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Agentic AI systems powered by Large Language Models (LLMs) as their foundational reasoning engine, are transforming clinical workflows such as medical report generation and clinical summarization by autonomously analyzing sensitive…

Multiagent Systems · Computer Science 2025-05-08 Subash Neupane , Sudip Mittal , Shahram Rahimi

As AI agents powered by Large Language Models (LLMs) become increasingly versatile and capable of addressing a broad spectrum of tasks, ensuring their security has become a critical challenge. Among the most pressing threats are prompt…

Agentic AI systems -- Large Language Models (LLMs) augmented with planning, tool use, memory, and long-horizon interactions -- can execute complex tasks autonomously, but their multi-step trajectories introduce new failure modes that…

Artificial Intelligence · Computer Science 2026-05-26 Jinhu Qi , Muzhi Li , Jiahong Liu , Yuqin Shu , Dianzhi Yu , Shicheng Ma , Wenqian Cui , Yiyang Zhao , Yiyi Chen , Ruoxi Jiang , Irwin King , Zenglin Xu

Backdoor attacks pose a serious threat to deep learning models by allowing adversaries to implant hidden behaviors that remain dormant on clean inputs but are maliciously triggered at inference. Existing backdoor attack methods typically…

Cryptography and Security · Computer Science 2025-11-18 Lijie Hu , Junchi Liao , Weimin Lyu , Shaopeng Fu , Tianhao Huang , Shu Yang , Guimin Hu , Di Wang

Large Language Models (LLMs) have demonstrated remarkable capabilities in performing tasks across various domains without needing explicit retraining. This capability, known as In-Context Learning (ICL), while impressive, exposes LLMs to a…

Computation and Language · Computer Science 2024-10-16 Bibek Upadhayay , Vahid Behzadan , Amin Karbasi

Indirect prompt injection attacks (IPIAs), where large language models (LLMs) follow malicious instructions hidden in input data, pose a critical threat to LLM-powered agents. In this paper, we present IntentGuard, a general defense…

Cryptography and Security · Computer Science 2025-12-02 Mintong Kang , Chong Xiang , Sanjay Kariyappa , Chaowei Xiao , Bo Li , Edward Suh

Large language model (LLM) agents have demonstrated remarkable capabilities in complex reasoning and decision-making by leveraging external tools. However, this tool-centric paradigm introduces a previously underexplored attack surface,…

Artificial Intelligence · Computer Science 2026-01-08 Kanghua Mo , Li Hu , Yucheng Long , Zhihao Li

The emergence of Large Language Models (LLMs) has significantly advanced solutions across various domains, from political science to software development. However, these models are constrained by their training data, which is static and…

Artificial Intelligence · Computer Science 2025-09-16 Aadil Gani Ganie

As large language models transition from bounded generative engines to agents with expansive execution privileges, AI going out of control precipitates a fundamental crisis in artificial intelligence security. Existing defense architectures…

Artificial Intelligence · Computer Science 2026-05-29 Benlong Wu , Weiming Zhang , Kejiang Chen , Han Fang , Nenghai Yu

Large Language Models (LLMs) are increasingly deployed in agentic systems that interact with an untrusted environment. However, LLM agents are vulnerable to prompt injection attacks when handling untrusted data. In this paper we propose…

AI agents such as OpenClaw are increasingly deployed in local workflows with access to external tools. This creates indirect prompt-injection (IPI) risk: an agent may execute harmful instructions embedded in untrusted inputs such as email,…

Cryptography and Security · Computer Science 2026-05-26 Lei Zhao , Abhay Bhaskar , Edgar Dobriban

AI agents equipped with tool-calling capabilities are susceptible to Indirect Prompt Injection (IPI) attacks. In this attack scenario, malicious commands hidden within untrusted content trick the agent into performing unauthorized actions.…

Cryptography and Security · Computer Science 2026-02-10 Minbeom Kim , Mihir Parmar , Phillip Wallis , Lesly Miculicich , Kyomin Jung , Krishnamurthy Dj Dvijotham , Long T. Le , Tomas Pfister

Agentic AI systems - capable of goal interpretation, world modeling, planning, tool use, long-horizon operation, and autonomous coordination - introduce distinct control failures not addressed by existing safety frameworks. We identify six…

Computers and Society · Computer Science 2026-03-05 Subramanyam Sahoo

The increasing integration of AI agents into cyber-physical systems (CPS) introduces new security risks that extend beyond traditional cyber or physical threat models. Recent advances in generative AI enable deepfake and semantic…

Cryptography and Security · Computer Science 2026-01-29 Mohsen Hatami , Van Tuan Pham , Hozefa Lakadawala , Yu Chen

Recent AI systems combine large language models with tools, external knowledge via retrieval-augmented generation (RAG), and even autonomous multi-agent decision loops. This agentic AI paradigm greatly expands capabilities - but also vastly…

Cryptography and Security · Computer Science 2026-03-25 Ali Dehghantanha , Sajad Homayoun

Computer-use agents(CUAs)are moving frombounded benchmarks toward real software environments, wherethey operate browsers, desktops, mobile applications, flesystems,terminals, and tool backends. In such settings, reliability isno longer…

Computation and Language · Computer Science 2026-05-11 Zejian Chen , Zhanyuan Liu , Chaozhuo Li , Mengxiang Han , Songyang Liu , Litian Zhang , Feng Gao , Yiming Hei , Xi Zhang

Recent evidence suggests that frontier AI systems can exhibit agentic misalignment, generating and executing harmful actions derived from internally constructed goals, even without explicit user requests. Existing mitigation methods, such…

Artificial Intelligence · Computer Science 2026-04-28 Rong Xiang

Agentic AI systems powered by large language models (LLMs) and endowed with planning, tool use, memory, and autonomy, are emerging as powerful, flexible platforms for automation. Their ability to autonomously execute tasks across web,…

Artificial Intelligence · Computer Science 2026-04-07 Anshuman Chhabra , Shrestha Datta , Shahriar Kabir Nahin , Prasant Mohapatra

Cybersecurity is being fundamentally reshaped by foundation-model-based artificial intelligence. Large language models now enable autonomous planning, tool orchestration, and strategic adaptation at scale, challenging security architectures…

Cryptography and Security · Computer Science 2025-12-30 Tao Li , Quanyan Zhu

Defending computer networks from cyber attack requires timely responses to alerts and threat intelligence. Decisions about how to respond involve coordinating actions across multiple nodes based on imperfect indicators of compromise while…

Cryptography and Security · Computer Science 2021-11-05 John Mern , Kyle Hatch , Ryan Silva , Cameron Hickert , Tamim Sookoor , Mykel J. Kochenderfer