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Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

Large language models (LLMs) show promise in radiology but their deployment is limited by computational requirements that preclude use in resource-constrained clinical environments. We investigate whether small language models (SLMs) of 3-4…

Computation and Language · Computer Science 2026-05-05 Pankaj Gupta , Kartik Bose

Machine learning methods are increasingly applied to analyze health-related public discourse based on large-scale data, but questions remain regarding their ability to accurately detect different types of health sentiments. Especially,…

Computation and Language · Computer Science 2025-07-08 Soojong Kim , Kwanho Kim , Hye Min Kim

Public leaderboards increasingly suggest that large language models (LLMs) surpass human experts on benchmarks spanning academic knowledge, law, and programming. Yet most benchmarks are fully public, their questions widely mirrored across…

Artificial Intelligence · Computer Science 2026-03-18 Eshwar Reddy M , Sourav Karmakar

Large language models (LLMs) are increasingly evaluated on reasoning tasks, yet their logical abilities remain contested. To address this, we study LLMs' reasoning in a well-defined fragment of logic: syllogistic reasoning. We cast the…

Computation and Language · Computer Science 2026-01-27 Leonardo Bertolazzi , Manuel Vargas Guzmán , Raffaella Bernardi , Maciej Malicki , Jakub Szymanik

Automated sentiment analysis using Large Language Model (LLM)-based models like ChatGPT, Gemini or LLaMA2 is becoming widespread, both in academic research and in industrial applications. However, assessment and validation of their…

Computation and Language · Computer Science 2024-02-06 Alessio Buscemi , Daniele Proverbio

We investigate the presence of cognitive biases in three large language models (LLMs): GPT-4o, Gemma 2, and Llama 3.1. The study uses 1,500 experiments across nine established cognitive biases to evaluate the models' responses and…

Artificial Intelligence · Computer Science 2025-09-11 Payam Saeedi , Mahsa Goodarzi , M Abdullah Canbaz

Conducting usability testing like cognitive walkthrough (CW) can be costly. Recent developments in large language models (LLMs), with visual reasoning and UI navigation capabilities, present opportunities to automate CW. We explored whether…

Human-Computer Interaction · Computer Science 2025-12-04 Ruican Zhong , David W. McDonald , Gary Hsieh

There is increasing interest in the application large language models (LLMs) to the medical field, in part because of their impressive performance on medical exam questions. While promising, exam questions do not reflect the complexity of…

Large Language Models (LLMs) offer significant potential for delivering health information. However, their reliability in low-resource contexts remains uncertain. This study evaluates GPT-4, Gemini Pro, Llama~3, and Mistral-7B on health…

Computation and Language · Computer Science 2026-03-24 Mohammed Rakibul Hasan

Large language models (LLMs) are increasingly being used for complex research tasks such as literature review, idea generation, and scientific paper analysis, yet their ability to truly understand and process the intricate relationships…

Computation and Language · Computer Science 2025-06-11 Shashidhar Reddy Javaji , Yupeng Cao , Haohang Li , Yangyang Yu , Nikhil Muralidhar , Zining Zhu

The burgeoning interest in Multimodal Large Language Models (MLLMs), such as OpenAI's GPT-4V(ision), has significantly impacted both academic and industrial realms. These models enhance Large Language Models (LLMs) with advanced visual…

Computation and Language · Computer Science 2024-01-01 Yuqing Wang , Yun Zhao

Purpose To evaluate the reasoning capabilities of large language models (LLMs) in performing root cause analysis (RCA) of radiation oncology incidents using narrative reports from the Radiation Oncology Incident Learning System (RO-ILS),…

Research to improve Automated Short Answer Grading has recently focused on Large Language Models (LLMs) with prompt engineering and no- or few-shot prompting to achieve best results. This is in contrast to the fine-tuning approach, which…

Machine Learning · Computer Science 2025-08-07 Joel Walsh , Siddarth Mamidanna , Benjamin Nye , Mark Core , Daniel Auerbach

Generative AI (GenAI) models, particularly large language models (LLMs), have transformed multiple domains, including natural language processing, software analysis, and code understanding. Their ability to analyze and generate code has…

Software Engineering · Computer Science 2025-11-18 Mohammad Meymani , Hamed Jelodar , Parisa Hamedi , Roozbeh Razavi-Far , Ali A. Ghorbani

This study investigated the application of Large Language Models (LLMs) for simplifying biomedical texts to enhance health literacy. Using a public dataset, which included plain language adaptations of biomedical abstracts, we developed and…

Computation and Language · Computer Science 2025-12-19 Primoz Kocbek , Leon Kopitar , Gregor Stiglic

The recent advancements of Small Language Models (SLMs) have opened new possibilities for efficient code generation. SLMs offer lightweight and cost-effective alternatives to Large Language Models (LLMs), making them attractive for use in…

Software Engineering · Computer Science 2026-01-21 Md Mahade Hasan , Muhammad Waseem , Kai-Kristian Kemell , Jussi Rasku , Juha Ala-Rantala , Pekka Abrahamsson

Generative AI increasingly supports educational design tasks, e.g., through Large Language Models (LLMs), demonstrating the capability to design assessment questions that are aligned with pedagogical frameworks (e.g., Bloom's taxonomy).…

Artificial Intelligence · Computer Science 2026-05-15 Chris Davis Jaldi , Anmol Saini , Shan Zhang , Noah Schroeder , Cogan Shimizu , Eleni Ilkou

Large Language Models (LLMs) and AI assistants driven by these models are experiencing exponential growth in usage among both expert and amateur users. In this work, we focus on evaluating the reliability of current LLMs as science…

Computation and Language · Computer Science 2024-09-24 Prasoon Bajpai , Niladri Chatterjee , Subhabrata Dutta , Tanmoy Chakraborty

The learnware paradigm offers a novel approach to machine learning by enabling users to reuse a set of well-trained models for tasks beyond the models' original purposes. It eliminates the need to build models from scratch, instead relying…

Machine Learning · Computer Science 2025-05-20 Zhi-Hao Tan , Zi-Chen Zhao , Hao-Yu Shi , Xin-Yu Zhang , Peng Tan , Yang Yu , Zhi-Hua Zhou