Jing , Ron O. Dror

Deep generative models have shown promise for modeling metal-organic frameworks (MOFs), but existing approaches (1) rely on coarse-grained representations that assume fixed bond lengths and angles, and (2) neglect the MOF-adsorbate…

Materials Science · Physics 2026-02-10 Nayoung Kim , Honghui Kim , Sihyun Yu , Minkyu Kim , Seongsu Kim , Sungsoo Ahn

Materials identification and structural understanding from powder X-ray diffraction (PXRD) data is a long-standing challenge in materials science, fundamental to discovering and characterizing novel materials. A prerequisite for full…

The accurate prediction of material properties is crucial in a wide range of scientific and engineering disciplines. Machine learning (ML) has advanced the state of the art in this field, enabling scientists to discover novel materials and…

Materials Science · Physics 2024-08-20 Qinyang Li , Nicholas Miklaucic , Jianjun Hu

Atomic orbitals underpin our understanding of electronic structure, providing intuitive descriptions of bonding, charge transfer, magnetism, and correlation effects. Despite their utility, an atomic basis that is adaptable, strictly…

Materials Science · Physics 2026-04-07 Emily Oliphant , Emmanouil Kioupakis , Wenhao Sun

The increased time- and length-scale of classical molecular dynamics simulations have led to raw data flows surpassing storage capacities, necessitating on-the-fly integration of structural analysis algorithms. As a result, algorithms must…

The ionic bonding across the lattice and ordered microscopic structures endow crystals with unique symmetry and determine their macroscopic properties. Unconventional crystals, in particular, exhibit non-traditional lattice structures or…

Materials Science · Physics 2024-11-04 Hongyi Wang , Ji Sun , Jinzhe Liang , Li Zhai , Zitian Tang , Zijian Li , Wei Zhai , Xusheng Wang , Weihao Gao , Sheng Gong

To determine crystal structures from an X-ray diffraction (XRD) pattern containing multiple unknown phases, a data-assimilated crystal growth (DACG) simulation method has been developed. The XRD penalty function selectively stabilizes the…

Materials Science · Physics 2024-05-17 Yuuki Kubo , Ryuhei Sato , Yuansheng Zhao , Takahiro Ishikawa , Shinji Tsuneyuki

Crystal structure forms the foundation for understanding the physical and chemical properties of materials. Generative models have emerged as a new paradigm in crystal structure prediction(CSP), however, accurately capturing key…

Materials Science · Physics 2025-02-14 Ziyi Chen , Yang Yuan , Siming Zheng , Jialong Guo , Sihan Liang , Yangang Wang , Zongguo Wang

The robust and automated determination of crystal symmetry is of utmost importance in material characterization and analysis. Recent studies have shown that deep learning (DL) methods can effectively reveal the correlations between X-ray or…

Computational Physics · Physics 2020-05-27 Leslie Ching Ow Tiong , Jeongrae Kim , Sang Soo Han , Donghun Kim

Determining crystal structures from experimental powder X-ray diffraction data remains challenging because peak overlap, preferred orientation, and impurity phases obscure atomic arrangements. We present RealPXRD-Solver, a generative model…

Colloidal self-assembly -- the spontaneous organization of colloids into ordered structures -- has been considered key to produce next-generation materials. However, the present-day staggering variety of colloidal building blocks and the…

Soft Condensed Matter · Physics 2021-06-29 Gabriele Maria Coli , Emanuele Boattini , Laura Filion , Marjolein Dijkstra

Organic crystalline materials are potential candidates for photocatalytic overall water splitting (OWS). Although organic crystals have been heavily investigated for application in organic electronics, such as organic light-emitting diodes…

Materials Science · Physics 2026-02-23 James D. Green , Daniel G. Medranda , Hong Wang , Andrew I. Cooper , Jenny Nelson , Kim E. Jelfs

Organic molecular crystals are ideally placed to become next-generation piezoelectric materials due to their diverse chemistries that can be used to engineer tailor-made solid-state assemblies. Using crystal engineering principles, and…

Materials Science · Physics 2024-12-11 Shubham Vishnoi , Geetu Kumari , Robert Guest , Pierre-André Cazade , Sarah Guerin