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Accelerated MRI protocols routinely involve a predefined sampling pattern that undersamples the k-space. Finding an optimal pattern can enhance the reconstruction quality, however this optimization is a challenging task. To address this…

Image and Video Processing · Electrical Eng. & Systems 2024-08-30 Cagan Alkan , Morteza Mardani , Congyu Liao , Zhitao Li , Shreyas S. Vasanawala , John M. Pauly

The identification of the interface of an inclusion in a diffusion process is considered. This task is viewed as a parameter identification problem in which the parameter space bears the structure of a shape manifold. A corresponding…

Optimization and Control · Mathematics 2021-04-12 Tommy Etling , Roland Herzog , Martin Siebenborn

In X-ray Computed Tomography (CT), projections from many angles are acquired and used for 3D reconstruction. To make CT suitable for in-line quality control, reducing the number of angles while maintaining reconstruction quality is…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Tianyuan Wang , Felix Lucka , Tristan van Leeuwen

The goal of this paper is to make Optimal Experimental Design (OED) computationally feasible for problems involving significant computational expense. We focus exclusively on the Mean Objective Cost of Uncertainty (MOCU), which is a…

Optimization and Control · Mathematics 2020-12-09 Anthony M. DeGennaro , Francis J. Alexander

Low-field magnetic resonance imaging (MRI) offers a cost-effective alternative for medical imaging in resource-limited settings. However, its widespread adoption is hindered by two key challenges: prolonged scan times and reduced image…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Daniel Tweneboah Anyimadu , Mohammed Abdalla , Mohammed M. Abdelsamea , Ahmed Karam Eldaly

Given an experimental set-up and a fixed number of measurements, how should one take data in order to optimally reconstruct the state of a quantum system? The problem of optimal experiment design (OED) for quantum state tomography was first…

Quantum Physics · Physics 2011-11-22 J. Nunn , B. J. Smith , G. Puentes , J. S. Lundeen , I. A. Walmsley

4D Flow MRI is the state of the art technique for measuring blood flow, and it provides valuable information for inverse problems in the cardiovascular system. However, 4D Flow MRI has a very long acquisition time, straining healthcare…

Numerical Analysis · Mathematics 2025-12-09 Miriam Löcke , Pim van Ooij , Cristóbal Bertoglio

Detecting out-of-distribution (OOD) samples for trusted medical image segmentation remains a significant challenge. The critical issue here is the lack of a strict definition of abnormal data, which often results in artificial problem…

Image and Video Processing · Electrical Eng. & Systems 2023-08-16 Anton Vasiliuk , Daria Frolova , Mikhail Belyaev , Boris Shirokikh

We introduce a novel geometric framework for optimal experimental design (OED). Traditional OED approaches, such as those based on mutual information, rely explicitly on probability densities, leading to restrictive invariance properties.…

Machine Learning · Statistics 2025-10-17 Gavin Kerrigan , Christian A. Naesseth , Tom Rainforth

We propose a novel approach for sequential optimal experimental design (sOED) for Bayesian inverse problems involving expensive models with high-dimensional unknown parameters. This work focuses on designs that maximize the expected…

Optimization and Control · Mathematics 2026-05-05 Tiangang Cui , Karina Koval , Roland Herzog , Robert Scheichl

Optimal experimental design (OED) plays an important role in the problem of identifying uncertainty with limited experimental data. In many applications, we seek to minimize the uncertainty of a predicted quantity of interest (QoI) based on…

Optimization and Control · Mathematics 2022-01-06 Keyi Wu , Peng Chen , Omar Ghattas

A key challenge in maximizing the benefits of Magnetic Resonance Imaging (MRI) in clinical settings is to accelerate acquisition times without significantly degrading image quality. This objective requires a balance between under-sampling…

Machine Learning · Computer Science 2025-06-23 Jacopo Iollo , Geoffroy Oudoumanessah , Carole Lartizien , Michel Dojat , Florence Forbes

We consider infinite-dimensional Bayesian linear inverse problems governed by time-dependent partial differential equations (PDEs) and develop a mathematical and computational framework for optimal design of mobile sensor paths in this…

Optimization and Control · Mathematics 2026-01-22 J. Nicholas Neuberger , Alen Alexanderian , Bart van Bloemen Waanders , Ahmed Attia

The explicit constraint force method (ECFM) was recently introduced as a novel formulation of the physics-informed solution reconstruction problem, and was subsequently extended to inverse problems. In both solution reconstruction and…

Numerical Analysis · Mathematics 2026-01-09 Conor Rowan

Accurate estimation of parameters is paramount in developing high-fidelity models for complex dynamical systems. Model-based optimal experiment design (OED) approaches enable systematic design of dynamic experiments to generate input-output…

Systems and Control · Computer Science 2014-11-12 Ali Mesbah , Stefan Streif

The previously established LOUPE (Learning-based Optimization of the Under-sampling Pattern) framework for optimizing the k-space sampling pattern in MRI was extended in three folds: firstly, fully sampled multi-coil k-space data from the…

Image and Video Processing · Electrical Eng. & Systems 2020-07-30 Jinwei Zhang , Hang Zhang , Alan Wang , Qihao Zhang , Mert Sabuncu , Pascal Spincemaille , Thanh D. Nguyen , Yi Wang

Continuous random processes and fields are regularly applied to model temporal or spatial phenomena in many different fields of science, and model fitting is usually done with the help of data obtained by observing the given process at…

Statistics Theory · Mathematics 2017-03-29 Sándor Baran

Accelerated Magnetic Resonance Imaging (MRI) requires careful optimization of k-space sampling patterns to balance acquisition speed and image quality. While recent advances in deep learning have shown promise in optimizing Cartesian…

Tissues and Organs · Quantitative Biology 2025-08-15 Ruru Xu , Ilkay Oksuz

We propose a control-oriented optimal experimental design (cOED) approach for linear PDE-constrained Bayesian inverse problems. In particular, we consider optimal control problems with uncertain parameters that need to be estimated by…

Optimization and Control · Mathematics 2025-09-01 Madhusudan Madhavan , Alen Alexanderian , Arvind K. Saibaba , Bart van Bloemen Waanders , Rebekah D. White

Cardiac MRI is limited by long acquisition times, which can lead to patient discomfort and motion artifacts. We aim to accelerate Cartesian dynamic cardiac MRI by learning efficient, scan-adaptive undersampling patterns that preserve…

Image and Video Processing · Electrical Eng. & Systems 2026-02-24 Siddhant Gautam , Angqi Li , Prachi P. Agarwal , Anil K. Attili , Jeffrey A. Fessler , Nicole Seiberlich , Saiprasad Ravishankar